Breast angiosarcoma one year after adenosquamous endometrial cancer - diagnostic pitfalls

• Authors: Darko Zdravkovic , Miroslav Granic , Marija Zdravkovic , Tomislav Randjelović , Dragoljub Bilanović , Biljana Sredić , Svetlana Oprić , Nebojsa Ivanović , Dejan Nikolić , Srdjan Dikić , Borislav Toskovic
• Languages of publication: EN

Abstracts

EN

Angiosarcoma of the breast is a rare and very aggressive tumors originated from endothelial cells lining blood vessels. We report a case of a 55-year-old postmenopausal female with a primary breast angiosarcoma diagnosed just a one year after radical hysterectomy and radiation therapy due to endometrial cancer. The patient initially presented with postmenopausal bleeding. Cytology and biopsy of the endometrium were performed and endometrial adenosquamous carcinoma was diagnosed followed by radical hysterectomy and postoperative local radiatiotherapy (50 Gy). One year later patient presented with a great painful tumorous mass in the right breast. Physical examination revealed an oval tumor, located in upper and outer quadrant of the right breast, around 15 cm in diameter. Mammography and ultrasonography were performed. The angiosarcoma of the breast was confirmed by biopsy. The patient underwent radical mastectomy. Histopathology proved the diagnosis of angiosarcoma (high-grade, numerous mitoses over 10/10 HPF, necrosis, “blood lakes”, infiltrative borders). Differential diagnosis of a breast angiosarcoma should be considered in all painful breast tumours no mather the time and the location of the previous radiation treatment even if benign characteristics of these masses have been detected by mammography and breast ultrasound.

Keywords

EN

Primary breast tumors; Angiosarcoma; Concomitant malignancies; Radical mastectomy

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2013
• Volume: 8
• Issue: 1
• Pages: 52-55

Dates

published

1 - 2 - 2013

online

8 - 12 - 2012

Contributors

author

Darko Zdravkovic

author

Miroslav Granic

author

Marija Zdravkovic

author

Tomislav Randjelović

author

Dragoljub Bilanović

author

Biljana Sredić

• Department of Surgery, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia

author

Svetlana Oprić

• Department of Pathology, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia

author

Nebojsa Ivanović

author

Dejan Nikolić

author

Srdjan Dikić

author

Borislav Toskovic

• Department of Surgery, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia

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Identifiers

DOI

10.2478/s11536-012-0088-7