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2013 | 8 | 1 | 52-55
Article title

Breast angiosarcoma one year after adenosquamous endometrial cancer - diagnostic pitfalls

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EN
Abstracts
EN
Angiosarcoma of the breast is a rare and very aggressive tumors originated from endothelial cells lining blood vessels. We report a case of a 55-year-old postmenopausal female with a primary breast angiosarcoma diagnosed just a one year after radical hysterectomy and radiation therapy due to endometrial cancer. The patient initially presented with postmenopausal bleeding. Cytology and biopsy of the endometrium were performed and endometrial adenosquamous carcinoma was diagnosed followed by radical hysterectomy and postoperative local radiatiotherapy (50 Gy). One year later patient presented with a great painful tumorous mass in the right breast. Physical examination revealed an oval tumor, located in upper and outer quadrant of the right breast, around 15 cm in diameter. Mammography and ultrasonography were performed. The angiosarcoma of the breast was confirmed by biopsy. The patient underwent radical mastectomy. Histopathology proved the diagnosis of angiosarcoma (high-grade, numerous mitoses over 10/10 HPF, necrosis, “blood lakes”, infiltrative borders). Differential diagnosis of a breast angiosarcoma should be considered in all painful breast tumours no mather the time and the location of the previous radiation treatment even if benign characteristics of these masses have been detected by mammography and breast ultrasound.
Publisher

Journal
Year
Volume
8
Issue
1
Pages
52-55
Physical description
Dates
published
1 - 2 - 2013
online
8 - 12 - 2012
Contributors
  • Department of Surgery, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia
  • Department of Pathology, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia
author
  • Department of Surgery, University Medical Centre „Bezanijska kosa“, 11000, Belgrade, Serbia
References
  • [1] de Bree E., van Coevorden F., Peterse J.L., Russell N.S., Rutgers E.J. Bilateral angiosarcoma of the breast after conservative treatment of bilateral invasive carcinoma: genetic predisposition? Eur J Surg Oncol. 2002; 28(4):392–395 http://dx.doi.org/10.1053/ejso.2001.1249[Crossref]
  • [2] Donnell R.M., Rosen P.P., Lieberman P.H., Kaufman R.J., Kay S., Braun D.W. Jr, et al. Agiosarcoma and other vascular tumors of breast. Am J Surg Pathol 1981; 5:629–642 http://dx.doi.org/10.1097/00000478-198110000-00005[Crossref]
  • [3] Biswas T., Tang P., Muhs A., Ling M. Angiosarcoma of the breast: a rare clinicopathological entity. Am J Clin Oncol. 2009;32(6):582–586 http://dx.doi.org/10.1097/COC.0b013e3181967f09[Crossref]
  • [4] Shabahang M., Franceschi D., Sundaram M., Castillo M.H., Moffat F.L., Frank D.S., et al. Surgical management of primary breast sarcoma. Am Surg. 2002; 68(8):673–677
  • [5] Monroe A.T., Feigenberg S.J., Mendenhall N.P. Angiosarcoma after breast conserving therapy. Cancer. 2003; 97:1832–1840 http://dx.doi.org/10.1002/cncr.11277[Crossref]
  • [6] Styring E., Fernebro J., Jönsson P.E., Ehinger A., Engellau J., Rissler P., et al. Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall. Breast Cancer Res Treat. 122(3):883–887 [WoS]
  • [7] Cortesi L., De Matteis E., Rashid I., Cirilli C., Proietto M., Rivasi F. et al. Distribution of second primary malignancies suggests a bidirectional effectbetween breast and endometrial cancer: a population-based study. Int J Gynecol Cancer.; 19(8):1358–1363 [WoS]
  • [8] Schmidt G.B. Ueber das Angiosarkom der Mamma, Arch Klin Chir 1887; 36:421–427
  • [9] Tahir M., Hendry P., Baird L., Qureshi N.A., Ritchie D., Whitford P. Radiation induced angiosarcoma as a sequel of radiotherapy for breast cancer following conservative surgery. Int J Surg Oncol 2006;3:1–4 http://dx.doi.org/10.1186/1477-7800-3-1[Crossref]
  • [10] Rao J., Dekoven J.G., Beatty J.D., Jones G. Cutaneous angiosarcoma as a delayed Complication of radiation therapy for carcinoma of the breast. J Am Acad Dermatol 2003;49:532–538 http://dx.doi.org/10.1067/S0190-9622(03)00428-6[Crossref]
  • [11] Roy P., Clark M.A., Thomas J.M. Stewart-Treves syndrome - treatment and outcome in six patients from a single centre. Eur J Surg Oncol. 2004;30(9): 982–986 [Crossref]
  • [12] Amalinei C., Balan C, Ivan L., Socolov R, Socolov D., Cotutiu C. Multiple primary malignant neoplasms-case report. CEJMed. 2006; 1(1): 87–98
  • [13] Cozen W., Bernstein L., Wang F., Press M.F., Mack T.M. The risk of angiosarcoma following primary breast cancer. Br J Cancer 1999;81:532–536 http://dx.doi.org/10.1038/sj.bjc.6690726[Crossref]
  • [14] Huang J., Mackillop W.J. Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 2001; 92(1):172–180 http://dx.doi.org/10.1002/1097-0142(20010701)92:1<172::AID-CNCR1306>3.0.CO;2-K[Crossref]
  • [15] Cahan W.G., Woodard H.Q. Sarcoma arising in irradiated bone; report of 11 cases. Cancer 1948; 1(1):3–9 http://dx.doi.org/10.1002/1097-0142(194805)1:1<3::AID-CNCR2820010103>3.0.CO;2-7[Crossref]
  • [16] Seinen J.M., Styring E., Verstappen V., Vult von Steyern F., Rydholm A., Suurmeijer A.J., et al. Radiation-Associated Angiosarcoma After Breast Cancer: High Recurrence Rate and Poor Survival Despite Surgical Treatment with R0 Resection. Ann Surg Oncol. 2012 Mar 31. [Epub ahead of print]
  • [17] West J., Liao S.Y., Cho D. Angiosarcoma after breast conservation: diagnostic pitfalls. Clin Breast Cancer. 2008;8(1):94–96 http://dx.doi.org/10.3816/CBC.2008.n.009[WoS][Crossref]
  • [18] Lamblin G., Oteifa M., Zinzindohoue C., Isaac S., Termine L., Bobin J.Y. Angiosarcoma after conservative treatment and radiation therapy for adenocarcinoma of the breast. Eur J Surg Oncol 2001; 27(2):146–151 http://dx.doi.org/10.1053/ejso.2000.1073[Crossref]
  • [19] Kikawa Y., Konishi Y., Nakamoto Y., Harada T., Takeo M., Ogata M., et al. Angiosarcoma of the breast:s pecificfindings of MRI. Breast Cancer 2006; 13(4):369–373 http://dx.doi.org/10.2325/jbcs.13.369[Crossref]
  • [20] Rohan V.S., Hanji A.M., Patel J.J., Tankshali R.A. Primary angiosarcoma of the breast in a postmenopausal patient. J Cancer Res Ther 2010; 6(1): 120–122 http://dx.doi.org/10.4103/0973-1482.63543[Crossref]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-012-0088-7
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