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2013 | 8 | 1 | 30-40

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The role of selected risk factors for development of oesophageal cancer


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A hospital-based analytical observational case-control study of 88 oesophageal cancer cases and 200 controls was conducted in the University Hospital Olomouc. A standardized questionnaire was used. The adjusted odds ratio (OR) are calculated by logistic regression. The adjusted odds ratios for tobacco smoking were 6.20 (95% CI 2.78–13.83), 10.64 (95% CI 3.46–32.72) and 3.53 (95% CI 1.26–9.88) for oesophageal cancer, for oesophageal squamous cell carcinoma, and oesophageal adenocarcinoma, respectively. An inverse association with overweight and obesity was found in both histological types. In adenocarcinoma, there was a relatively strong positive association with a statistically significant result for alcohol consumption only in a group consuming more than 300 g of alcohol weekly; the OR was 5.81 (95% CI 1.17–28.84). The strong, statistically significant association was found in alcohol consumption regardless of histological type: the OR was 4.41 (95% CI 1.09–17.84). In a group with 20 or more X-ray exposures, there was a very strong statistically significant positive association. In vegetable consumption, an inverse association was found that was statistically significant only if more than 8 portions of vegetables were eaten weekly, ORs were 0.02–0.11.










Physical description


1 - 2 - 2013
8 - 12 - 2012


  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic
  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic
  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic
  • Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic
  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic
  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic
  • Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic
  • Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic


  • [1] Dušek L, et al. Epidemiology of malignant tumours of the oesophagus (C15). In: Czech cancer care in numbers 2008–2009. Praha: Grada; 2010
  • [2] Dušek L, Mužík J, Kubásek M, Koptíková J, Žaloudík J, Vytula R. Epidemiologie zhoubných nádorů v České republice [online]. Masarykova Univerzita 2005 [cited 2012-6-21]. Available from www:http://www.svod.cz. Version 7.0
  • [3] Klener P. Karcinom jícnu. In: Klener P. Klinická onkologie. Praha: Karolinum-Galén; 2002. p. 397–398
  • [4] Bray I, Brennan P, Boffetta P. Projections of alcohol- and tobacco-related cancer mortality in Central Europe. Int J Cancer. 2000; 87: 122–128 http://dx.doi.org/10.1002/1097-0215(20000701)87:1<122::AID-IJC18>3.0.CO;2-W[Crossref]
  • [5] Abnet CC, Freedman ND, Hollenbeck AR, Fraumeni JF Jr, Leitzmann M, Schatzkin A. A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur J Cancer. 2008; 44: 465–471 http://dx.doi.org/10.1016/j.ejca.2007.12.009[Crossref]
  • [6] Veugelers PJ, Porter GA, Guernsey DL, Casson AG. Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma. Dis Esophagus. 2006; 19: 321–328 http://dx.doi.org/10.1111/j.1442-2050.2006.00602.x[Crossref]
  • [7] Solaymani-Dodaran M, Logan R, West J. Risk of oesophageal cancer in Barrett’s oesophagus and gastrooesophageal reflex. Gut. 2004; 53: 1070–1074 http://dx.doi.org/10.1136/gut.2003.028076[Crossref]
  • [8] Crane SJ, Locke GR 3rd, Harmsen WS, Diehl NN, Zinsmeister AR, Melton LJ 3rd. Subsite-specific risk factors for esophageal and gastric adenocarcinoma. Am J Gastroeneterol. 2007; 102: 1596–1602 http://dx.doi.org/10.1111/j.1572-0241.2007.01234.x[Crossref]
  • [9] Kubo A, Corley DA. Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006; 15: 872–878 http://dx.doi.org/10.1158/1055-9965.EPI-05-0860[Crossref]
  • [10] Winberg H, Lindblad M, Lagergren J, Dahlstrand H. Risk factors and chemoprevention in Barrett’s esophagus-an update. Scand J Gastroenterol. 2012; 47(4): 397–406 http://dx.doi.org/10.3109/00365521.2012.667145[Crossref]
  • [11] van Blankenstein M, Looman CW, Hop WC, Bytzer P. The incidence of adenocarcinoma and squamous cell carcinoma of the esophagus: Barrett’s esophagus makes a difference. Am J Gastroenterol. 2005; 100: 766–774 http://dx.doi.org/10.1111/j.1572-0241.2005.40790.x[Crossref]
  • [12] Bosetti C, Rosato V, Polesel J, Levi F, Talamini R, Montella M. Diabetes mellitus and cancer risk in a network of case-control studies. Nutr Cancer. 2012 Apr 20: 1–9
  • [13] Lambert R, Hainaut P. Epidemiology of oesophagogastric cancer. Baillieres Best Pract Res Clin Gastroenterol. 2007; 21(6): 921–945 http://dx.doi.org/10.1016/j.bpg.2007.10.001[Crossref]
  • [14] Vioque J, Barber X, Bolumar F, Porta M, Santibáñez M, de la Hera MG et al. PANESOES Study Group. Esophageal cancer risk by type of alcohol drinking and smoking: a case-control study in Spain. BMC Cancer. 2008; 8: 221 http://dx.doi.org/10.1186/1471-2407-8-221[Crossref]
  • [15] Lin J, Zeng R, Cao W, Luo R, Chen J, Lin Y. Hot beverage and food intake and esophageal cancerin southern China. Asian Pac J Cancer Prev. 2011; 12(9): 2189–2192
  • [16] Guo F, Liu Y, Wang X, He Z, Weiss NS, Madeleine MM. Human papillomavirus infection and esophageal squamous cell carcinoma: a casecontrol study. Cancer Epidemiol Biomarkers Prev. 2012; 21(5): 780–785 http://dx.doi.org/10.1158/1055-9965.EPI-11-1206[Crossref]
  • [17] Mao WM, Zheng WH, Ling ZQ. Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev. 2011; 12(10): 2461–2466
  • [18] Freedman ND. Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A. Prospective investigation of the cigarette smoking-head and neck cancer association by sex. Cancer. 2007; 110: 1593–1601 http://dx.doi.org/10.1002/cncr.22957[Crossref]
  • [19] Liao LM, Vaughan TL, Corley DA, Cook MB, Casson AG, Kamangar F. Nonsteroidal anti-inflammatory drug use reduces the risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis. Gastroenterology. 2012; 142(3): 442–452 http://dx.doi.org/10.1053/j.gastro.2011.11.019[Crossref]
  • [20] Jurisi V, Stojacic-Djenic S, Colovic N, Konjevic G. The role of cytokine in regulation of the natural killer cell aktivity. Srp Arh Celok Lek. 2008; 136(7–8): 423–429 http://dx.doi.org/10.2298/SARH0808423J[Crossref]
  • [21] Bogdanov M, Perisic M, Jurisic V, Stojacic-Djenic S, Kerkez MM. Ultrasonographic examination of the liver circulation in patients with liver metastasis from colorectal cancer. J BUON. 2010; 15(2): 378–381
  • [22] Yang H, Sukocheva OA, Hussey DJ, Watson DI. Estrogen, male dominance and esophageal adenocarcinoma: is there a link? World J Gastroenterol. 2012; 18(5): 393–400 http://dx.doi.org/10.3748/wjg.v18.i5.393[Crossref]
  • [23] Balbuena L, Casson AG. Physical activity, obesity and risk for esophageal adenocarcinoma. Future Oncol. 2009; 5: 1051–1063 http://dx.doi.org/10.2217/fon.09.65[Crossref]
  • [24] Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA, Travis RC. Diet, nutrition and the prevention of cancer], Public Health Nutr. 2004; 7: 187–200 http://dx.doi.org/10.1079/PHN2003588[Crossref]
  • [25] United nations scientific committee on the effects of atomic radiation unscear 2008 (Unscear 2008). Sources of ionizing radiation: report to the general assembly, with scientific annexes, report vol. I. Vienna: 2010
  • [26] Lee CI, Elmore JG. Radiation-related risks of imaging studies. [cited 2012 Jan 2] Available from: http://www.uptodate.com/contents/radiationrelated-risks-of-imaging-studies?source=search_result&selectedTitle=6~150
  • [27] Patel ZS, Grugan KD, Rustgi AK, Cucinotta FA, Huff JL. Ionizing radiation enhances esophageal epithelial cell migration and invasion through a paracrine mechanism involving stromal-derived hepatocyte growth factor. Radiat Res. 2012; 177(2): 200–208 http://dx.doi.org/10.1667/RR2790.1[Crossref]
  • [28] Terry P, Lagergren J, Hansen H, Wolk A, Nyrén O. Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. Eur J Cancer Prev. 2001; 10: 365–369 http://dx.doi.org/10.1097/00008469-200108000-00010[Crossref]
  • [29] Brown LM, Hoover R, Silverman D, Baris D, Hayes R, Swanson GM. et al. Excess incidence of squamous cell esophageal cancer among US Black men: role of social class and other risk factors. Am J Epidemiol. 2001; 153: 114–122 http://dx.doi.org/10.1093/aje/153.2.114[Crossref]
  • [30] Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst. 2003; 95: 1404–1413 http://dx.doi.org/10.1093/jnci/djg047[Crossref]
  • [31] Steevens J, Schouten LJ, Goldbohm RA, van den Brandt PA. Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. Int J Cancer. 2011; 129: 2681–2693 http://dx.doi.org/10.1002/ijc.25928[Crossref]
  • [32] Bravi F, Edefonti V, Randi G, Garavello W, La Vecchia C, Ferraroni M et al. Dietary patterns and the risk of esophageal cancer. Ann Onc. 2012; 23(3): 765–770 http://dx.doi.org/10.1093/annonc/mdr295[Crossref]
  • [33] Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127: 2893–29
  • [34] Coleman MP, Gatta G, Verdecchia A, Estève J, Sant M, Storm H et al. EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century. Ann Oncol. 2003; 14: 128–149 http://dx.doi.org/10.1093/annonc/mdg756[Crossref]
  • [35] Hashibe M, Boffetta P, Janout V, Zaridze D, Shangina O, Mates D et al. Esophageal cancer in Central and Eastern Europe: tobacco and alcohol. Int J Cancer. 2007; 120: 1518–1522 http://dx.doi.org/10.1002/ijc.22507[Crossref]
  • [36] Lee CH, Lee JM, Wu DC, Hsu HK, Kao EL, Huang HL et al. Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan. Int J Cancer. 2005; 113: 475–482 http://dx.doi.org/10.1002/ijc.20619[Crossref]
  • [37] Jankowski JA, Wright NA, Meltzer SJ, Triadafilopoulos G, Geboes K, Casson AG et al. Molecular evolution of the metaplasia-dysplasiaadenocarcinoma sequence in the esophagus. Am J Pathol. 1999; 154: 965–973 http://dx.doi.org/10.1016/S0002-9440(10)65346-1[Crossref]
  • [38] Wu AH, Wan P, Bernstein L. A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States). Cancer Causes Control. 2001; 12: 721–732 http://dx.doi.org/10.1023/A:1011290704728[Crossref]
  • [39] Chen Z, Yang G, Zhou M, Smith M, Offer A, Ma J et al. Body mass index and mortality from ischaemic heart disease in a lean population: 10 year prospective study of 220,000 adult men. Int J Epidemiol. 2006; 35: 141–150 http://dx.doi.org/10.1093/ije/dyi215[Crossref]
  • [40] Gammon MD, Schoenberg JB, Ahsan H, Risch HA, Vaughan TL, Chow WH et al. Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst. 1997; 89: 1277–1284 http://dx.doi.org/10.1093/jnci/89.17.1277[Crossref]
  • [41] Lindblad M, Rodríguez LA, Lagergren J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric noncardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control. 2005; 16: 285–294 http://dx.doi.org/10.1007/s10552-004-3485-7[Crossref]
  • [42] Vial M, Grande L, Pera M. Epidemiology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third. Recent Results Cancer Res. 2010; 182: 1–17 http://dx.doi.org/10.1007/978-3-540-70579-6_1[Crossref]
  • [43] Ouattara M, D’Journo XB, Loundou A, Trousse D, Dahan L, Doddoli C. Body mass index kinetics and risk factors of malnutrition one year after radical oesophagectomy for cancer. Eur J Cardiothorac Surg. 2012; 41(5): 1088–1093 http://dx.doi.org/10.1093/ejcts/ezr182[Crossref]
  • [44] Hampel H, Abraham NS, El-Serag HB. Metaanalysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med. 2005; 143: 199–211 [Crossref]
  • [45] Sovová E, Hobzová M, Pastucha D. et al. Syndrom obstrukční spánkové apnoe a kardiovaskulární komplikace - úloha mezioborové spolupráce. Cesk Slov Neurol. 2010; 73/106(1): 68–72
  • [46] Pastucha D, Sovová E, Mailinčíková J et al. Pohybové aktivity jako součást prevence kardiovaskulárních onemocnění v ordinaci praktického lékaře. Praktický lékař. 2010; 90(8): 467–470
  • [47] IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. IARC Alcoholic Beverage Consumption and Ethyl Carbamate (Urethane). IARC Monogr Eval Carcinog Risks Hum. 2007: 96
  • [48] Wu AH, Wan P, Bernstein L. A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States). Cancer Causes Control. 2001; 12: 721–732 http://dx.doi.org/10.1023/A:1011290704728[Crossref]
  • [49] Kollarova H, Machova L, Horakova D, Janoutova G, Cizek L, Janout V. Risk factors of oesophageal cancer. Gastrology and Hepatology. 2008; 62: 79–83
  • [50] Micke O, Schafer U, Glashorster M, Prott FJ, Willich N. Radiation-induced esophageal carcinoma 30 years after mediastinal irradiation: case report and review of the literature. Jpn J Clin Oncol. 1999; 29: 164–170 http://dx.doi.org/10.1093/jjco/29.3.164[Crossref]
  • [51] Marchese MJ, Liskow A, Chang CH. Radiation therapy associated cancer of the esophagus. N Y State J Med. 1986; 86: 152–153
  • [52] Santibañez M, Vioque J, Alguacil J, Barber X, García de la Hera M, Kauppinen T, PANESOES Study Group. Occupational exposures and risk of oesophageal cancer by histological type: a case-control study in eastern Spain. Occup Environ Med. 2008; 65: 774–781 http://dx.doi.org/10.1136/oem.2007.037929[Crossref]
  • [53] He Z, Zhao Y, Guo C, Liu Y, Sun M, Liu F et al. Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey. Br J Cancer. 2010; 103(7): 1085–1088 http://dx.doi.org/10.1038/sj.bjc.6605843[Crossref]
  • [54] Gonzalez CA, Pera G, Agudo A, Bueno-de-Mesquita HB, Ceroti M, Boeing H et al. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPICEURGAST). Int J Cancer. 2006; 118: 2559–2566 http://dx.doi.org/10.1002/ijc.21678[Crossref]
  • [55] Glade MJ. Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, 1997. Nutrition. 1999; 15: 523–526 http://dx.doi.org/10.1016/S0899-9007(99)00021-0[Crossref]
  • [56] Nutritional aspects of the development of cancer. Report of the Working Group on Diet and Cancer of the Committee on Medical Aspects of Food and Nutrition Policy. Rep Health Soc Subj. (Lond) 1998; 48:i–xiv: 1–274
  • [57] Hajizadeh B, Jessri M, Moasheri SM, Rad AH, Rashidkhani B. Fruits and vegetables consumption and esophageal squamous cell carcinoma: a casecontrol study. Nutr Cancer. 2011; 63: 707–713 http://dx.doi.org/10.1080/01635581.2011.563028[Crossref]
  • [58] Anderson LA, Watson RG, Murphy SJ, Johnston BT, Comber H, McGuigan J et al. Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. World J Gastroenterol. 2007; 13: 1585–1594 [Crossref]

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