The role of selected risk factors for development of oesophageal cancer

• Authors: Helena Kollárová , Kateřina Azeem , Silvie Magnusková , Hana Tomášková , Jarmila Ševčíková , Dagmar Horáková , Vojtěch Kamarád , Vladimír Janout
• Languages of publication: EN

Abstracts

EN

A hospital-based analytical observational case-control study of 88 oesophageal cancer cases and 200 controls was conducted in the University Hospital Olomouc. A standardized questionnaire was used. The adjusted odds ratio (OR) are calculated by logistic regression. The adjusted odds ratios for tobacco smoking were 6.20 (95% CI 2.78–13.83), 10.64 (95% CI 3.46–32.72) and 3.53 (95% CI 1.26–9.88) for oesophageal cancer, for oesophageal squamous cell carcinoma, and oesophageal adenocarcinoma, respectively. An inverse association with overweight and obesity was found in both histological types. In adenocarcinoma, there was a relatively strong positive association with a statistically significant result for alcohol consumption only in a group consuming more than 300 g of alcohol weekly; the OR was 5.81 (95% CI 1.17–28.84). The strong, statistically significant association was found in alcohol consumption regardless of histological type: the OR was 4.41 (95% CI 1.09–17.84). In a group with 20 or more X-ray exposures, there was a very strong statistically significant positive association. In vegetable consumption, an inverse association was found that was statistically significant only if more than 8 portions of vegetables were eaten weekly, ORs were 0.02–0.11.

Keywords

EN

Oesophageal adenocarcinoma; Oesophageal squamous cell carcinoma; Risk factor; Protective factor; Case-control study; Analysis

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2013
• Volume: 8
• Issue: 1
• Pages: 30-40

Dates

published

1 - 2 - 2013

online

8 - 12 - 2012

Contributors

author

Helena Kollárová

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Kateřina Azeem

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Silvie Magnusková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Hana Tomášková

• Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic

author

Jarmila Ševčíková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Dagmar Horáková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Vojtěch Kamarád

• Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic

author

Vladimír Janout

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

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Identifiers

DOI

10.2478/s11536-012-0054-4