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2012 | 7 | 5 | 596-598

Article title

Endoscopic classifications of esophageal changes in chagasic megaesophagus


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The objective of this report is to propose a classification of endoscopic changes for chagasic megaesophagus based on macroscopic findings. Thirty patients with advanced megaesophagus surgically treated using the Doria Serra technique (1968)3 were enrolled in this quasi-randomized study. All participants were treated in the Surgical Department of Hospital de Base of the Medicine School in São José do Rio Preto (FAMERP), Brazil from January 1995 to December 1999. The ages of the 17 male (56.6%) and 13 female (43.3%) patients ranged from 38 to 71 years. All participants were submitted to esophagogastroduodenal endoscopy with the following classification being proposed: mild, moderate and severe esophagitis. The current study demonstrates a correlation between the classifications of endoscopic changes and the degree of histological alterations of the esophageal mucosa in chagasic megaesophagus. Thus, this is a novel option for endoscopic evaluation of patients with this disease.










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1 - 10 - 2012
28 - 7 - 2012


  • Department of Surgery in Medicine School of São José do Rio Preto -FAMERP, São José do Rio Preto, Brazil
  • Medicine School of Jundiai, Jundiai, Brazil
  • Department of Cardiology and Cardiovascular Surgery in Medicine School in São José do Rio Preto (FAMERP), and CNPq (National Council for Research and Development), São José do Rio Preto, Brazil


  • [1] Oliveira GC, Lopes LR, Andreollo NA, Coelho Neto J de S. Surgically treated megaesophagus: epidemiological profile of patients operated in the Clinical Hospital of the State University of Campinas between 1989 and 2005]. Rev Soc Bras Med Trop. 2008 Mar–Apr;41(2):183–188 http://dx.doi.org/10.1590/S0037-86822008000200010[WoS][Crossref]
  • [2] Nascimento RD, de Souza Lisboa A, Fujiwara RT, de Freitas MA, Adad SJ, Oliveira RC, d’Avila Reis D, da Silveira AB. Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus. Hum Pathol. 2010 Apr;41(4):528–34. Epub 2009 Dec 11 http://dx.doi.org/10.1016/j.humpath.2009.05.018[WoS][Crossref]
  • [3] Lewandowski A. Diagnostic criteria and surgical procedure for megaesophagus-a personal experience. Dis Esophagus. 2009;22(4):305–9. Epub 2008 Dec 22 http://dx.doi.org/10.1111/j.1442-2050.2008.00897.x[WoS][Crossref]
  • [4] Eckardt VF, Hoischen T, Bernhard G. Life expectancy, complications, and causes of death in patients with achalasia: results of a 33-year follow-up investigation. Eur J Gastroenterol Hepatol. 2008 Oct;20(10):956–960 http://dx.doi.org/10.1097/MEG.0b013e3282fbf5e5[WoS][Crossref]
  • [5] Morita S, Herani BF, Coleoni RN, Borin AA, Santos JS, Brienze LS, Carvalho FL. Endoscopic and histologic evaluation of advanced megaesophagus after esophagocardioplasty, vagotomy-antrectomy and roux-en-Y gastrojejunostomy (Serra Dória operation) Dis Esophagus 2005;18(6):365–369 http://dx.doi.org/10.1111/j.1442-2050.2005.00517.x[Crossref]
  • [6] Borin AA, Campos Jr E. Resultados da cirurgia de Serra-Dória para megaesôfago chagásico avançado e após recidiva de cardiomiotomia. ABCD Arq Bras Cir Dig 2002;(Supl):11

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