Ventricular septal defects in function of maternal sociodemographic aspects

• Authors: Attila Vereczkey , Zsolt Kósa , Melinda Csáky-Szunyogh , Róbert Urbán , Andrew Czeizel
• Languages of publication: EN

Abstracts

EN

The objective of our project is to reveal the possible etiological factors of different congenital cardiovascular abnormalities. In this study, we evaluated single ventricular septal defect (VSD) after surgical correction or with lethal outcome. The birth outcomes of these cases in the function of maternal socio-demographic features were evaluated. Data are based on 1,659 VSD cases, 2,534 matched controls and 38,151 all controls without any defects, in addition in the mothers of 19,393 malformed controls with other isolated defects in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. VSD had mild female excess with a higher rate of preterm birth and mainly low birth weight indicating intrauterine growth restriction of affected fetuses, particularly in males and full-term or average weighted cases. The mothers of cases with VSD had lower socioeconomic status and higher rate of smoking and particularly drinking habit. The evaluation of medically recorded pregnancy complications showed an association of gestational diabetes with a higher risk of VSD. In conclusion, the association of small localized size of VDS and obvious fetal growth restriction needs further explanation in these cases, while gestational diabetes, lower socioeconomic status and adverse lifestyle of pregnant women may have a role in the origin of VSD.

Keywords

EN

Ventricular septal defect; Birth outcomes; Intrauterine growth restriction; Lower socioeconomic status; Alcohol drinking; Smoking; Gestational diabetes; Case-control population-based study

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2012
• Volume: 7
• Issue: 4
• Pages: 511-522

Dates

published

1 - 8 - 2012

online

24 - 5 - 2012

Contributors

author

Attila Vereczkey

• Versys Clinics, Human Reproduction Institute, Madarász Viktor utca 47-49, 1138, Budapest, Hungary

author

Zsolt Kósa

• Versys Clinics, Human Reproduction Institute, Madarász Viktor utca 47-49, 1138, Budapest, Hungary

author

Melinda Csáky-Szunyogh

• National Centre for Healthcare Audit and Inspection, Váci út 174, 1138, Budapest, Hungary

author

Róbert Urbán

• Department of Personality and Health Psychology, Eötvös Loránd University, Egyetem tér 1-3, Budapest, Hungary

author

Andrew Czeizel

• Foundation for the Community Control of Hereditary Diseases, Törökvész lejtő 32, 1026, Budapest, Hungary

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Identifiers

DOI

10.2478/s11536-012-0024-x