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2012 | 7 | 4 | 497-502

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Synovial sarcoma of carotid space


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Synovial sarcomas are malignant tumors of mesenchymal origin, extremely rarely located in the area of the head and neck. Histologically they can be monophasic, biphasic or poorly differentiated with numerous differential diagnostic dilemmas. A 54-year-old male with synovial sarcoma of the carotid space is presented. The patient refused suggested postoperative radiotherapy and, nine months after the primary surgery, local relapse was verified. Following surgical resection of the local relapse, postoperative radiotherapy treatment was utilized. Ten months after the second surgery, secondary deposits in the lungs were radiographically confirmed, and local recurrence was noticed again. Treatment was continued with symptomatic therapy and eleven months later patient died. Synovial sarcomas of the carotid space are extremely rare, with complex surgical approaches and pathohistological differential diagnostic dilemmas. Diagnosis requires determination of the immunophenotype of the tumor cells, whereas therapy requires an aggressive surgical approach and postoperative radiotherapy.










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1 - 8 - 2012
24 - 5 - 2012


  • Department of Maxillofacial Surgery, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia
  • Department of Pathology, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia
  • Department of Pathology, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia
  • Department of Plastic Surgery, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia
  • Department of Pathology, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia
  • Faculty of Dental Medicine Belgrade, Maxillofacial Surgery Clinic, 8 Dr Subotica Str., 11000, Belgrade, Serbia
  • Department of Oncology, Clinical Center Kragujevac, 30 Zmaj Jovina Str., 34000, Kragujevac, Serbia


  • [1] Kusuma S., Skarupa D.J., Ely K.A., Cmelak A.J., Burkey B.B., Synovial sarcoma of the head and neck: a review of its diagnosis and management and a report of a rare case of orbital involvement, Ear Nose Throat J. 2010, 89, 280–283
  • [2] Hirsch R. J., Yousem D.M., Loevner L.A., Montone K.T., Chalian A.A., Hayden R.E., et al., Synovial sarcomas of the head and neck: MR findings, AJNR Am. J. Neuroradiol., 2001, 22, 851–857
  • [3] Ferrari A., Gronchi A., Casanova M., Meazza C., Gandola L., Collini P., et al., Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution, Cancer, 2004, 101, 627–634 http://dx.doi.org/10.1002/cncr.20386[Crossref]
  • [4] Harb W. J., Luna M.A., Patel S.R., Ballo M.T., Roberts D.B., Sturgis E.M., Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension, Head Neck, 2007, 29, 731–740 http://dx.doi.org/10.1002/hed.20564[Crossref]
  • [5] Suster S., Moran C.A., Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases, Am. J. Surg. Pathol., 2005, 29, 569–578 http://dx.doi.org/10.1097/01.pas.0000157934.50936.3e[Crossref]
  • [6] Enzinger F. M., Weiss S.W., Soft tissue tumors, 4th ed., Mosby, St. Louis, 2001
  • [7] Perez C. A., Thorstad W.L., Unusual nonepithelial tumors of head and neck, In: Halperin C.E., Perez C.A., Brady L.W. (Eds.), Principles and practice of radiation oncology, 5th ed., Lippincott, Williams & Wilkins, Philadelphia, 2008
  • [8] Okcu M. F., Munsell M., Treuner J., Mattke A., Pappo A., Cain A., et al., Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome, J. Clin. Oncol., 2003, 21, 1602–1611 http://dx.doi.org/10.1200/JCO.2003.07.008[Crossref]
  • [9] Amble F. R., Olsen K.D., Nascimento A.G., Foote R.L., Head and neck synovial cell sarcoma, Otolaryngol. Head Neck Surg., 1992, 107, 631–637
  • [10] Coffin C. M., Synovial based tumors and synovial sarcoma, In: Coffin C.M., O’shea P.A., Dehner L.P. (Eds.), Pediatric soft tissue tumors: a clinical, pathological, and therapeutic approach, 1st ed., Williams and Wilkins, Baltimore, 1997
  • [11] Rangheard A. S., Vanel D., Viala J., Schwaab G., Casiraghi O., Sigal R., Synovial Sarcomas of the Head and Neck: CT and MR Imaging Findings of Eight Patients, AJNR Am. J. Neuroradiol., 2001, 22, 851–857
  • [12] Cihak R. A., Lydiatt W.M., Lydiatt D.D., Bridge J.A., Synovial sarcoma of the head and neck: chromosomal translocation (X; 18) as a diagnostic aid, Head Neck, 1997, 19, 549–553 http://dx.doi.org/10.1002/(SICI)1097-0347(199709)19:6<549::AID-HED14>3.0.CO;2-0[Crossref]
  • [13] Hanna E., Wanamaker J., Adelstein D., Tubbs R., Lavertu P., Extranodal lymphomas of the head and neck: a 20-year experience. Arch. Otolaryngol. Head Neck Surg., 1997, 123, 1318–1323 http://dx.doi.org/10.1001/archotol.1997.01900120068011[Crossref]
  • [14] Ouansafi I., Klein M., Sugrue C., Morgenstern N., Frank D., Wasserman P., Monophasic parapharyngeal synovial sarcoma diagnosed by cytology, immunocytochemistry, and molecular pathology: case report and review of the literature, Diagn Cytopathol, 2010, 38, 822–827 http://dx.doi.org/10.1002/dc.21328[WoS][Crossref]
  • [15] Krane J. F., Bertoni F., Fletcher C.D., Myxoid synovial sarcoma: an underappreciated morphologic subset, Mod Pathol, 1999, 12, 456–462
  • [16] Varela-Duran J., Enzinger F.M., Calcifying synovial sarcoma, Cancer, 1982, 50, 345–352 http://dx.doi.org/10.1002/1097-0142(19820715)50:2<345::AID-CNCR2820500231>3.0.CO;2-Y[Crossref]
  • [17] van de Rijn M., Barr F.G., Xiong Q.B., Hedges M., Shipley J., Fisher C., Poorly differentiated synovial sarcoma: an analysis of clinical, pathologic, and molecular genetic features, Am. J. Surg. Pathol., 1999, 23, 106–112 http://dx.doi.org/10.1097/00000478-199901000-00012[Crossref]
  • [18] Machen S. K., Fisher C., Gautam R.S., Tubbs R.R., Goldblum J.R., Utility of cytokeratin subsets for distinguishing poorly differentiated synovial sarcoma from peripheral primitive neuroectodermal tumour, Histopathology, 1998, 33, 501–507 http://dx.doi.org/10.1046/j.1365-2559.1998.00562.x[Crossref]
  • [19] Olsen S. H., Thomas D.G., Lucas D.R., Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma, Mod Pathol, 2006, 19, 659–668 http://dx.doi.org/10.1038/modpathol.3800569[Crossref]
  • [20] Carrillo R., Rodriguez-Peralto J.L., Batsakis J.G., Synovial sarcomas of the head and neck, Ann. Otol. Rhinol. Laryngol., 1992, 101, 367–370
  • [21] Kartha S. S., Bumpous J.M., Synovial Cell Sarcoma: Diagnosis, Treatment, and Outcomes, Laryngoscope, 2002; 112, 1979–1982 http://dx.doi.org/10.1097/00005537-200211000-00013[Crossref]
  • [22] Bertolini F., Bianchi B., Pizzigallo A., Tullio A., Sesenna E., Synovial cell sarcoma of the neck. Case report and review of the literature, Acta Otorhinolaryngol. Ital., 2003, 23, 391–395
  • [23] Palmerini E., Staals E.L., Alberghini M., Zanella L., Ferrari C., Benassi M.S., Picci P., et al., Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution, Cancer, 2009, 115, 2988–2998 http://dx.doi.org/10.1002/cncr.24370[Crossref]
  • [24] Ramamurthy L., Nassar W.Y., Hasleton P.S., Gattamaneni H.R., Orton C.L., Synovial sarcoma of the pharynx, J. Laryngol. Otol., 1995, 109, 1207–1210
  • [25] Bukachevsky R. P., Pincus R.L., Shechtman F.G., Sarti E., Chodosh P., Synovial sarcoma of the head and neck., Head Neck, 1992, 14, 44–48 http://dx.doi.org/10.1002/hed.2880140110[Crossref]

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