Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2012 | 7 | 2 | 262-268

Article title

Safety and efficacy of exercise testing with atropine in patients with recent uncomplicated ST elevation acute myocardial infarction


Title variants

Languages of publication













Physical description


1 - 4 - 2012
3 - 2 - 2012


  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy
  • Division of Cardiology “P. Borsellino” G.F. Ingrassia Hospital, Palermo, Italy
  • Districtual Cardiology ASL 6, Palermo, Italy
  • Districtual Cardiology ASL 6, Palermo, Italy
  • Department of Internal Medicine, University of Palermo, Palermo, Italy
  • Division of Cardiology “P. Borsellino” G.F. Ingrassia Hospital, Palermo, Italy


  • [1] Gibbons RJ, Balady GJ, Timothy Bricker J, Chaitman BR, Fletcher GF, Froelicher VF et al. ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines), Circulation 2002; 106; 1883–1892 http://dx.doi.org/10.1161/01.CIR.0000034670.06526.15[Crossref]
  • [2] Primeau M. Taillefer R, Essiambre R, Lambert R, Honos G. Technetium 99m Sestamibi myocardial perfusion imaging: comparison between treadmill, dipyridamole and trans-oesophageal atrial pacing “stress” tests in normal subjects, Eur J Nucl Med 1991; 18: 247–251 http://dx.doi.org/10.1007/BF00186648[Crossref]
  • [3] Brown KA, Rowen M. Impact of antianginal medications, peak heart rate and stress level on the prognostic value of a normal exercise myocardial perfusion imaging study, J Nucl Med 1993; 34: 1467–1471
  • [4] Verzijlbergen JF, Vermeersch PHMJ, Laarman G, Ascoop CAPL. Inadequate exercise leads to suboptimal imaging. Thallium-201 myocardial perfusion imaging after dipyridamole combined with low-level exercise unmasks ischemia in symptomatic patients with non diagnostic thallium-201 scan who exercise submaximally, J Nucl Med 1991; 32: 2071–2078
  • [5] McLaughlin PR, Martin RP, Doherty P et al. Reproducibility of thallium-201 myocardial imaging, Circulation 1977; 55: 497–503
  • [6] Manganelli F, Spadafora M, Varrella P et al. Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischemia with SPECT imaging: a randomized placebo-controlled trial, Eur J Nucl Med Mol Imaging 2011; 38: 245–251 http://dx.doi.org/10.1007/s00259-010-1641-8[Crossref]
  • [7] Gibbons RJ, Balady GJ, Beasley JW et al. ACC/AHA guidelines for exercise testing, J Am Coll Cardiol 1997; 30: 260–3111 http://dx.doi.org/10.1016/S0735-1097(97)00150-2[Crossref]
  • [8] Iskandrian AS, Heo J, Kong B, Lyons E. The effect of exercise level on the ability of thallium-201 tomographic imaging in detecting coronary artery disease: analysis of 461 patients, J Am Coll Cardiol 1989; 14: 1477–1486 http://dx.doi.org/10.1016/0735-1097(89)90385-9[Crossref]
  • [9] Gauri AJ, Raxwal VK, Roux L et al. Effects of chronotropic incompetence and beta-blocker use on the exercise treadmill test in men, Am Heart J 2001; 142: 136–141 http://dx.doi.org/10.1067/mhj.2001.115788[Crossref]
  • [10] White MP. Pharmacologic stress testing: understanding the options, J Nucl Cardiol 1999; 6: 672–675 hyperactivity?), Circulation 1996; 93: 1485–1487 [Crossref]
  • [11] Sarullo FM, Schicchi R, Schirò M et al. Comparative evaluation of dobutamine-atropine stress echocardiography with exercise testing for detection of coronary artery disease [in Italian], G Ital Cardiol 1996; 26: 1279–1290
  • [12] McNeill AJ, Fioretti PM, el-Said SM et al. Enhanced sensitivity for detection of coronary artery disease by addition of atropine to dobutamine stress echocardiography, Am J Cardiol 1992; 70: 41–46 http://dx.doi.org/10.1016/0002-9149(92)91387-J[Crossref][WoS]
  • [13] Secknus MA, Marwick TH. Evolution of dobutamine echocardiography protocols and indications: safety and side effects in 3011 studies over 5 years, J Am Coll Cardiol 1997; 29: 1234–1240 http://dx.doi.org/10.1016/S0735-1097(97)00039-9
  • [14] Geleijnse ML, Elhendy A, van Domburg RT et al. Cardiac imaging for risk stratification with dobutamine -atropine stress testing in patients with chest pain: echocardiography, perfusion scintigraphy, or both?, Circulation 1997; 96: 137–147 [Crossref]
  • [15] Elhendy A, Valkema R, van Domburg RT et al. Safety of dobutamine-atropine stress myocardial perfusion scintigraphy, J Nucl Med 1998; 39: 1662–1666 [PubMed]
  • [16] Elhendy A, van Domburg RT, Bax JJ et al. The functional significance of chronotropic incompetence during dobutamine stress test, Heart 1999; 81: 398–403 [Crossref]
  • [17] Geleijnse ML, Elhendy A, Fioretti PM, Roelandt JRTC. Dobutamine stress myocardial perfusion imaging, Am Coll Cardiol 2000; 36: 2017–2027 http://dx.doi.org/10.1016/S0735-1097(00)01012-3[Crossref]
  • [18] Elhendy A, van Domburg RT, Bax JJ et al. Safety, hemodynamic profile, and feasibility of dobutamine stress technetium myocardial perfusion single- photon emission CT imaging for evaluation of coronary artery disease in the elderly, Chest 2000; 117: 649–656 http://dx.doi.org/10.1378/chest.117.3.649[Crossref]
  • [19] Ellestad MH, Wan MK. Predictive implications of stress testing: follow-up of 2700 subjects after maximum treadmill stress testing, Circulation 1975; 51: 363–369
  • [20] Myers J, Prakash M, Froelicher V. Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing, N Engl J Med 2002; 3546: 793–801 http://dx.doi.org/10.1056/NEJMoa011858[Crossref]
  • [21] Ledenheim ML, Pollock BH, Rozanshi A et al. Extent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease, J Am Coll Cardiol 1986; 7: 464–471 http://dx.doi.org/10.1016/S0735-1097(86)80454-5[Crossref]
  • [22] Hachamovitch R, Berman DS, Kiat H et al. Exercise myocardial perfusion SPECT in patients without known coronary artery disease. Incremental prognostic value and use in risk stratification, Circulation 1996; 93: 905–914 [Crossref]
  • [23] Schinkel AF, Elhendy A, van Domburg RT. Prognostic value of dobutamine-atropine stress (99m) Tc-tetrofosmin myocardial perfusion SPECT in patients with known or suspected coronary artery disease, J Nucl Med 2002; 43: 767–772
  • [24] Tsutsui JM, Osorio AFF, Lario FC et al. Comparison of safety and efficacy of the early injection of atropine during dobutamine stress echocardiography with the conventional protocol, Am J Cardiol 2004; 94: 1367–1372 http://dx.doi.org/10.1016/j.amjcard.2004.07.141[Crossref]
  • [25] Caner B, Karanfil A, Uysal U. Effect of an additional atropine injection during dobutamine infusion for myocardial SPECT, Nucl Med Commun 1997; 18: 567–573 http://dx.doi.org/10.1097/00006231-199706000-00012[Crossref]
  • [26] Sarullo FM, Ventimiglia C, Taormina A et al. Safety and feasibility of atropine added in patients with sub-maximal heart rate during exercise myocardial perfusion SPECT, Int J Cardiovasc Imaging 2007; 23: 511–518 http://dx.doi.org/10.1007/s10554-006-9169-5[Crossref]
  • [27] David D, Lang RM, Borow KM. Clinical utility of exercise, pacing, and pharmacologic stress testing for the noninvasive determination of myocardial contractility and reserve, Am Heart J 1988; 116: 235–247 http://dx.doi.org/10.1016/0002-8703(88)90284-0[Crossref]
  • [28] Katzung BG. Basic and clinical pharmacology, New York: Lange Medical, McGraw-Hill; 2001 p. 115
  • [29] Variola A, Albiero R, Dander B, Buonanno C. Exercise testing with atropine [in Italian], G Ital Cardiol 1997; 27: 255–262
  • [30] Munagala VK, Guduguntla V, Kasravi B, Cummings G, Gardin JM. Use of atropine in patients with chronotropic incompetence and poor exercise capacity during treadmill stress testing, Am Heart J 2003; 145: 1046–1050 http://dx.doi.org/10.1016/S0002-8703(02)94703-4[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.