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2012 | 7 | 2 | 137-141

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Vaccination in children with cancer: a debate


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Children with malignancy present an important alteration of the immune system functionality caused by the illness itself and by the therapy they undergo. Therefore, they are at high risk of contracting vaccine-preventable diseases and of developing important complications. Vaccinations represent valid devices against these infections but this condition involves two main problems: are vaccines safe in these patients? Are vaccines effective in these patients? The aim of this review is to discuss the principles of vaccination management in children with cancer.











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1 - 4 - 2012
3 - 2 - 2012


  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy
  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy
  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy
  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy
  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy
  • Pediatric Oncology Division, Catholic University, “A. Gemelli” Hospital, 00168, Rome, Italy


  • [1] Borella L., Webster R.G. The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission, Cancer Res., 1971, 31, 420–426
  • [2] Mackall C.L. T-cell immunodeficiency following cytotoxic anti-neoplastic therapy: A review, Stem Cell, 2000, 18, 10–18 http://dx.doi.org/10.1634/stemcells.18-1-10[Crossref]
  • [3] Mackall C.L., Fleisher T.A., Brown M.R., Magrath I.T., Shad A.T., Horowitz M.E., et al., Lymphocyte depletion during treatment with intensive chemotherapy for cancer, Blood, 1994, 84, 2221–2228
  • [4] Mustafa M.M., Buchanan G.R., Winick N.J., McCracken G.H., Tkaczewski I., Lipscomb M., et al., Immune recovery in children with malignancy after cessation of chemotherapy, J. Pediatr. Hematol. Oncol., 1998, 20, 451–457 http://dx.doi.org/10.1097/00043426-199809000-00008[Crossref]
  • [5] Goyal S., Pai S.K., Kelkar R., Advani S.H. Hepatitis B vaccination in acute lymphoblastic leukemia, Leuk. Res., 1998, 22, 193–195 http://dx.doi.org/10.1016/S0145-2126(97)00155-0[Crossref]
  • [6] Yetgin S., Tunç B., Koç A., Toksoy H.B., Ceyhan M., Kanra G. Two booster dose hepatitis B virus vaccination in patients with leukemia, Leuk. Res. 2001, 25, 647–649 http://dx.doi.org/10.1016/S0145-2126(00)00101-6[Crossref]
  • [7] Katz J., Walter B.N., Bennetts G.A. Abnormal cellular and humoral immunity in childhood acute lymphoblastic leukemia in long-term remission, West J. Med. 1987, 146, 179–187
  • [8] Layward L., Levinsky R.J., Butler M. Long-term abnormalities in T and B lymphocyte function in children following treatment for acute lymphoblastic leukaemia, Br. J. Haematol. 1981, 49, 251–258 http://dx.doi.org/10.1111/j.1365-2141.1981.tb07221.x[Crossref]
  • [9] National Institute of Allergy and Incfetious Diseases. 2011 available at: http://www.niaid.nih.gov/topics/vaccines/Pages/Default.aspx
  • [10] Smith S., Schiffman G., Karayalcin G., Bonagura V. Immunodeficiency in long-term survivors of acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster therapy, J. Pediatr. 1995, 127, 68–75 http://dx.doi.org/10.1016/S0022-3476(95)70259-8[Crossref]
  • [11] Mitus A., Holloway A., Evans A.E., Enders J.F. Attenuated measles vaccine in children with acute leukemia, Am. J. Dis. Child 1962, 103, 413–418
  • [12] American Academy of Pediatrics. Varicella-zoster infections. In: Pickering LK, Baker CJ, Kimberlin DW, et al editors (2009) Red Book: 2009 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; pp714–727
  • [13] Caniza M.A., et al., The controversy of varicella vaccination in children with acute lymphoblastic leukemia, Pediatr. Blood Cancer, 2010, (Epub ahead of print) [WoS]
  • [14] Sevinir B., Meral A., Günay U., Ozkan T., Ozuysal S., Sinirtas M. Increased risk of chronic hepatitis in children with cancer, Med. Pediatr. Oncol., 2003, 40, 104–110 http://dx.doi.org/10.1002/mpo.10090[Crossref]
  • [15] O’Brien K.L., Swift A.J., Winkelstein J.A., Santosham M., Stover B., Luddy R., et al., Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM(197) among infants with sickle cell disease. Pneumococcal Conjugate Vaccine Study Group, Pediatrics, 2000, 106, 965–972
  • [16] American Academy of Pediatrics. In: Pickering LK, Baker CJ, Long SS, et al (2006) eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics.
  • [17] Pinkerton R. Flu vaccination for children receiving or recently completing chemotherapy was effective, Arch. Dis. Child Educ. Pract. Ed 2010, 95, 198. Epub 2010 Nov 3 http://dx.doi.org/10.1136/adc.2010.192419[Crossref]
  • [18] Donaldson S.S., Glatstein E., Vosti K.L. Bacterial infections in pediatric Hodgkin’s disease: relationship to radiotherapy, chemotherapy and splenectomy, Cancer, 1978, 41, 1949–1958 http://dx.doi.org/10.1002/1097-0142(197805)41:5<1949::AID-CNCR2820410539>3.0.CO;2-K[Crossref]
  • [19] Esposito S., Cecinati V., Scicchitano B., Delvecchio G.C., Santoro N., Amato D., et al., Impact of influenza-like illness and effectiveness of influenza vaccination in oncohematological children who have completed cancer therapy, Vaccine, 2010, 10,28, 1558–1565. Epub 2009 Dec 8 http://dx.doi.org/10.1016/j.vaccine.2009.11.055[Crossref]
  • [20] Allen U.D. Immunizations for children with cancer, Pediatr. Blood Cancer, 2007, 49, 1102–1108 http://dx.doi.org/10.1002/pbc.21346[Crossref]
  • [21] Pollyea D.A., Brown J.M., Horning S.J. Utility of influenza vaccination for oncology patients, J. Clin. Oncol., 2010, 10,28, 2481–2490. Epub 2010 Apr 12 http://dx.doi.org/10.1200/JCO.2009.26.6908[Crossref]
  • [22] Meral A., Sevinir B., Günay U. Efficacy of immunization against hepatitis B virus infection in children with cancer, Med. Pediatr. Oncol., 2000, 35, 47–51 http://dx.doi.org/10.1002/1096-911X(200007)35:1<47::AID-MPO8>3.0.CO;2-N[Crossref]
  • [23] Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, et al., Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood 2005, 106, 1749–1754 http://dx.doi.org/10.1182/blood-2005-03-1082[Crossref]

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