Analyzing selected risk factors for the development of kidney cancer

• Authors: Helena Kollárová , Kateřina Azeem-Skřejpková , Hana Tomášková , Dagmar Horáková , Silvie Magnusková , Vladimír Janout
• Languages of publication: EN

Abstracts

EN

The aim of this study was to determine influence of selected lifestyle factors on kidney cancer. The study brings data from two centres of international multicentric hospital-based analytical observational case-control studies. Data were obtained from a group of 300 patients newly diagnosed with kidney cancer (ICD-O-2 code C64) and 335 controls from two centres in the Czech Republic. Results showed that smoking increased OR to 1.09 (95% CI 0.77–1.55) and 1.06 (95% CI 0.73–1.52), but the results were not statistically significant. Obesity (BMI⩾30) created adjusted OR 1.71 (95% CI 1.11–2.66) and 1.44 (95% CI 0.91–2.28), showing a minor, statistically insignificant, effect of obesity on the development of kidney cancer. For hypertension, adjusted OR was 1.73 (95% CI 1.25–2.40), suggesting a minor to moderate effect of hypertension on kidney cancer. The analysis results showed a positive association between hereditary predisposition and the development of kidney cancer with an OR of 1.97 (95% CI 1.41–2.76) and 1.97 (95% CI 1.40–2.77) depending on the model of adjustment. The reasons for the high incidence of kidney cancer are not fully understood. Genetic polymorphisms, together with other lifestyle and environmental factors, are likely to contribute to various rates of kidney cancer incidence throughout the world.

Keywords

EN

Kidney cancer; Smoking; Obesity; Hypertension; Hereditary predisposition

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2012
• Volume: 7
• Issue: 1
• Pages: 78-84

Dates

published

1 - 2 - 2012

online

24 - 11 - 2011

Contributors

author

Helena Kollárová

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Kateřina Azeem-Skřejpková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Hana Tomášková

• Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic

author

Dagmar Horáková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Silvie Magnusková

• Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

author

Vladimír Janout

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Identifiers

DOI

10.2478/s11536-011-0111-4