Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2011 | 6 | 6 | 783-787

Article title

Dietary micronutrients and gastric cancer: hospital based study


Title variants

Languages of publication



The association between micronutrients and gastric cancer is still unclear. The aim of this study is to determine the relationship between dietary intake of micronutrients and risk for gastric cancer. We used data from hospital-based case control study conducted at Clinical Centre Nis (Serbia) from 2005 and 2006. Patients (n=102) with first histologically confirmed gastric cancer and matched non-cancer patients (controls, n=204) were interviewed using structured questionnaire and FFQ (Food frequency questionnaire). Multivariate logistic regression analysis showed a significant positive association between gastric cancer and dietary intake of sodium (OR=6.22; 95%CI 1.99–7.86), but a significant negative association between potassium (OR 0.01; 95%CI 0.00–0.08), iron (OR 0.05; 95%CI 0.01–0.56), vitamin C (OR 0.05; 95%CI 0.01–0.38), vitamin E (OR 0.04; 95%CI 0.01–0.29) and niacin (OR 0.07; 95%CI 0.00–0.38) dietary intake. Intake of phosphorus, calcium, magnesium, zinc, retinol, β carotene, tiamin, vitamin B6, and folic acid was not significantly related to gastric cancer risk.In conclusion, we found that a dietary pattern of high consumption of antioxidants (vitamin C, vitamin E, niacin), iron and potassium and low consumption of foods that are sources of sodium, decreased risk for gastric cancer. Our results require confirmation in future studies.











Physical description


1 - 12 - 2011
8 - 10 - 2011


  • Public Health Institute Nis, Bulevar Dr Zorana Đinđića 50, 18000, Nis, Serbia
  • Public Health Institute Nis, Bulevar Dr Zorana Đinđića 50, 18000, Nis, Serbia
  • Public Health Institute Nis, Bulevar Dr Zorana Đinđića 50, 18000, Nis, Serbia


  • [1] Correa P., Human gastric cancerogenesis: a multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention, Cancer. Res., 1992, 52, 6735–6740
  • [2] Lazarević K., Nagorni A., Rancic N., Milutinovic S., Stosic L., Ilijev I., Dietary factors and risk for gastric cancer: hospital based case control study, J. BUON., 2010, 15, 89–93
  • [3] World Cancer Research Fund/ American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington DC: AICR, 2007
  • [4] Kim HJ., Lee SS., Choi BY., Kim MK., Nitrate intake relative to antioxidant vitamin intake affects gastric cancer risk: a case-control study in Korea, Nutr. Cancer., 2007, 59, 185–191 http://dx.doi.org/10.1080/01635580701460554[Crossref]
  • [5] Kim DS., Lee MS., Kim YS., Kim DH., Bae JM., Shin MH., Ahn YO., Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori, Eur. J. Epidemiol., 2005, 20, 67–71 http://dx.doi.org/10.1007/s10654-004-1027-y[Crossref]
  • [6] Akyon Y., Effect of antioxidants on the immune response of Helicobacter pylori, Clin Microbiol. Infect., 2002, 8, 438–441 http://dx.doi.org/10.1046/j.1469-0691.2002.00426.x[Crossref]
  • [7] Galván-Portillo MV., Cantoral A., Oñate-Ocaña LF., Chen J, Herrera-Goepfert R., Torres-Sanchez L., et al., Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers, Eur. J Nutr., 2009, 48, 269–276 http://dx.doi.org/10.1007/s00394-009-0010-5[WoS][Crossref]
  • [8] Prá D., Rech Franke SI., Pegas Henriques JA., Fenech M., A possible link between iron deficiency and gastrointestinal carcinogenesis, Nutr. Cancer, 2009, 61, 415–426 http://dx.doi.org/10.1080/01635580902803701[Crossref][WoS]
  • [9] Donma O., Donma MM., Sonmez S., Metal speciation, phytochemicals and Helicobacter pylori infection, Med. Hypotheses., 2006, 67, 545–549 http://dx.doi.org/10.1016/j.mehy.2006.02.045[Crossref]
  • [10] Willett W. Nutritional Epidemiology. Oxford: Oxford University Press, 1990
  • [11] Jokic N, Dimić M, Pavlica M. Tablice hemijskog sastava prehrambenih proizvoda. Zavod za ekonomiku domaćinstva Srbije. Beograd, 1999. in Serbian
  • [12] USDA (U.S. Deparment of Agriculture Research Service). USDA National Nutrient Database for Standard Reference, Release 17. 2004. accessed 1 December 2007. Available: http://www.nal.usda.gov/fnic/foodcomp/Data/SR17/sr17.html
  • [13] Bjelakovic G., Nikolova D., Simonetti RG., Gluud C., Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements, Aliment. Pharmacol. Ther., 2008, 15, 689–703 http://dx.doi.org/10.1111/j.1365-2036.2008.03785.x[WoS][Crossref]
  • [14] WCRF/AICR. Food, nutrition and the prevention of cancer: a global perspective. World Cancer Research Fund in Association with American Institute for Cancer Research. Washington DC: WCRF/AICR, 1997
  • [15] Kaaks R., Tuyns AJ., Haelterman M., Riboli E., Nutrient intake patterns and gastric cancer risk: a case-control study in Belgium, Int. J. Cancer., 1998, 78, 415–420 http://dx.doi.org/10.1002/(SICI)1097-0215(19981109)78:4<415::AID-IJC4>3.0.CO;2-X[Crossref]
  • [16] Chen H., Tucker KL., Graubard BI., Heineman EF., Markin RS., Potischman NA., et al., Nutrient intakes and adenocarcinoma of the esophagus and distal stomach, Nutr. Cancer., 2002, 42, 33–40 http://dx.doi.org/10.1207/S15327914NC421_5[Crossref]
  • [17] Ekström AM., Serafini M., Nyrén O., Hansson LE, Ye W., Wolk A., Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden, Int. J. Cancer., 2000, 87, 133–140 http://dx.doi.org/10.1002/1097-0215(20000701)87:1<133::AID-IJC20>3.0.CO;2-E[Crossref]
  • [18] Lissowska J., Gail MH., Pee D., Groves FD., Sobin LH., Nasierowska-Guttmejer A, et al., Diet and stomach cancer risk in Warsaw, Poland. Nutr. Cancer., 2004, 48, 149–159 http://dx.doi.org/10.1207/s15327914nc4802_4[Crossref]
  • [19] Pelucchi C., Tramacere I., Bertuccio P., Tavani A, Negri E., La Vecchia C., Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study, Ann. Oncol., 2009, 20, 160–165 http://dx.doi.org/10.1093/annonc/mdn536[WoS][Crossref]
  • [20] Zheng W., Sellers TA., Doyle TJ., Kushi LH., Potter JD., Folsom AR., Retinol, antioxidant vitamins, and cancers of the upper digestive tract in a prospective cohort study of postmenopausal women, Am. J. Epidemiol., 1995, 142, 955–960
  • [21] Nouraie M., Pietinen P., Kamangar F., Dawsey SM., Abnet CC., Albanes D., et al., Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers, Cancer. Epidemiol. Biomarkers. Prev., 2005, 14, 2087–2092 http://dx.doi.org/10.1158/1055-9965.EPI-05-0038[Crossref]
  • [22] Botterweck AA., van den Brandt PA., Goldbohm RA., Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up, Cancer., 2000, 88, 737–748 http://dx.doi.org/10.1002/(SICI)1097-0142(20000215)88:4<737::AID-CNCR2>3.0.CO;2-H[Crossref]
  • [23] Jenab M., Riboli E., Ferrari P., Sabate J., Slimani N., Norat T., et al., Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST), Carcinogenesis., 2006, 27, 2250–2257 http://dx.doi.org/10.1093/carcin/bgl096[Crossref][WoS]
  • [24] Cherng JM., Shieh DE., Chiang W., Chang MY., Chiang LC., Chemopreventive effects of minor dietary constituents in common foods on human cancer cells, Biosci. Biotechnol. Biochem., 2007; 71(6):1500–1504 http://dx.doi.org/10.1271/bbb.70008[Crossref][WoS]
  • [25] Lee SY., Shin YW., Hahm KB., Phytoceuticals: Mighty but ignored weapons against Helicobacter pylori infection, J. Dig. Dis., 2008, 9, 129–139 http://dx.doi.org/10.1111/j.1751-2980.2008.00334.x[Crossref]
  • [26] Jiang Q., Christen S., Shigenaga MK., Ames BN., gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention, Am. J. Clin. Nutr., 2001, 74, 714–722
  • [27] Liu HK., Wang Q., Li Y., Sun WG., Liu JR., Yang YM., et al., Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells, J Nutr Biochem., 2009, 21, 206–213 http://dx.doi.org/10.1016/j.jnutbio.2008.11.004[WoS][Crossref]
  • [28] Sun W., Wang Q., Chen B., Liu J., Liu H., Xu W., Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. Br. J. Nutr., 2008, 99, 1247–1254 http://dx.doi.org/10.1017/S0007114507879128[WoS][Crossref]
  • [29] Chun J., Lee J., Ye L., Exler J., Eitenmiller R.R. Tocopherol and tocotrienol contents of raw and processed fruits and vegetables in the United States diet, Journal of Food Composition and Analysis, 2006, 19, 196–204 http://dx.doi.org/10.1016/j.jfca.2005.08.001[Crossref]
  • [30] Harrison LE., Zhang ZF., Karpeh MS., Sun M., Kurtz RC., The role of dietary factors in the intestinal and diffuse histologic subtypes of gastric adenocarcinoma: a case-control study in the U.S, Cancer, 1997, 80, 1021–1028 http://dx.doi.org/10.1002/(SICI)1097-0142(19970915)80:6<1021::AID-CNCR3>3.0.CO;2-C[Crossref]
  • [31] Nomura AM., Hankin JH., Kolonel LN., Wilkens LR., Goodman MT., Stemmermann GN., Case-control study of diet and other risk factors for gastric cancer in Hawaii (United States), Cancer. Causes. Control., 2003, 14, 547–558 http://dx.doi.org/10.1023/A:1024887411846[Crossref]
  • [32] Qiu JL., Chen K., Zheng JN., Wang JY., Zhang LJ., Sui LM., Nutritional factors and gastric cancer in Zhoushan Islands, China. World. J. Gastroenterol., 2005, 11, 4311–4316
  • [33] Lunet N., Valbuena C., Carneiro F., Lopes C., Barros H., Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal, Nutr. Cancer, 2006, 55, 71–77 http://dx.doi.org/10.1207/s15327914nc5501_9[Crossref]
  • [34] Ji BT., Chow WH., Yang G., McLaughlin JK., Zheng W., Shu XO., et al., Dietary habits and stomach cancer in Shanghai, China, Int. J. Cancer., 1998, 76, 659–664. http://dx.doi.org/10.1002/(SICI)1097-0215(19980529)76:5<659::AID-IJC8>3.0.CO;2-P[Crossref]
  • [35] Lopez-Carrillo L., Lopez-Cervantes M., Ward MH., Bravo-Alvarado J., Ramirez-Espitia A., Nutrient intake and gastric cancer in Mexico, Int. J. Cancer, 1999, 83:601–605 http://dx.doi.org/10.1002/(SICI)1097-0215(19991126)83:5<601::AID-IJC5>3.0.CO;2-6[Crossref]
  • [36] Mayne ST., Risch HA., Dubrow R., Chow WH., Gammon MD., Vaughan TL., et al., Nutrient intake and risk of subtypes of esophageal and gastric cancer, Cancer. Epidemiol. Biomarkers. Prev., 2001, 10, 1055–1062
  • [37] Jenab M., Riboli E., Ferrari P., Friesen M., Sabate J., Norat T., et al. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition, Br. J. Cancer., 2006, 95, 406–415 http://dx.doi.org/10.1038/sj.bjc.6603266[Crossref]
  • [38] Carman S., Kamangar F., Freedman ND., Wright ME., Dawsey SM., Dixon LB., et al., Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study, Int. J. Cancer., 2009, 125, 165–170 http://dx.doi.org/10.1002/ijc.24342[Crossref]
  • [39] Muñoz N., Plummer M., Vivas J., Moreno V., De Sanjosé S., Lopez G., et al. A case-control study of gastric cancer in Venezuela, Int J Cancer., 2001, 93, 417–423 http://dx.doi.org/10.1002/ijc.1333[Crossref]
  • [40] Palli D., Russo A., Decarli A., Dietary patterns, nutrient intake and gastric cancer in a high-risk area of Italy. Cancer. Causes. Control., 2001, 12, 163–172 http://dx.doi.org/10.1023/A:1008970310963[Crossref]
  • [41] Salgueiro J., Zubillaga M., Goldman C., Barrado A., Martinez Sarrasague M., Leonardi N., Boccio J., Review article: is there a link between micronutrient malnutrition and Helicobacter pylori infection?, Aliment. Pharmacol. Ther., 2004, 20, 1029–1034 http://dx.doi.org/10.1111/j.1365-2036.2004.02265.x[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.