Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

• Authors: Vesna Nikolic , Ivan Savic , Ivana Savic , Ljubisa Nikolic , Mihajlo Stankovic , Valentina Marinkovic
• Languages of publication: EN

Abstracts

EN

Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.

Keywords

EN

Paclitaxel; Isolation; Activity; Synthesis; Complexation

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 5
• Pages: 527-536

Dates

published

1 - 10 - 2011

online

9 - 8 - 2011

Contributors

author

Vesna Nikolic

• Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

author

Ivan Savic

• Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

author

Ivana Savic

• Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

author

Ljubisa Nikolic

• Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

author

Mihajlo Stankovic

• Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

author

Valentina Marinkovic

• Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Serbia

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Identifiers

DOI

10.2478/s11536-011-0074-5