Genome-wide linkage scan of major depressive disorder in two Dagestan genetic isolates

• Authors: Kazima Bulayeva , Todd Lencz , Stephen Glatt , Toru Takumi , Farida Gurgenova , Oleg Bulayev
• Languages of publication: EN

Abstracts

EN

We conducted a 10-cM genome-wide linkage scan in two extended pedigrees, ascertained from two diverse Dagestan genetic isolates with high aggregation of major depressive disorder (MDD) and suicides. Using genome wide multipoint parametric linkage analyses with short tandem repeat markers, we found two previously undetected genomic regions with significant linkage in isolate #6007 with LODs=3.1–3.4 at 2p13.2–p11.2 (and some signal in same region for #6008) and in 14q31.12–q32.13. We also obtained suggestive evidence for linkage with MDD at 9q33.3–q34.2 (#6008), 13q31.1–q31.2(#6007), 11p15(#6008), 17q25.3(#6007) and 19q13.31–q13.33 (#6008). Five regions (1p36.1–p35.2, 2p13.2–p11.2, 17q25.3, 18q22 and 22q12.3) demonstrated at least nominal linkage in both isolates’ pedigrees, while all other linkage regions demonstrated population-specific genetic heterogeneity.

Keywords

EN

Major Depressive Disorder; Early onset; Genetic isolates; Multipoint linkage analysis; Cross-isolates mapping; Suicides committed

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 5
• Pages: 616-624

Dates

published

1 - 10 - 2011

online

9 - 8 - 2011

Contributors

author

Kazima Bulayeva

• N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

author

Todd Lencz

• Division of Psychiatry Research, The Zucker Hillside Hospital, New York, NY, 11004, USA

author

Stephen Glatt

• Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA

author

Toru Takumi

• Hiroshima University, Kasumi 1-2-3, Hiroshima, 734-8553, Japan

author

Farida Gurgenova

• N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

author

Oleg Bulayev

• N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

References

• [1] Kim S, Choi KH, Baykiz AF, Gershenfeld HK. Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC genomics 2007;8:413 http://dx.doi.org/10.1186/1471-2164-8-413[Crossref]
• [2] Sullivan P, Neale M, Kendler K. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000;157(10):1552–1562 http://dx.doi.org/10.1176/appi.ajp.157.10.1552[Crossref]
• [3] Glowinski A, Madden P, Bucholz K et al. Genetic epidemiology of self-reported lifetime DSM-IV major depressive disorder in a population-based twin sample of female adolescents. J Child Psychol Psychiatry 2003;44(7):988–996 http://dx.doi.org/10.1111/1469-7610.00183[Crossref]
• [4] Kato T. Molecular genetics of bipolar disorder and depression. Pscyhiatry and Clinical Neurosciences 2007;61:1–17 http://dx.doi.org/10.1111/j.1440-1819.2007.01627.x[Crossref][WoS]
• [5] Zubenko G, Hughes H, Stiffler J et al. Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10 cM resolution. Am J Med Genet 2002;114:413–422 http://dx.doi.org/10.1002/ajmg.10381[Crossref]
• [6] Kendler KS, Thornton LM, Gardner CO. Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. American Journal of Psychiatry 2001;158:582–586 http://dx.doi.org/10.1176/appi.ajp.158.4.582[Crossref]
• [7] Abkevich V, Camp N, Hensel C et al. Predisposition Locus for Major Depression at Chromosome 12q22–12q23.2. Am J Hum Genet 2003;73:1271–1281 http://dx.doi.org/10.1086/379978[Crossref]
• [8] Holmans P, Zubenko G, Crowe R et al. Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. Am J Hum Genet 2004;74(6):1154–1167 http://dx.doi.org/10.1086/421333[Crossref]
• [9] Kia-Keating B, Glatt S, Tsuang M. Meta-Analyses Suggest Association Between COMT, but Not HTR1B, Alleles, and Suicidal Behavior. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 2007;144(B):1048–1053 http://dx.doi.org/10.1002/ajmg.b.30551[WoS][Crossref]
• [10] Levinson D. The genetics of depression. Biologial Psychiatry 2006;60(2):84–92 http://dx.doi.org/10.1016/j.biopsych.2005.08.024[Crossref]
• [11] Bulayeva KB, Leal SM, Pavlova TA et al. Mapping genes of complex psychiatric diseases in Daghestan genetic isolates. Am J Med Genet 2005;132B(1):Pages 76–84 http://dx.doi.org/10.1002/ajmg.b.30073[Crossref]
• [12] Bulayeva KB, Glatt SJ, Bulayev OA et al. Genomewide linkage scan of schizophrenia: a cross-isolate study. Genomics 2007;89(2):167–177 http://dx.doi.org/10.1016/j.ygeno.2006.10.001[WoS][Crossref]
• [13] Bulayeva K, Pavlova T, Kurbanov R, Bulaev O. [Mapping genes of complex diseases in genetic isolates of Dagestan] Kartirovanie genov kompleksnykh zabolevanii v geneticheskikh izoliatakh Dagestana. Genetika 2002;38(11):1539–1548
• [14] Bulayeva K, Jorde LB, Ostler C et al. Genetics and population history of Caucasus populations. Hum Biol 2003;75(6):837–853 http://dx.doi.org/10.1353/hub.2004.0003[Crossref]
• [15] Nurnberger J, Blehar M, Kaufman C et al. Diagnostic interview for genetic studies: rationale, unique features and training. Arch Gen Psychiatry 1994;51:849–862
• [16] Bulayeva KB, Pavlova TA, Kurbanov RM, Bulaev OA. [Mapping genes of complex diseases in genetic isolates of Dagestan]. Genetika 2002;38(11):1539–1548
• [17] Association AP. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Press; 1994
• [18] Weber JL, Wang Z, Hansen K, et al. Evidence for Human Meiotic Recombination: Interference Obtained through Construction of a Short Tandem Repeat-Polymorphism Linkage Map of Chromosome 19. Am J Hum Genet, 1993;53:1079–1095
• [19] Sobel E, Lange K. Descent Graphs in Pedigree Analysis: Applications to Haplotyping, Location Scores, and Marker Sharing Statistics. Am J Hum Genet 1996;58:1323–1337 [PubMed]
• [20] Bulayeva KB, Leal SM, Pavlova TA et al. Mapping genes of complex psychiatric diseases in Daghestan genetic isolates. Am J Med Genet B Neuropsychiatr Genet 2005;132(1):76–84
• [21] Bulayev O, Spitzin V, Bulayeva K. Population approach to mapping genes of complex diseases. J MedGenetics (Russia) 2009;4:3–17.
• [22] Bulayeva K, Jorde L, Ostler C et al. Genetics and population history of Caucasus populations. Hum Biol 2003;75(6):837–853. http://dx.doi.org/10.1353/hub.2004.0003[Crossref]
• [23] Bulayeva KB, Pavlova TA, Bulaev OA. [Genetic polymorphism in three indigenous ethnic populations of Dagestan]. Genetika 1997;33(10):1395–1405
• [24] Oquendo MA, Ellis SE, Greenwald BS et al. Ethnic and Sex Differences in Suicide Rates Relative to Major Depression in the United States. Am J Psychiatry 2001;158:1652–1658 http://dx.doi.org/10.1176/appi.ajp.158.10.1652[Crossref]
• [25] Drago A, De Ronchi D, Sorretti A. Incomplete coverage of candidate genes: a poorly considered bias. Current Genomics 2007;8(7):476–483 http://dx.doi.org/10.2174/138920207783591681[Crossref]
• [26] Potash J, Buervenich S, Cox N et al. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. Am J Med Genet B Neuropsychiatr Genet 2008;147B(1):59–67
• [27] Liu Y, Fann C, Liu C et al. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. Biological psychiatry 2008;64(9):789–796 http://dx.doi.org/10.1016/j.biopsych.2008.04.035[WoS][Crossref]
• [28] Culjkovic B, Stojkovic O, Savic D et al. Comparison of the number of triplets in SCA1, MJD/SCA3, HD, SBMA, DRPLA, MD, FRAXA and FRDA genes in schizophrenic patients and a healthy population. American journal of medical genetics 2000;96(6):889–894 http://dx.doi.org/10.1002/1096-8628(20001204)96:6<884::AID-AJMG41>3.0.CO;2-M[Crossref]
• [29] Shi J, Potash J, Knowles J et al. Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry 2010;Feb 2. [Epub ahead of print] [WoS]

Identifiers

DOI

10.2478/s11536-011-0071-8