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2011 | 6 | 4 | 418-424

Article title

Diameter of the ductus arteriosus as a predictor of patent ductus arteriosus (PDA)


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Patent ductus arteriosus (PDA) is the most prevalent cardiovascular defect and is more often seen in females; premature babies are at increased risk. For both sexes, a relationship exists between the risk of this defect occurring and the higher dimensions of the ductus arteriosus. In this study, we examined the relationship between the dimensions of the ductus arteriosus (diameter, length, capacity) and sex. We analyzed a total of 223 fetuses, 108 males and 115 females, ranging in age from four to eight months of intrauterinal life. All fetuses of normal karyotype were obtained from spontaneous abortions. None of the analyzed specimens demonstrated any visible malformations. The increase in the length and diameters of the ductus is linearly related to gestational age. The volumetric growth of this vessel was dependent on fetal age, according to the exponential function. The large number of analyzed specimens allows reliable determination of the ductus arteriosus dimensions in consecutive months of fetal life. The data obtained could be of prognostic value during echocardiographic follow-up in the fetus. We found that the dimensions analyzed did not differ with regard to sex. It is a contradiction that, more frequently PDA in females is caused with the gender differences in the dimensions of ductus arteriosus.










Physical description


1 - 8 - 2011
1 - 6 - 2011


  • Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, PL-85-092, Toruń, Poland
  • Department of Anatomy, Medical Faculty, University of Varmia and Masuria in Olsztyn, 10-082, Olsztyn, Poland
  • Department of Anatomy, Medical Faculty, University of Varmia and Masuria in Olsztyn, 10-082, Olsztyn, Poland


  • [1] Sadler T.W.; Langman’s Medical Embryology. 11th Edition. Wolters Kluwer Health/Lippincott, Wiliams & Wilkins, Philadelphia, Baltimor, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo. 2009
  • [2] Yagel S., Silverman N.H., Gembruch U.; Fetal cardiology: embryology, genetics, physiology, echocardiographic evaluation, diagnostic and perinatal management of cardiac diseases. Informa Healthcare Publisher, ed 2, London. 2008
  • [3] Clyman R.I.; Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006, 89(4), 330–335 http://dx.doi.org/10.1159/000092870[Crossref]
  • [4] Clyman R.I., Chorne N.; Patent ductus arteriosus: Evidence for and against treatment. J Pediatr. 2007, 150, 216–219 http://dx.doi.org/10.1016/j.jpeds.2006.12.048[Crossref]
  • [5] Hermes-DeSantis E.R., Clyman R.I.; Patent ductus arteriosus: pathophysiology and management. J Perinatol., 2006, 26: S14–S18; discussion S22–3 http://dx.doi.org/10.1038/sj.jp.7211465[Crossref]
  • [6] Freed M.D., Congenital cardiac malformations. In Avery ME, Taeusch HW (eds) Schaffer’s Disease of the Newborn. Philadelphia: WB. Saunders Company, 1984
  • [7] Freedom R.M., Benson L.N., Smallhorn J.F.; Neonatal heart disease. Springer-Verlag, Berlin, Heidelberg, New York, 1992
  • [8] Warnes C.A., Williams R.G., Bashore T.M., Child J.S., Connolly H.M., Dearani J.A., Del Nido P., Fasules J.W., Graham T.P. Jr, Hijazi Z.M., Hunt S.A., King M.E., Landzberg M.J., Miner P.D., Radford M.J., Walsh E.P., Webb G.D.; ACC/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease). Circulation 2008;118:e714 http://dx.doi.org/10.1161/CIRCULATIONAHA.108.190690[Crossref]
  • [9] Kluckow M., Evans N.; Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. J Pediatr., 1995, 127(5), 774–779 http://dx.doi.org/10.1016/S0022-3476(95)70172-9[Crossref]
  • [10] Brown E.R.; Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus. J Pediatr., 1979, 95, 865–866 http://dx.doi.org/10.1016/S0022-3476(79)80454-0[Crossref]
  • [11] Reller M.D., Lorenz J.M., Kotagal U.R., Meyer R.A., Kaplan S.; Hemodynamically significant PDA: an echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance. Pediatr Cardiol., 1985, 6(1), 17–23 http://dx.doi.org/10.1007/BF02265403[Crossref]
  • [12] Stefano J.L., Abbasi S., Pearlman S.A., Spear M.L., Esterly K.L., Bhutani V.K.; Closure of the ductus arteriosus with indomethacin in ventilated neonates with respiratory distress syndrome. Effects of pulmonary compliance and ventilation. Am Rev Respir Dis., 1991; 143(2), 236–239
  • [13] Shimada S., Kasai T., Konishi M., Fujiwara T.; Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant. J Pediatr., 1994, 125(2), 270–277 http://dx.doi.org/10.1016/S0022-3476(94)70210-1[Crossref]
  • [14] Shortland D.B., Gibson N.A., Levene M.I., Archer L.N., Evans D.H., Shaw D.E.; Patent ductus arteriosus and cerebral circulation in preterm infants. Dev Med Child Neurol., 1990, 32(5), 386–393 http://dx.doi.org/10.1111/j.1469-8749.1990.tb16957.x[Crossref]
  • [15] Iffy L., Jakobovits A., Westlake W., Wingate M.B., Caterini H., Kanofsky P., Menduke H.; Early intrauterine development: I. The rate of growth of Caucasian embryos and fetuses between the 6th and 20th weeks of gestation. Pediatrics, 1975, 56, 173–186
  • [16] Szyszka-Mróz J., Woźniak W.; A histological study of human ductus arteriosus during the last embryonic week. Folia Morphol (Warsz)., 2003, 62(4), 365–367
  • [17] van Meurs-van Woezik H., Krediet P.; Measurements of the descending aorta in infants and children: comparison with other aortic dimensions. J Anat., 1982, 135, 273–279
  • [18] Olley P.M.; The ductus arteriosus, its persistence and its patency. In; Anderson RH, Macartney FJ, Shinebourne EA, Tynan M. (Eds) Pediatric Cardiology, Edinburg: Churchill Livingstone, 1987
  • [19] Angelini A., Allan L.D., Anderson R.H., Crawford D.C., Chita S.K., Ho S.Y.; Measurements of the dimensions of the aortic and pulmonary pathways in the human fetus: a correlative echocardiographic and morphometric study. Br. Heart J., 1988, 60, 221–226 http://dx.doi.org/10.1136/hrt.60.3.221[Crossref]
  • [20] Ursell P.C., Byrne J.M., Fears T.R., Strobino B.A., Gersony W.M.; Growth of the great vessels in the normal human fetus and in the fetus with cardiac defects. Circulation, 1991; 84: 2028–2033 [Crossref]
  • [21] Achiron R., Golan-Porat N., Gabbay U., Rotstein Z., Heggesh J., Mashiach S., Lipitz S.: In utero ultrasonographic measurements of fetal aortic and pulmonary artery diameters during the first half of gestation. Ultrasound Obstet. Gynecol., 1998, 11, 180–184. http://dx.doi.org/10.1046/j.1469-0705.1998.11030180.x[Crossref]
  • [22] Achiron R., Zimand S., Hegesh J., Lipitz S., Zalel Y., Rotstein Z.; Fetal aortic arch measurements between 14 and 38 weeks’ gestation: in utero ultrasonographic study. Ultrasound Obstet. Gynecol., 2000, 15, 226–230 http://dx.doi.org/10.1046/j.1469-0705.2000.00068.x[Crossref]
  • [23] Castillo E.H., Arteaga-Martinez M., Garcia-Pelaez I., Villasis-Keever M.A., Aguirre O.M., Moran V., Vizcaino A.; Morphometric study of the human fetal heart. I. Arterial segment. Clin Anat., 2005, 18, 260–268 [Crossref]
  • [24] Gielecki J.S., Wilk R., Syc B., Musiał-Kopiejka M., Piwowarczyk-Nowak A.; Digital-image analysis of the aortic arch’s development and its variations. Folia Morphol (Warsz), 2004, 63(4), 449–454
  • [25] Szpinda M., Szwesta A., Szpinda E.; Morphometric study of the ductus arteriosus during human development. Ann Anat., 2007, 189(1), 47–52 [WoS]
  • [26] Gielecki J.S., Syc B., Wilk R., Musiał-Kopiejka M., Piwowarczyk-Nowak A.; Quantitative evaluation of aortic arch development using digital-image analysis. Ann Anat., 2006, 188(1), 19–23 http://dx.doi.org/10.1016/j.aanat.2005.04.013[Crossref]
  • [27] Alvarez L., Aranega A., Saucedo R., Lopez F., Aranega A.E., Muros M.A.; Morphometric data on the arterial duct in the human fetal heart. Int J Cardiol, 1991, 31, 337–344 http://dx.doi.org/10.1016/0167-5273(91)90385-3[Crossref]
  • [28] Hyett J., Moscoso G., Nicolaides K.; Morphometric analysis of the great vessels in early fetal life. Hum Reprod, 1995, 10, 3045–3048
  • [29] Szpinda M.; Badania morfometryczne wielkich tętnic klatki piersiowej u płodów ludzkich. Rozprawa habilitacyjna. [Morphometric study of the great artery of the chest in human fetus], Wydawnictwo CM UMK, Bydgoszcz, 2006
  • [30] Allan L.D., Cook A.C., Huggon I.C.; Fetal Echocardiography: a practical quide. Cambridge University Press. London, 2009
  • [31] Castaneda A.R., Jonas R.A., Mayer J.E., Hanley F.L.; Cardiac surgery of the neonate and infant. W.B. Saunders Company, 1994
  • [32] Karolczak M.A.; Wykłady o sercu i kardiochirurgii wad wrodzonych. [The lectures about heart and heart surgery of the congenital heart disease]. Wyd 1. Czelej. Lublin. 2008
  • [33] Kubicka K. Kawalec W.; Kardiologia dziecięca. [Pediatric cardiology] Wydanie 1. Wydawnictwo Lekarskie PZWL, Warszawa, 2003
  • [34] Respondek-Liberska M.; Kardiologia prenatalna dla położników i kardiologów dziecięcych. [Prenatal cardiology for obstetricians and children’s cardiologists] Wydawnictwo Czelej, Lublin, 2006
  • [35] Szymankiewicz-Dangel J.; Kardiologia płodu. Zasady diagnostyki i terapii. [Fetal cardiology: diagnostic and therapy]. Ośrodek Wydawnictw Naukowych, Poznań, 2007
  • [36] Mielke G., Benda N.; Reference ranges for twodimensional echocardiographic examination of the fetal ductus arteriosus. Ultrasound Obstet Gynecol, 2000, 15, 219–225 http://dx.doi.org/10.1046/j.1469-0705.2000.00078.x[Crossref]
  • [37] Tan J., Sikverman N.H., Hoffmann J.I.E., Villegas M., Schmidt K.G.; cardiac dimensions determined by cross-sectional echocardiography in the normal human fetus from 18-weeks to term. Am J. Cardiol, 1992, 70, 1459–1467 http://dx.doi.org/10.1016/0002-9149(92)90300-N[Crossref]
  • [38] St John Sutton M., Groves A., MacNeill A., Sharland G., Allan L.; Assessment of changes in blood flow through the lungs and foramen ovale in the normal human fetus with gestational age: a prospective Doppler echocardiographic study. Br Heart J, 1994, 71, 232–237 http://dx.doi.org/10.1136/hrt.71.3.232[Crossref]
  • [39] Rasanen J., Wood D.C., Weiner S., Lubomirski A., Huhta J.C.; Role of the pulmonary circulation in the distribution of the human fetal cardiac output during the second half of preganancy. Circulation 1996, 94, 1068–1073 [Crossref]

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