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2011 | 6 | 4 | 470-474

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Vancomycin-resistant Enterococcus faecium-associated encephalitis and concurrent cerebellitis


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Enterococci are uncommon etiologic agents of central nervous system infections. We describe a case of nosocomial encephalitis and concurrent cerebellitis associated with Enterococcus faecium in a man, with extranodal natural killer/T-cell lymphoma, nasal type, who underwent high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Brain magnetic resonance images showed lesions in the bihemispheral cerebellar cortex with swelling and several small lesions in both cerebral hemispheres. The blood and cerebrospinal fluid cultures were positive for vancomycin-resistant E. faecium. Vancomycin-resistant E. faecium can cause encephalitis and concurrent cerebellitis in an immunocompromised patient who underwent autologous peripheral blood stem cell transplantation.










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1 - 8 - 2011
1 - 6 - 2011


  • Department of Neurology, Eulji General Hospital, 280-1 Hagye 1-dong, Nowon-gu, Seoul, Republic of Korea


  • [1] Beckham J. D., Tyler K. L., Encephalitis, In: Mandell G. L., Bennett J. E., Dolin R., (Eds.), Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 7th ed., Churchill Livingstone/Elsevier, Philadelphia, 2010
  • [2] Willoughby Jr. R. E., Long S. S., Encephalitis, meningoencephalitis, acute disseminated encephalomyelitis, and acute necrotizing encephalopathy, In: Long S. S., Pickering L. K., Prober C. G., (Eds.), Principles and practice of pediatric infectious diseases. 3rd ed., Churchill Livingstone/Elsevier, Philadelphia, 2008
  • [3] Yang T. H., Jeong S. Y., Oh S. Y., Shin B. S., Seo M. W., Kim Y. H., et al., Recurrent Streptococcus Pneumoniae meningoencephalitis in a patient with a transethmoidal meningoencephalocele, J Clin Neurol, 2008, 4, 40–44 http://dx.doi.org/10.3988/jcn.2008.4.1.40[Crossref][WoS]
  • [4] Fluss J., Ferey S., Menache-Starobinski C., Delavelle J., Van Bogaert P., Vargas M. I., Mild influenza-associated encephalopathy/encephalitis with a reversible splenial lesion in a Caucasian child with additional cerebellar features, Eur J Paediatr Neurol, 2010, 14, 97–100 http://dx.doi.org/10.1016/j.ejpn.2009.09.007[WoS][Crossref]
  • [5] Shiihara T., Watanabe M., Honma A., Kato M., Morita Y., Ichiyama T., et al., Rotavirus associated acute encephalitis/encephalopathy and concurrent cerebellitis: report of two cases, Brain Dev, 2007, 29, 670–673 http://dx.doi.org/10.1016/j.braindev.2007.04.005[WoS][Crossref]
  • [6] Ohta K., Funaki M., Tanaka M., Suzuki N., Early cerebellar involvement on diffusion-weighted magnetic resonance images in herpes simplex encephalitis, J Neurol, 1999, 246, 736–738 http://dx.doi.org/10.1007/s004150050444[Crossref]
  • [7] Misra U. K., Kalita J., Movement disorders in Japanese encephalitis, J Neurol, 1997, 244, 299–303 http://dx.doi.org/10.1007/s004150050090[Crossref]
  • [8] Granerod J., Cunningham R., Zuckerman M., Mutton K., Davies N. W., Walsh A. L., et al., Causality in acute encephalitis: defining aetiologies, Epidemiol Infect, 2010, 138, 783–800 http://dx.doi.org/10.1017/S0950268810000725[WoS][Crossref]
  • [9] Zeana C., Kubin C. J., Della-Latta P., Hammer S. M., Vancomycin-resistant Enterococcus faecium meningitis successfully managed with linezolid: case report and review of the literature, Clin Infect Dis, 2001, 33, 477–482 http://dx.doi.org/10.1086/321896[Crossref]
  • [10] Hanson K. L., Cartwright C. P., Comparison of simple and rapid methods for identifying enterococci intrinsically resistant to vancomycin, J Clin Microbiol, 1999, 37, 815–817
  • [11] Shah K. H., Richard K. M., Nicholas S., Edlow J. A., Incidence of traumatic lumbar puncture, Acad Emerg Med, 2003, 10, 151–154 http://dx.doi.org/10.1111/j.1553-2712.2003.tb00033.x[Crossref]
  • [12] Teele D. W., Dashefsky B., Klein J. O., Meningitis after lumbar puncture in children with bacteremia, N Engl J Med, 1982, 306, 608–610 http://dx.doi.org/10.1056/NEJM198203113061012[Crossref]
  • [13] Bayer A. S., Seidel J. S., Yoshikawa T. T., Anthony B. F., Guze L. B., Group D enterococcal meningitis. Clinical and therapeutic considerations with report of three cases and review of the literature, Arch Intern Med, 1976, 136, 883–886 http://dx.doi.org/10.1001/archinte.136.8.883[Crossref]
  • [14] Tunkel, A. R., Scheld, W. M., Acute meningitis, In: Mandell G. L., Bennett J. E., Dolin R., (Eds.), Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 7th ed., Churchill Livingstone/Elsevier, Philadelphia, 2010
  • [15] Herzig R. H., Hines J. D., Herzig G. P., Wolff S. N., Cassileth P. A., Lazarus H. M., et al., Cerebellar toxicity with high-dose cytosine arabinoside, J Clin Oncol, 1987, 5, 927–932
  • [16] Yeshurun M., Marsot Dupuch K., Acute cerebellar syndrome following intermediate-dose cytarabine, Br J Haematol, 2001, 113, 846 http://dx.doi.org/10.1046/j.1365-2141.2001.02771.x[Crossref]
  • [17] Kapur D., Dorsky D., Feingold J. M., Bona R. D., Edwards R. L., Aslanzadeh J., et al., Incidence and outcome of vancomycin-resistant enterococcal bacteremia following autologous peripheral blood stem cell transplantation, Bone Marrow Transplant, 2000, 25, 147–152 http://dx.doi.org/10.1038/sj.bmt.1702123[Crossref]
  • [18] Durand M. L., Calderwood S. B., Weber D. J., Miller S. I., Southwick F. S., Caviness V. S., Jr., et al., Acute bacterial meningitis in adults. A review of 493 episodes, N Engl J Med, 1993, 328, 21–28 http://dx.doi.org/10.1056/NEJM199301073280104[Crossref]
  • [19] Stevenson K. B., Murray E. W., Sarubbi F. A., Enterococcal meningitis: report of four cases and review, Clin Infect Dis, 1994, 18, 233–239 http://dx.doi.org/10.1093/clinids/18.2.233[Crossref]
  • [20] Brown D. R., Reichman R. C., Enterococcal meningitis: a subacute presentation, N Y State J Med, 1989, 89, 92–93
  • [21] Huycke M. M., Sahm D. F., Gilmore M. S., Multipledrug resistant enterococci: the nature of the problem and an agenda for the future, Emerg Infect Dis, 1998, 4, 239–249 http://dx.doi.org/10.3201/eid0402.980211[Crossref]
  • [22] Wessels M. R., Streptococcal and enterococcal infections, In: Fauci A. S., Braunwald E., Kasper D. L., Hauser S. L., Longo D. L., Jameson J. L., et al., (Eds.), Harrison’s principles of internal medicine. 17th ed., McGraw-Hill, New York, 2008
  • [23] Levine D. P., Clinical experience with daptomycin: bacteraemia and endocarditis, J Antimicrob Chemother, 2008, 62 Suppl 3, iii35–39 [WoS]
  • [24] Koc Y., Snydman D. R., Schenkein D. S., Miller K. B., Vancomycin-resistant enterococcal infections in bone marrow transplant recipients, Bone Marrow Transplant, 1998, 22, 207–209 http://dx.doi.org/10.1038/sj.bmt.1701303[Crossref]

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