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2011 | 6 | 3 | 271-278

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Sentinel lymph node in colorectal cancer - 5 years follow up


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To assess the impact of micrometastases in sentinel and non-sentinel lymph nodes on long-term survival rates of patients treated for colorectal cancer (CRC). Data of 57 patients diagnosed with CRC and treated in the Department of Surgical Oncology in Gdansk in the years 2002–2006 were retrospectively analyzed. Clinico-histopathological data were analyzed using chi-square tests. The effect on long-time survival rates was analyzed using Kaplan-Meier survival probability estimates. Identification of the SLN was performed using the blue dye staining method. All regional lymph nodes were subject to standard histopathological examination. Additionally in 32(56.14%) patients whose nodes were found negative for metastases on standard staining further immunohistochemical analyses were performed. In the analyzed group SLNB was performed in 42(73.7%) patients with colon cancer and in 15(26.3%) with rectal cancer. Identification of the SLN was possible in 45(78.9%) patients. The sensitivity of SLNB was 33%. False negatives were found in 66%. SLNB is a feasible method in CRC patients. We presume that lack of micrometastases in the SLN and non-SLN cannot be regarded as a prognostic factor.










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1 - 6 - 2011
8 - 4 - 2011


  • Department of Surgical Oncology, Medical University of Gdansk, 80-952, Gdansk, Poland
  • Department of Surgical Oncology, Medical University of Gdansk, 80-952, Gdansk, Poland
  • Department of Surgical Oncology, Medical University of Gdansk, 80-952, Gdansk, Poland
  • Department of Pathology, Medical University of Gdansk, 80-952, Gdansk, Poland
  • Division of Propedeutics of Oncology, Medical University of Gdansk, 80-952, Gdansk, Poland
  • Department of Surgical Oncology, Medical University of Gdansk, 80-952, Gdansk, Poland


  • [1] Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. Ca-A Cancer Journal for Clinicians 2005; 55: 74–108 http://dx.doi.org/10.3322/canjclin.55.2.74[Crossref]
  • [2] Polish Cancer Registry. Cancer in Poland in 2006.
  • [3] Nakanishi Y, Ochiai A, Yamauchi Y, Moriya Y, Yoshimura K, Hirohashi S. Clinical implications of lymph node micrometastases in patients with colorectal cancers. A case control study. Oncology 1999; 57: 276–280 http://dx.doi.org/10.1159/000012060[Crossref]
  • [4] Gennari L, Doci R, Rossetti C. Prognostic factors in colorectal cancer. Hepatogastroenterology 2000; 47: 310–314
  • [5] Kehoe J, Khatri VP. Staging and prognosis of colon cancer. Surg Oncol Clin N Am 2006; 15: 129–146 http://dx.doi.org/10.1016/j.soc.2005.08.006[Crossref]
  • [6] Saha S, Wiese D, Badin J, Beutler T, Nora D, Ganatra BK, Desai D, Kaushal S, Nagaraju M, Arora M, Singh T. Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging. Annals of Surgical Oncology 2000;7: 120–124 http://dx.doi.org/10.1007/s10434-000-0120-z[Crossref]
  • [7] Saha S, Bilchik A, Wiese D, Espiniosa M, Badin J, Ganatra BK, Desai D, Kaushal S, Singh T, Arora M: Ultrastaging of colorectal cancer by sentinel lymph node mapping technique - A multicenter trial. Annals of Surgical Oncology 2001; 8: 94–98
  • [8] Blumberg D, Ramanathan RK. Treatment of colon and rectal cancer. J Clin Gastroenterol 2002; 34: 15–26 http://dx.doi.org/10.1097/00004836-200201000-00005[Crossref]
  • [9] Morton DL, Wen D-, Wong JH, Economou JS, Cagle LA, Storm FK: Technical details of intraoperative lymphatic mapping for early stage melanoma. Archives of Surgery 1992; 127: 392–399 [Crossref]
  • [10] Giuliano AE, Jones RC, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer. Journal of Clinical Oncology 1997; 15: 2345–2350
  • [11] Kusamo M, Tajima Y, Yamazaki K, Kato M, Watenabe M, Miwa M. Sentinel node mapping guided by indocyanina green fluorescence imaging: A new method for sentinel node navigation surgery in gastrointestinal cancer. Dig Surg 2008; 25: 103–108 http://dx.doi.org/10.1159/000121905[WoS][Crossref]
  • [12] Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin Jr. EW. Identification of occult micrometastases in pericolic lymph nodes of Dukes’ B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49: Correlation with long-term survival. Cancer 1994; 73: 563–569 http://dx.doi.org/10.1002/1097-0142(19940201)73:3<563::AID-CNCR2820730311>3.0.CO;2-D[Crossref]
  • [13] Hermanek P, Hutter RVP, Sobin LH, Wittekind C. Classification of isolated tumor cells and micrometastasis. Cancer 1999; 86: 2668–2673 http://dx.doi.org/10.1002/(SICI)1097-0142(19991215)86:12<2668::AID-CNCR11>3.0.CO;2-R[Crossref]
  • [14] Iddings D, Bilchik A. The biologic significance of micrometastatic disease and sentinel lymph node technology on colorectal cancer. J Surg Oncol 2007;96:671–667 http://dx.doi.org/10.1002/jso.20918[WoS][Crossref]
  • [15] Sobin L, Wittekind C. UICC (2002) TNM classification of malignant tumors. New York: Wiley&Sons, 2002
  • [16] Doekhie FS, Peeters KCMJ, Kuppen PJK, Mesker WE, Tanke HJ, Morreau H, van de Velde CJH, Tollenaar RAEM. The feasibility and reliability of sentinel node mapping in colorectal cancer. Eur J Surg Oncol 2005; 31: 854–862 http://dx.doi.org/10.1016/j.ejso.2005.05.011[Crossref]
  • [17] Cabanas RM. An approach for the treatment of penile carcinoma. Cancer 1977; 39: 456–466. http://dx.doi.org/10.1002/1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO;2-I[Crossref]
  • [18] Levenback C, Burke TW, Gershenson DM, Morris M, Malpica A, Ross MI. Intraoperative lymphatic mapping for vulvar cancer. Obstet Gynecol 1994; 84: 163–167
  • [19] Kelemen PR, Van Herle AJ, Giuliano AE. Sentinel lymphadenectomy in thyroid malignant neoplasms. Archives of Surgery 1998; 133: 288–292 http://dx.doi.org/10.1001/archsurg.133.3.288[Crossref]
  • [20] Bembenek A, Gretschel S, Ulmer C, Bayraktar S, Schlag PM. Sentinel node biopsy: Definition, historical development and methodology. Onkologe 2003; 9: 599–610 http://dx.doi.org/10.1007/s00761-003-0524-z[Crossref]
  • [21] Kitagawa Y, Fujii H, Mukai M, Kubota T, Ando N, Watanabe M, Ohgami M, Otani Y, Ozawa S, Hasegawa H, Furukawa T, Kumai K, Ikeda T, Nakahara T, Kubo A, Kitajima M. The role of the sentinel lymph node in gastrointestinal cancer. Surg Clin North Am 2000;80:1799–1809 http://dx.doi.org/10.1016/S0039-6109(05)70262-0[Crossref]
  • [22] Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, Hammond MEH, Henson DE, Hutter RVP, Nagle RB, Nielsen ML, Sargent DJ, Taylor CR, Welton M, Willett C. Prognostic factors in colorectal cancer: College of American Pathologists consensus statement 1999. Archives of Pathology and Laboratory Medicine 2000; 124: 979–994
  • [23] Esser S, Reilly WT, Riley LB, Eyvazzadeh C, Arcona S, Galandiuk S. The role of sentinel lymph node mapping in staging of colon and rectal cancer. Dis Colon Rectum 2001; 44: 850–856 http://dx.doi.org/10.1007/BF02234707[Crossref]
  • [24] Veronesi U, Galimberti V, Zurrida S, Pigatto F, Veronesi P, Robertson C, Paganelli G, Sciascia V, Viale G. Sentinel lymph node biopsy as an indicator for axillary dissection in early breast cancer. Eur J Cancer 2001; 37: 454–458 http://dx.doi.org/10.1016/S0959-8049(00)00410-X[Crossref]
  • [25] Weaver DL. Sentinel lymph nodes and breast carcinoma: Which micrometastases are clinically significant? Am J Surg Pathol 2003;27:842–845 http://dx.doi.org/10.1097/00000478-200306000-00018[Crossref]
  • [26] Bilchik AJ, Hoon DSB, Saha S, Turner RR, Wiese D, DiNone M, Koyanagi K, McCarter M, Shen P, Iddings D, Chen S, Gonzalez M, Elashoff D, Morton DL. Prognostic impact of micrometastases in colon cancer: Interim results of a prospective multicenter trial. Ann Surg 2007; 246: 568–575 http://dx.doi.org/10.1097/SLA.0b013e318155a9c7[Crossref]
  • [27] Wong JH, Steineman S, Calderia C, Bowles J, Namiki T. Ex vivo sentinel node mapping in carcinoma of the colon and rectum. Ann Surg 2001; 233: 515–521 http://dx.doi.org/10.1097/00000658-200104000-00006[Crossref]
  • [28] Bertagnolli M, Miedema B, Redston M, Dowell J, Niedzwiecki D, Fleshman J, Bem J, Mayer R, Zinner M, Comton C. Sentinel node staging of resectable colon cancer: Results of a multicenter study. Ann Surg 2004; 240: 624–630
  • [29] Patten LC, Berger DH, Rodriguez-Bigas M, Manfield P, Delpassand E, Cleary KR, Fagan SP, Curley SA, Hunt KK, Feg BW. A Prospective Evaluation of Radiocolloid and Immunohistochemical Staining in Colon Carcinoma Lymphatic Mapping. Cancer 2004; 100: 2104–2109 http://dx.doi.org/10.1002/cncr.20233[Crossref]
  • [30] Saha S, Monson KM, Bilchik A, Beutler T, Dan AG, Schochet E, Wiese D, Kaushal S, Ganatra B, Desai D. Comparative analysis of nodal upstaging between colon and rectal cancers by sentinel lymph node mapping: A prospective trial. Dis Colon Rectum 2004;47:1767–1772 http://dx.doi.org/10.1007/s10350-004-0661-5[Crossref]
  • [31] Paramo JC, Summerall J, Wilson C, Cabral A, Willis I, Wodnicki H, Poppiti R, Mesko TW. Intraoperative sentinel lymph node mapping in patients with colon cancer. Am J Surg 2001; 182: 40–43 http://dx.doi.org/10.1016/S0002-9610(01)00658-4[Crossref]
  • [32] Broderick-Villa G, Ko A, O’Connell TX, Guenther JM, Danial T, DiFronzo LA. Does tumor burden limit the accuracy of lymphatic mapping and sentinel lymph node biopsy in colorectal cancer? Cancer Journal 2002;8:445–450 http://dx.doi.org/10.1097/00130404-200211000-00008[Crossref]
  • [33] Joosten JJA, Strobbe LJA, Wauters CAP, Pruszczynski M, Wobbes T, Ruers TJM. Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinoma. Br J Surg 1999;86:482–486 http://dx.doi.org/10.1046/j.1365-2168.1999.01051.x[Crossref]
  • [34] Greene F. AJCC cancer staging manual. New York: Springer, 2002 http://dx.doi.org/10.1007/b97251[Crossref]
  • [35] Liberale G, Lasser P, Sabourin J, Malka D, Duvillard P, Ellas D, Bogie V, Goere D, Ducreux M, Pocard M. Sentinel lymph nodes of colorectal carcinoma: reappraisal of 123 cases. Gastroenterol Clin Biol 2007; 31: 281–285 http://dx.doi.org/10.1016/S0399-8320(07)89374-2[WoS]
  • [36] Broll R, Schauer V, Schimmelpenning H, Strick M, Woltmann A, Best R, Bruch HS, Duchrow M. Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas: An immunohistochemical study. Dis Colon Rectum 1997; 40:1465–1471 http://dx.doi.org/10.1007/BF02070713[Crossref]
  • [37] Liefers G-, Cleton-Jansen A-, Van De Velde CJH, Hermans JO, van Krieken JHJM, Cornelisse CJ, Tollenaar RAEM. Micrometastases and survival in stage II colorectal cancer. N Engl J Med 1998; 339: 223–228 http://dx.doi.org/10.1056/NEJM199807233390403[Crossref]
  • [38] Rosenberg R, Hoos A, Mueller J, Baier P, Stricker D, Werner M, Nekarda H, Siewert JR. Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of nodenegative colorectal cancer patients. Journal of Clinical Oncology 2002; 20: 1049–1055 http://dx.doi.org/10.1200/JCO.20.4.1049[Crossref]

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