Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

• Authors: Alin Ciobica , Veronica Bild , Lucian Hritcu , Manuela Padurariu , Walther Bild
• Languages of publication: EN

Abstracts

EN

In addition to its known classical roles, the renin angiotensin system (RAS) has more subtle functions which include the regulation of emotional responses. Previous studies regarding the anxiety related behavior of RAS have showed controversial results. There is also evidence that oxidative stress accompanies angiotensin II infusion, but the role of AT1/AT2 specific receptors is not clear. The aim of this study was to evaluate the effects of central angiotensin II receptor blockers on anxiety state and oxidative stress. Behavioral testing included elevated plus maze, while oxidative stress status was measured though the extent of a lipid peroxidation product (malondialdehyde-MDA) and the specific activity of some defense antioxidant enzymes (superoxide dismutase-SOD and glutathione peroxidase-GPx). The rats treated with angiotensin II spent significantly less time in the open-arms of elevated-plus-maze, while the administration of losartan resulted in a significant increase of this time. We observed a significant increase of MDA concentration in the angiotensin II group and a decrease of MDA levels in both losartan and PD-123177 groups. In addition, a significant correlation was seen between the time spent in the open arms and oxidative stress markers. These findings could lead to important therapeutic aspects regarding the use of angiotensin II receptor blockers in anxiety-related disorders.

Keywords

EN

Angiotensin II; Losartan; PD-123177; Anxiety; Oxidative stress

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 3
• Pages: 331-340

Dates

published

1 - 6 - 2011

online

8 - 4 - 2011

Contributors

author

Alin Ciobica

• Department of Biology, Alexandru Ioan Cuza University University, 700506, Iasi, Romania

author

Veronica Bild

author

Lucian Hritcu

• Department of Biology, Alexandru Ioan Cuza University University, 700506, Iasi, Romania

author

Manuela Padurariu

• GR. T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania

author

Walther Bild

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Identifiers

DOI

10.2478/s11536-011-0010-8