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2011 | 6 | 2 | 137-147

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RNA interference and its therapeutic potential


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RNA interference is a technique that has become popular in the past few years. This is a biological method to detect the activity of a specific gene within a cell. RNAi is the introduction of homologous double stranded RNA to specifically target a gene’s product resulting in null or hypomorphic phenotypes. This technique involves the degradation of specific mRNA by using small interfering RNA. Both microRNA (miRNA) and small interfering RNA (siRNA) are directly related to RNA interference. RNAi mechanism is being explored as a new technique for suppressing gene expression. It is an important issue in the treatment of various diseases. This review considers different aspects of RNAi technique including its history of discovery, molecular mechanism, gene expression study, advantages of this technique against previously used techniques, barrier associated with this technique, and its therapeutic application.











Physical description


1 - 4 - 2011
17 - 2 - 2011


  • Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, 2200, Denmark
  • School of Biological Sciences, Flinders University, Flinders, SA, 5042, Australia
  • System Biology Research Center, School of Life Sciences, University of Skövde, Box 408, SE-541 28, Skövde, Sweden


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