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Journal
2011 | 6 | 2 | 193-200
Article title

CSF and serum total-tau and phospho-tau(181P) in MS patients

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EN
Abstracts
EN
In search of biological marker in multiple sclerosis (MS), total-tau and phospho-tau (Thr181) concentrations were established in CSF and serum of 78 patients with MS, using commercially available kits. Serum and CSF concentrations of IgG, IgM, and albumin were assayed simultaneously to calculate quotients and indices of intrathecal synthesis. Serum t-tau detection was strikingly low (23.1%); therefore, this factor was excluded from further analysis. Serum p-tau levels did not correlate with any of indices or quotients. Unexpectedly, CSF t-tau and p-tau showed an inverse relation with MSSS and EDSS, which has not been published elsewhere. Our results do not support utility of serum t-tau and p-tau as surrogate markers for MS.
Publisher

Journal
Year
Volume
6
Issue
2
Pages
193-200
Physical description
Dates
published
1 - 4 - 2011
online
17 - 2 - 2011
Contributors
  • Department of Neurology, Medical University of Lublin, 20-954, Lublin, Poland, jjawor@onet.eu
author
  • 2nd Department of Anaesthesiology and Intensive Care, Medical University of Lublin, 20-081, Lublin, Poland
  • Department of Neurology, Medical University of Lublin, 20-954, Lublin, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0003-7
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