A short overview of vitamin C and selected cells of the immune system

• Authors: Voja Pavlovic , M. Sarac
• Languages of publication: EN

Abstracts

EN

Vitamin C (ascorbic acid) is an essential water-soluble nutrient that primarily exerts its effect on a host defense mechanisms and immune homeostasis and is the most important physiological antioxidant. Stable intake of vitamin C is essential for life in humans because the body does not synthesize it. Even the numerous studies have demonstrated that vitamin C supplementation stimulates the immune system, prevents DNA damage and significantly decreases the risk of a wide range of pathologies; the potential protective mechanisms are still largely unknown. This review summarizes the recently known facts about the role of vitamin C on the selected cells of the immune system and potential molecular mechanisms involved. Further, in this review, many new data about the positive effects of vitamin C on the immune system, potential toxicological effects, vitamin C supplementation in disease development, as well as some proposed mechanisms of vitamin C activity, are discussed.

Keywords

EN

Vitamin C; Immune system; T-cells; Neutrophils; Dendritic cells

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 1
• Pages: 1-10

Dates

published

1 - 2 - 2011

online

16 - 12 - 2010

Contributors

author

Voja Pavlovic

• Institute of Physiology, Medical Faculty, University in Nis, 18000, Nis, Serbia

author

M. Sarac

• Medical Faculty, University in Nis, 18000, Nis, Serbia

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Identifiers

DOI

10.2478/s11536-010-0066-x