Comparing hyoscine and drotaverine effects on colon in CT colonography

• Authors: Athanas Kristev , Nikolay Sirakov , Damianka Getova , Vasil Katcarov , Vladimir Sirakov , Rumen Stefanov , Valentin Turiiski , Kichka Velkova
• Languages of publication: EN

Abstracts

EN

Hyoscine and drotaverine effectiveness was compared for the purposes of achieving optimum distension following insufflation in CT colonography. The in vitro effects of hyoscine and drotaverine on tone and contractility of SM preparations isolated from different areas of human colon were studied by isometric registration of contractile activity. Both medications have a relaxing effect on SM preparations and inhibit their spontaneous contractions. The drotaverine-induced effects were reliably more marked than the hyoscine-induced ones. CT colonography was performed in 70 patients who were injected with equal doses of either hyoscine (n=32) or drotaverine (n=38). The degree of drug-induced distension in both groups was determined by measuring the lumen of the colon on a 2D reconstruction. In most colon areas the width of the distended lumen was greater in the drotaverine-treated patients. We concluded that drotaverine can be used as a means to facilitate colonic distension.

Keywords

EN

SM preparation; Hyoscine; Drotaverine; Human colon; CT colonography; Distension

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 2
• Pages: 234-242

Dates

published

1 - 4 - 2011

online

17 - 2 - 2011

Contributors

author

Athanas Kristev

• Departments of Biophysics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Nikolay Sirakov

• Image Diagnostics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Damianka Getova

• Pharmacology and Clinical Pharmacology Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Vasil Katcarov

• Departments of Biophysics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Vladimir Sirakov

• Image Diagnostics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Rumen Stefanov

• Social medicine and health management Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Valentin Turiiski

• Departments of Biophysics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

author

Kichka Velkova

• Image Diagnostics, Medical University — Plovdiv, 4002, Plovdiv, Bulgaria

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Identifiers

DOI

10.2478/s11536-010-0065-y