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Journal
2010 | 5 | 6 | 679-682
Article title

Intercellular adhesion molecule-1 gene polymorphisms in patients with familial mediterranean fever

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EN
Abstracts
EN
Familial Mediterranean fever (FMF) is a disease of unknown etiology characterized by recurrent attacks of polyserositis and fever. Intercellular adhesion molecule-1 (ICAM-1) is known to contribute inflammatory conditions by regulating leukocyte localization at inflammatory sites. The aim of this study was to evaluate the probable association of ICAM-1 G/R 241 and ICAM-1 E/K 469 polymorphisms according to susceptibility with FMF. Sixty-seven FMF patients and 83 healthy volunteers were included in the study. Genomic DNA was extracted from EDTA-preserved whole blood of whole series of patients and controls, and genotyped by polymerase chain reaction (PCR) and allele-specific oligonucleotide techniques for ICAM-1 polymorphisms G/R at codon 241 and E/K at codon 469. The ICAM-1 241 genotype and allele frequencies of FMF patients and healthy volunteers were similar. The frequency of ICAM-1 K469 homozygosity was significantly lower in FMF patients than in the controls (32.8% vs 50.7% subsequently, p=0.03). Moreover, ICAM-1 E469 allele was more frequent in FMF patients than in controls (44.8% vs 32.3%, p:0.03). Our results showed that ICAM-1 469 gene polymorphism could contribute to the pathogenesis of FMF.
Publisher
Journal
Year
Volume
5
Issue
6
Pages
679-682
Physical description
Dates
published
1 - 12 - 2010
online
7 - 10 - 2010
References
  • [1] Direskeneli H, Ozdogan H, Korkmaz C, Akoglu T, Yazici H., Serum soluble intercellular adhesion molecule-1 and interleukine-8 levels in familial Mediterranean fever, J Rheumatol., 1999, 26,1983–1986
  • [2] Yang H, Vora DK, Targan SR, Toyoda H, Beaudet AL, Rotter JI., Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease, Gastroenterology., 1995,109, 440–448 http://dx.doi.org/10.1016/0016-5085(95)90331-3[Crossref]
  • [3] Mycko MP, Kwinkowski M, Tronczynska E, Szymanska B, Selmaj KW., Multiple sclerosis: the increased frequency of the ICAM-1 exon 6 gene point mutation genetic type K469, Ann Neurol., 1998, 44, 70–75 http://dx.doi.org/10.1002/ana.410440113[Crossref]
  • [4] McLaren AJ, Marshall SE, Haldar NA, Millighan CG, Fuggle SV, Morris PJ, et al. Adhesion molecule polymorphisms in chronic renal allograft failure, Kidney Int., 1999, 55, 1977–1982 http://dx.doi.org/10.1046/j.1523-1755.1999.00427.x[Crossref]
  • [5] Verity DH, Vaughan RW, Kondeatis E, Madanat W, Zureikat H, Fayyad F, et al. Intercellular adhesion molecule-1 gene polymorphisms in Behcet’s disease, Eur J Immunogenet., 2000, 27, 73–76 http://dx.doi.org/10.1046/j.1365-2370.2000.00202.x[Crossref]
  • [6] Lee E.B, Kim J.Y, Kim E.H, Nam J.H, Park K.S, Song Y.W., Intercellular adhesion molecule-1 polymorphisms in Korean patients with rheumatoid arthritis, Tissue Antigens., 2004, 64, 473–477 http://dx.doi.org/10.1111/j.1399-0039.2004.00285.x[Crossref]
  • [7] Kim EH, Mok JW, Bang DS, Lee ES, Park KS, Lee SN., Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behçet’s disease, J Korean Med Sci., 2003,18, 415–418 http://dx.doi.org/10.3346/jkms.2003.18.4.483[Crossref]
  • [8] Livneh A, Langevitz P, Zemer D., Zaks N, Kees S, Lidar T. et al., Criteria for the diagnosis of familial Mediterranean fever, Arthritis Rheum., 1997, 40, 1879–1885 http://dx.doi.org/10.1002/art.1780401023[Crossref]
  • [9] Amoli MM, Shelley E, Mattey DL, Garcia-Porrua C, Thomson W, Hajeer AH et al., Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis, J Rheumatol., 2001, 28, 1600–1604
  • [10] Joling P, Boom S, Johnson J., Dekker ME, van den Tweel JG, Schuurman HJ et al., Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion B-cells and follicular dendritic cells, Adv Exp Med Biol., 1994, 355,135
  • [11] Vora DK, Rosenbloom CL, Beaudet AL, Cottingham RW., Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster, Genomics., 1994, 21, 477 http://dx.doi.org/10.1006/geno.1994.1303[Crossref]
  • [12] Gaetani E, Flex A, Pola R, Papaleo P, De Martini D, Pola E. et al., The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease, Blood Coagul Fibrinolysis., 2002 Sep,13(6), 483–488 http://dx.doi.org/10.1097/00001721-200209000-00002[Crossref]
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0037-2
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