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Journal
2010 | 5 | 2 | 194-197
Article title

Fluconazole, caspofungin, voriconazole in combination with amphotericin B

Content
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Languages of publication
EN
Abstracts
EN
Combined antifungal therapy has been suggested to enhance the efficacy and reduce the toxicity of antifungal agents. The aim of the study was to investigate the in vitro synergistic activity of caspofungin, voriconazole, and fluconazole with amphotericin B against ten isolates of Candida parapsilosis and Candida albicans strains which were resistant to azoles or amphotericin B. Three different antifungal combinations (amphotericin B [AP] - caspofungin [CS], amphotericin B - fluconazole [FL], and AP - voriconazole [VO]) were evaluated for in vitro synergistic effect by the microdilution checkerboard and E-test methods. For the majority of strains, the combination test showed indifferent activity. Via the E-test method, synergistic activity was seen in 3 strains in response to AP-CS combination treatment and in one strain after administration of AP-FL; however, no synergy was observed in response to combination treatment with P-VO. Antagonistic activity was the result in 1 strain treated with AP-CS as well as in 6 strains treated with AP-FL and AP-VO combinations. Via the microdilution test, no synergistic activity was seen after treatment with all 3 combinations. Antagonistic activity was the result in 2 strains with AP-CS, in 6 strains with AP-VO and in 5 strains with AP-FL combinations. Agreement between the checkerboard and E-test methods was observed to be approximately 72%. These combinations may be used in the case of antifungal resistance.
Keywords
Publisher

Journal
Year
Volume
5
Issue
2
Pages
194-197
Physical description
Dates
published
1 - 4 - 2010
online
17 - 4 - 2010
Contributors
author
  • Department of Microbiology, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey, kalkanci@gazi.edu.tr
author
  • Department of Infectious Diseases, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
author
  • Department of Infectious Diseases, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
author
  • Department of Microbiology, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
author
  • Department of Microbiology, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
author
  • Department of Infectious Diseases, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
  • Department of Infectious Diseases, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0010-0
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