Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2010 | 5 | 3 | 292-297

Article title

An unusual cause of hypotension and abnormal electrocardiogram (ECG) - scombroid poisoning



Title variants

Languages of publication



Scombroid fish or histamine food poisoning is an illness typically associated with fish consumption, rarely encountered and reported in Europe. Symptoms develop quickly and resemble an allergic reaction. This paper reports three cases of severe scombroid poisoning in previously healthy patients, which presented diffuse macular erythema, hypotension, palpitations, and abnormal electrocardiogram (ECG). All patients required intensive care, with a complete resolution of symptoms and ECG changes within 24 hours. This is the first Romanian report of scombroid poisoning, emphasizing that medical personnel should be aware of this condition, because symptoms and ECG changes often lead to confusion with other diseases.










Physical description


1 - 6 - 2010
9 - 4 - 2010


  • [1] Borade P.S., Ballary C.C., Lee D.K.C., A fishy cause of sudden near fatal hypotension, Resuscitation, 2007, 72, 158–160 http://dx.doi.org/10.1016/j.resuscitation.2006.05.021[WoS][Crossref]
  • [2] Kow-Tong C., Maison M.D., Outbreak of scombroid fish poisoning, Taiwan, Am J Public Heath, 1987, 77, 1335–1336 http://dx.doi.org/10.2105/AJPH.77.10.1335[Crossref]
  • [3] Harrison H., Bates N., Scombroid, In: Brent J., Wallace K.L., Burkhart K.K., Phillips S.D., Donovan J.W. (Eds.), Critical Care Toxicology. Diagnosis and management of the critically poisoned patient, Elsevier Mosby, Philadelphia, PA, 2005 [Crossref]
  • [4] Lipp E.K., Rose J.B., The role of seafood in foodborne diseases in the United States of America, Rev Sci Technol, 1997, 16, 620–640
  • [5] Predy G., Honish L., Hohn W., Jones S., Was it something she ate? Case report and discussion of scombroid poisoning, CMAJ, 2003, 168: 587–588
  • [6] Chegini S., Metcalfe D.D., Contemporary issues in food allergy: seafood toxin-induced disease in the differential diagnosis of allergic reactions, Allergy Asthma Proc, 2005, 26, 183–190 [PubMed]
  • [7] Ascione A., Barresi L.S., Sarullo F.M., De Silvestre G., Two cases of “scombroid syndrome” with severe cardiovascular compromise, Cardiologia, 1997, 42, 1285–1288, (in Italian) [PubMed]
  • [8] Sobel J., Painter J., Illnesses caused by marine toxins, Clin Infect Dis, 2005, 41, 1290–1296 http://dx.doi.org/10.1086/496926[Crossref]
  • [9] Tursi A., Modeo M.E., Cascella A.M., Cuccorese G., Spinazzola A.M., Miglietta A., Scombroid syndrome with severe and prolonged cardiovascular involvement, Recenti Prog Med, 2001, 92, 537–539 [PubMed]
  • [10] Lavon O., Lurie Y., Bentur Y., Scombroid fish poisoning in Israel, 2005–2007, IMAJ, 2008, 10, 789–792
  • [11] Al Bulushi I., Poole S., Deeth H.C., Dykes G.A., Biogenic amines in fish: roles in intoxication, spoilage, and nitrosamine formation-a review, Crit Rev Food Sci Nutr, 2009, 49, 369–377 http://dx.doi.org/10.1080/10408390802067514[WoS][Crossref]
  • [12] Simons F.E., H1-antihistamines: more relevant than ever in the treatment of allergic disorders, J Allergy Clin Immunol, 2003, 112, 542–552 http://dx.doi.org/10.1016/S0091-6749(03)01876-1[Crossref]
  • [13] Gikas A., Lazaros G., Kontou-Fili K., Acute ST-segment elevation myocardial infarction after amoxycillin-induced anaphylactic shock in a young adult with normal coronary arteries: a case report, BMC Cardiovasc Disord, 2005, 5, 6, DOI: 10.1186/1471-2261-5-6 http://dx.doi.org/10.1186/1471-2261-5-6[Crossref]
  • [14] Gupta K.M., Gupta P., Rezai F., Histamine - Can it cause an acute coronary event?, Clin Cardiol, 2001, 24, 258–259 http://dx.doi.org/10.1002/clc.4960240317[Crossref]
  • [15] Vigorito C., Giordano A., De Caprio L., Vitale D.F., Maurea N., Silvestri P., Tuccillo B., Ferrara N., Marone G., Rengo F., Effects of histamine on coronary hemaodynamics in humans: role of H1 and H2 receptors, J Am Coll Cardiol, 1987, 10, 1207–1213 http://dx.doi.org/10.1016/S0735-1097(87)80120-1[Crossref]
  • [16] Sakata Y., Komamura K., Hirayama A., Nanto S., Kitakaze M., Hori M., Elevation of the plasma histamine concentration in the coronary circulation in patients with variant angina, Am J Cardiol, 1996, 77, 1121–1126 http://dx.doi.org/10.1016/S0002-9149(96)00147-6[Crossref]
  • [17] Sinkiewicz W., Sobański P., Bartuzi Z., Allergic myocardial infarction, Cardiol J. 2008, 15, 220–225
  • [18] Levi R., Zavecz J.H., Ovary Z., IgE-mediated cardiac hypersensitivity reactions. An experimental model, Int Arch Allergy Appl Immunol, 1978, 57, 529–534 http://dx.doi.org/10.1159/000232148[Crossref]
  • [19] Becker K., Southwick K., Reardon J., Berg R., MacCormack J.N., Histamine Poisoning Associated With Eating Tuna Burgers, JAMA, 2001, 285,1327–1330 http://dx.doi.org/10.1001/jama.285.10.1327[Crossref]
  • [20] Bédry R., Gabinski C., Paty M.C., Diagnosis of scombroid poisoning by measurement of plasma histamine, N Engl J Med, 2000, 342, 520–521 http://dx.doi.org/10.1056/NEJM200002173420718[Crossref]
  • [21] Grinda J.M., Bellenfant F., Brivet F.G., Carel Y., Deloche A., Biventricular assist device for scombroid poisoning with refractory myocardial dysfunction: a bridge to recovery, Crit Care Med, 2004, 32, 1957–1959 http://dx.doi.org/10.1097/01.CCM.0000139921.38352.3D[Crossref]
  • [22] Singh V.N., Sharma R.K., Accelerated idioventricular rhythm, 2009, http://emedicine.medscape.com/article/150074-overview
  • [23] Thygesen K., Alpert J.S., White H.D., Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction, Eur Heart J, 2007, 28, 2525–2538 http://dx.doi.org/10.1093/eurheartj/ehm355[Crossref]
  • [24] Van de Werf F., Bax J., Betriu A., Blomstrom-Lundqvist C., Crea F., Falk V., et al., Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation, Eur Heart J, 2008, 29, 2909–2945 http://dx.doi.org/10.1093/eurheartj/ehn416[Crossref]
  • [25] Engrav M.B., Zimmerman M., Electrocardiographic changes associated with anaphylaxis in a patient with normal coronary arteries, West J Med, 1994, 161, 602–604
  • [26] Zavras G.M., Papadaki P.J., Kokkinis C.E., Kalokairinov K., Kouni S.N., Batsolaki M., Kounis syndrome secondary to allergic reaction following shellfish ingestion, Int J Clin Pract, 2003, 57, 622–624
  • [27] Lopez-Minguez J.R., Gonzalez Fernandez R., Millan Nunez V., Merchan Herrera. A., Altozano Gomez J.C., Garcia-Andoain J.M., Acute myocardial infarction secondary to anaphylactic reaction following shellfish ingestion. The need for rescue coronary angioplasty, Rev Esp Cardiol, 2000, 53, 1663–1666
  • [28] Shaver K.J., Adams C., Weiss S.J., Acute myocardial infarction after administration of lowdose intravenous epinephrine for anaphylaxis, Can J Emerg Med, 2006, 8, 289–294

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.