Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2010 | 5 | 3 | 375-380

Article title

Fluoride bioavailability in saliva using DENTTABS® compared to dentifrice


Title variants

Languages of publication



It was the aim of this study to assess fluoride retained in saliva after use of fluoride-containing tablet DENTTABS® compared to toothpaste containing amine fluoride. Four subjects (2 normal saliva secretors, 1 slow secretor, and 1 fast secretor) participated in this crossover study comparing DENTTABS® and ELMEX®. After baseline sample collection, calibrated study personnel brushed the subjects’ teeth with the assigned product for 3 minutes. Saliva samples were taken at baseline (T0), immediately after brushing (T1) and then 10 (T2), 25 (T3) and 85 (T4) minutes post-brushing. The amount of saliva collected was measured, and the fluoride content was analysed. All 4 subjects repeated all study cycles 5 times. Statistical analysis was done using the Mann-Whitney-U test and Spearman correlation. The fluoride retention was significantly higher after brushing with DENTTABS® at T1 and T2. There was a correlation between individual salivary flow rate and the F- content. Flow rate in g/min ranged from 1.1 to 3.8 at T1 and from 0.2 to 1.1 at T4 with much higher F- retention in slow secreting cycles. The saliva fluoride clearance kinetics of two equal amounts of fluoride-containing oral hygiene products demonstrate higher retention for DENTTABS®.










Physical description


1 - 6 - 2010
9 - 4 - 2010


  • Faculty of Dental Medicine, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448, Witten, Germany
  • Faculty of Dental Medicine, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448, Witten, Germany
  • Faculty of Dental Medicine, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448, Witten, Germany


  • [1] Dawes, C., Weatherell, J. A., Kinetics of fluoride in the oral fluids. J. Dent. Res., 1990, 69 Spec No, 638–644; discussion 682–633
  • [2] Featherstone, J. D., The science and practice of caries prevention. J. Am. Dent. Assoc., 2000, 131, 887–899 [Crossref]
  • [3] Margolis, H. C., Moreno, E. C., Physicochemical perspectives on the cariostatic mechanisms of systemic and topical fluorides. J. Dent. Res., 1990, 69 Spec No, 606–613; discussion 634–606
  • [4] Bruun, C., Givskov, H., Thylstrup, A., Whole saliva fluoride after toothbrushing with NaF and MFP dentifrices with different F concentrations. Caries Res., 1984, 18, 282–288 http://dx.doi.org/10.1159/000260778[Crossref]
  • [5] Aasenden, R., Brudevold, F., Richardson, B., Clearance of fluoride from the mouth after topical treatment or the use of a fluoride mouthrinse. Arch. Oral Biol., 1968, 13, 625–636 http://dx.doi.org/10.1016/0003-9969(68)90141-6[Crossref]
  • [6] Bijella, M. F., Brighenti, F. L., Buzalaf, M. A., Fluoride kinetics in saliva after the use of a fluoride-containing chewing gum. Braz. Oral Res., 2005, 19, 256–260 http://dx.doi.org/10.1590/S1806-83242005000400004[Crossref]
  • [7] Oliveby, A., Ekstrand, J., Lagerlof, F., Effect of salivary flow rate on salivary fluoride clearance after use of a fluoride-containing chewing gum. Caries Res., 1987, 21, 393–401 http://dx.doi.org/10.1159/000261045[Crossref]
  • [8] Hedman, J., Sjoman, R., Sjostrom, I., Twetman, S., Fluoride concentration in saliva after consumption of a dinner meal prepared with fluoridated salt. Caries Res., 2006, 40, 158–162 http://dx.doi.org/10.1159/000091064[Crossref]
  • [9] Sjogren, K., Birkhed, D., Persson, L. G., Noren, J. G., Salivary fluoride clearance after a single intake of fluoride tablets and chewing gums in children, adults, and dry mouth patients. Scand. J. Dent. Res., 1993, 101, 274–278
  • [10] Petersson, L. G., Arvidsson, I., Lynch, E., Engstrom, K., Twetman, S., Fluoride concentrations in saliva and dental plaque in young children after intake of fluoridated milk. Caries Res., 2002, 36, 40–43 http://dx.doi.org/10.1159/000057589[Crossref]
  • [11] Böshagen, C., Eifler, H., Gängler, P., Klinische Bewertung der Mundhygieneeffektivität einer Zahnputztablette. Zahnarzt und Praxis, 2005, 8, 420–424
  • [12] Schipper, R. G., Silletti, E., Vingerhoeds, M. H., Saliva as research material: biochemical, physicochemical and practical aspects. Arch. Oral Biol., 2007, 52, 1114–1135 http://dx.doi.org/10.1016/j.archoralbio.2007.06.009[WoS][Crossref]
  • [13] Newbrun, E., Topical fluorides in caries prevention and management: a North American perspective. J. Dent. Educ., 2001, 65, 1078–1083
  • [14] de Almeida Pdel, V., Gregio, A. M., Machado, M. A., de Lima, A. A., Azevedo, L. R., Saliva composition and functions: a comprehensive review. J. Contemp. Dent. Pract., 2008, 9, 72–80
  • [15] Jenkins, G. N., Saliva, in The Physiology and biochemistry of the Mouth., Jenkins, G. N., Editor. Blackwell Scientific Publications, Oxford, London, Edinburgh, 1978
  • [16] Heijnsbroek, M., Gerardu, V. A., Buijs, M. J., van Loveren, C., ten Cate, J. M., Timmerman, M. F., et al., Increased salivary fluoride concentrations after post-brush fluoride rinsing not reflected in dental plaque. Caries Res., 2006, 40, 444–448 http://dx.doi.org/10.1159/000094292[Crossref]
  • [17] Ten Cate, J. M., Buijs, M. J., Miller, C. C., Exterkate, R. A., Elevated fluoride products enhance remineralization of advanced enamel lesions. J. Dent. Res., 2008, 87, 943–947 http://dx.doi.org/10.1177/154405910808701019[Crossref][WoS]
  • [18] Duckworth, R. M., Morgan, S. N., Oral fluoride retention after use of fluoride dentifrices. Caries Res., 1991, 25, 123–129 http://dx.doi.org/10.1159/000261354[Crossref]
  • [19] Duckworth, R. M., Stewart, D., Effect of mouthwashes of variable NaF concentration but constant NaF content on oral fluoride retention. Caries Res., 1994, 28, 43–47 http://dx.doi.org/10.1159/000261619[Crossref]
  • [20] Duckworth, R. M., Knoop, D. T., Stephen, K. W., Effect of mouthrinsing after toothbrushing with a fluoride dentifrice on human salivary fluoride levels. Caries Res., 1991, 25, 287–291 http://dx.doi.org/10.1159/000261378[Crossref]
  • [21] Issa, A. I., Toumba, K. J., Oral fluoride retention in saliva following toothbrushing with child and adult dentifrices with and without water rinsing. Caries Res., 2004, 38, 15–19 http://dx.doi.org/10.1159/000073915[Crossref]
  • [22] Attin, T., Hellwig, E., Salivary fluoride content after toothbrushing with a sodium fluoride and an amine fluoride dentifrice followed by different mouthrinsing procedures. J. Clin. Dent., 1996, 7, 6–8

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.