“Does chronic kidney disease define a particular risk pattern of cerebral vessels modifications in patients with symptomatic ischemic cerebrovascular disease?”

• Authors: Ligia Petrica , Maxim Petrica , Gluhovschi Gheorghe , Matcau Liviu , Gadalean Florica , Ursoniu Sorin , Jianu Catalin , Velciov Silvia , Bob Flaviu , Gluhovschi Cristina , Trandafirescu Virginia , Matcau Diana , Bozdog Gheorghe , Muresan Carmina
• Languages of publication: EN

Abstracts

EN

Cardiovascular complications, including stroke, may be attributed the highest rate of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of our study was to evaluate the prevalence of CKD in patients with symptomatic ischaemic cerebrovascular disease and to establish of whether CKD may define a particular risk pattern of cerebral vessels modifications in this category of patients. The prevalence of CKD was evaluated in 590 consecutive patients with symptomatic ischaemic cerebrovascular disease admitted to a department of neurology. The types of stroke, the vascular territories, the vascular modifications and the haemodynamic changes (resistance index- RI) found by neurosonology (extracranial and transcranial Doppler ultrasound) were analysed in relation to classic and non-classic cerebrovascular risk factors, as well as to stages of CKD (defined by estimated glomerular filtration rate-eGFR-MDRD4 formula-K/DOQI 2002). The prevalence of CKD in the studied patients was 70.84%. Atherosclerosis in a diffuse pattern was detected in 79.7% of CKD patients, while carotid artery stenoses were found in 10% of cases, occlusions- 5.3%, stenoses + occlusions-1.2%, and multiple stenoses- 3.8% of cases. The RI evaluated in the internal carotid arteries correlated with fibrinogen(P<0.0001) and GFR(P<0.0001), while IR in the middle cerebral arteries correlated with fibrinogen(P<0.05), C-reactive protein(P<0.0001), and GFR(P<0.0001). There is a strong relation between symptomatic cerebrovascular disease and CKD, a fact demonstrated by the increased prevalence of CKD in these patients and by the severity of the cerebral vessels lesions.

Keywords

EN

Cerebrovascular disease; Chronic kidney disease; Extracranial Doppler ultrasound; Risk factors; Transcranial Doppler ultrasound

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 3
• Pages: 329-337

Dates

published

1 - 6 - 2010

online

9 - 4 - 2010

Contributors

author

Ligia Petrica

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Maxim Petrica

• County Emergency Hospital, Department of Neurology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Gluhovschi Gheorghe

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Matcau Liviu

• County Emergency Hospital, Department of Neurology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Gadalean Florica

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Ursoniu Sorin

• Department of Public Health Medicine, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Jianu Catalin

• County Emergency Hospital, Department of Neurology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Velciov Silvia

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Bob Flaviu

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Gluhovschi Cristina

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Trandafirescu Virginia

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Matcau Diana

• County Emergency Hospital, Department of Neurology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Bozdog Gheorghe

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

author

Muresan Carmina

• County Emergency Hospital, Department of Nephrology, ‘Victor Babes’ University of Medicine and Pharmacy, 300041, Timisoara, Romania

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Identifiers

DOI

10.2478/s11536-009-0131-5