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Journal

2010 | 5 | 1 | 83-90

Article title

Impact of pharmaceutical dosage form on stability and dissolution of roxithromycin

Content

Title variants

Languages of publication

EN

Abstracts

EN
The behavior of dispersible tablets containing enteric-coated pellets and oral suspension, both containing roxithromycin, was investigated using dissolution tests in different media. The dissolution test was performed under different pH conditions. For both dosage forms investigated, the test was conducted at pH 1.2, 4.5, and 6.8. Additionally, for dispersible tablets, the test involving increasing pH was performed at pH 1.2 (acid stage) and afterwards at pH 6.8 (buffer stage). The extent of dissolution was measured using high-performance liquid chromatography (HPLC). In all cases tested, roxithromycin underwent rapid degradation at pH 1.2. Dispersible tablets displayed the features of modified release preparations with a non-complete dissolution during the test times in all media. Conversely, the oral suspension behaved as an immediate release preparation, with degradation at pH 1.2. However, the dissolution of the oral suspension at pH 4.5 and 6.8 was rapid and complete. The role of enteric-coated pellets is to mask the bitter taste of the active substance upon administration. However, the coating showed lack of resistance to media at pH 1.2. Therefore, dispersible tablets containing enteric-coated pellets are not pharmaceutically equivalent to the immediate-release oral suspension.

Publisher

Journal

Year

Volume

5

Issue

1

Pages

83-90

Physical description

Dates

published
1 - 2 - 2010
online
29 - 1 - 2010

Contributors

  • R&D Department, Polfa Tarchomin SA, Fleminga 2, 03-176, Warszawa, Poland
author
  • R&D Department, Polfa Tarchomin SA, Fleminga 2, 03-176, Warszawa, Poland
  • Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Hallera 107, 80-416, Gdańsk, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-009-0113-7
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