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Journal
2010 | 5 | 5 | 541-543
Article title

Intracranial plasmacytoma as an initial presentation of multiple myeloma

Content
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Languages of publication
EN
Abstracts
EN
Intra-cranial involvement is an uncommon complication of multiple myeloma. We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple myeloma subsequent to initial intrcranial involvement is confined to exceptional cases. Despite aggressive systemic treatments, including autologous stem cell transplantation and local treatments such as cerebral radiotherapy, the prognosis for patients with CNS myeloma is extremely poor. Our unique case implies that physicians should be alert in case of vertigo or headache in cases with acute renal failure.
Publisher

Journal
Year
Volume
5
Issue
5
Pages
541-543
Physical description
Dates
published
1 - 10 - 2010
online
20 - 8 - 2010
Contributors
author
  • Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey, aleverikci@yahoo.com
author
  • Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Oncology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Pathology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Radiology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
References
  • [1] Fassas ABT, Muwalla F, Berryman T, Berryman T, Benramdane R, Joseph, L et al. Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and extra-medullary manifestations. Br J Haematol 2002;117;103–108 http://dx.doi.org/10.1046/j.1365-2141.2002.03401.x[Crossref]
  • [2] Petersen S, Wagner A, Gimsing P. Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature. Am J Hematol 1999;62; 228–233 http://dx.doi.org/10.1002/(SICI)1096-8652(199912)62:4<228::AID-AJH5>3.0.CO;2-3[Crossref]
  • [3] Nieuwenhuizen L, Biesma DH. Central nervous system myelomatosis: review of the literature. Eur J Haematol. 2008;80; 1–9 [PubMed]
  • [4] Kaplan JG, DeSouza TG, Farkash A, Shafran B, Pack D, Rehman F, Fuks J, Portenoy R. Leptomeningeal metastases: comparison of clinical features and laboratory data of solid tumors, lymphomas, and leukemias. J Neurooncol 1990;9; 225–229 http://dx.doi.org/10.1007/BF02341153[Crossref]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0104-8
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