Intracranial plasmacytoma as an initial presentation of multiple myeloma

• Authors: Alev Erikci , Ozkan Sayan , Bulent Karagoz , Zafer Kucukodaci , Murat Velioglu
• Languages of publication: EN

Abstracts

EN

Intra-cranial involvement is an uncommon complication of multiple myeloma. We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple myeloma subsequent to initial intrcranial involvement is confined to exceptional cases. Despite aggressive systemic treatments, including autologous stem cell transplantation and local treatments such as cerebral radiotherapy, the prognosis for patients with CNS myeloma is extremely poor. Our unique case implies that physicians should be alert in case of vertigo or headache in cases with acute renal failure.

Keywords

EN

Cranial involvement; Multiple myeloma; Vertigo; Headache

• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 5
• Pages: 541-543

Dates

published

1 - 10 - 2010

online

20 - 8 - 2010

Contributors

author

Alev Erikci

• Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey,

author

Ozkan Sayan

• Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey

author

Bulent Karagoz

• Departments of Oncology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey

author

Zafer Kucukodaci

• Departments of Pathology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey

author

Murat Velioglu

• Departments of Radiology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey

References

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• [2] Petersen S, Wagner A, Gimsing P. Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature. Am J Hematol 1999;62; 228–233 http://dx.doi.org/10.1002/(SICI)1096-8652(199912)62:4<228::AID-AJH5>3.0.CO;2-3[Crossref]
• [3] Nieuwenhuizen L, Biesma DH. Central nervous system myelomatosis: review of the literature. Eur J Haematol. 2008;80; 1–9 [PubMed]
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Identifiers

DOI

10.2478/s11536-009-0104-8