Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

• Authors: Kamile Gul , Ihsan Ustun , Yusuf Aydin , Dilek Berker , Halil Erol , Mustafa Unal , Ayse Barazi , Tuncay Delibasi , Serdar Guler
• Languages of publication: EN

Abstracts

EN

The aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

Keywords

EN

Thyroid Autoantibodies; Anti GAD; Type 1 Diabetes Mellitus

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2009
• Volume: 4
• Issue: 4
• Pages: 415-422

Dates

published

1 - 12 - 2009

online

3 - 10 - 2009

Contributors

author

Kamile Gul

• Department of Endocrinology and Metabolism, Ankara Ataturk Education and Research Hospital, 6533, Ankara, Turkey

author

Ihsan Ustun

• Department of Endocrinology, Mersin State Hospital, 33050, Mersin, Turkey

author

Yusuf Aydin

• Department of Endocrinology and Metabolism, Ankara Numune Training and Research Hospital, 6100, Ankara, Turkey

author

Dilek Berker

• Department of Endocrinology and Metabolism, Ankara Numune Training and Research Hospital, 6100, Ankara, Turkey

author

Halil Erol

• Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, 33156, USA

author

Mustafa Unal

• Department of Endocrinology, Afyon State Hospital, 03030, Afyon, Turkey

author

Ayse Barazi

• Department of Biochemistry, Ankara Numune Training and Research Hospital, 6100, Ankara, Turkey

author

Tuncay Delibasi

• Department of Endocrinology and Metabolism, Ankara Numune Training and Research Hospital, 6100, Ankara, Turkey

author

Serdar Guler

• Department of Endocrinology and Metabolism, Ankara Numune Training and Research Hospital, 6100, Ankara, Turkey

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Identifiers

DOI

10.2478/s11536-009-0080-z