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Journal
2009 | 4 | 4 | 423-427
Article title

Effects of an EE/CA compared with EE/CA-metformin on serum ADMA levels in women with polycystic ovary syndrome

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EN
Abstracts
EN
To determine the effects of EE/CA (Ethinylestradiol/ Cyproterone Acetate) and EE/CA-metformin treatments on the asymmetric dimethylarginine (ADMA) levels in women with PCOS (Polycystic Ovary Syndrome). Among 43 patients diagnosed with PCOS, one study arm (n=22) was administered (35 µg EE, 2mg CA) and the other (n=21) was administered (35 µg EE, 2mg CA plus 1700mg metformin). Serum ADMA, lipid profile, androgens, insulin, and HOMA-IR (Homeostatic Model Assessment of Insulin Resistance ) values were assessed prior to treatment and after 3 months of therapy. A significant reduction in ADMA levels relative to pre-treatment in the EE/CA+metformin group (1.2±0.4 vs 0.95±0.4, p=0.016) compared to the EE/CA group (1.0±0.5 vs 1.03±0.4, p >0.05). Andogens, insulin and HOMA-IR levels decreased in both treatment groups. All lipid profiles significantly improved in-group EE/CA+metformin while no significant decrease was observed in TG and HDL-cholesterol levels in EE/CA group. Post-treatment levels of HDL-C levels correlated significantly with the reducing ADMA levels in the EE/CA+metformin group (P=0.005, r= 0.602). Adding metformin to EE/CA therapy in PCOS may beneficial endothelium effects associated with reduction of ADMA levels.
Publisher

Journal
Year
Volume
4
Issue
4
Pages
423-427
Physical description
Dates
published
1 - 12 - 2009
online
3 - 10 - 2009
Contributors
  • Department of Internal Medicine, (Endocrinologist), Bozyaka Training and Research Hospital, 35380, Izmir, Turkey, leventkebapcilar@yahoo.com
author
  • Department of Internal Medicine, Bozyaka Training and Research Hospital, 35380, Izmir, Turkey
author
  • Department of Biochemistry, Bozyaka Training and Research Hospital, 35380, Izmir, Turkey
author
  • Department of Obstetrics and Gynecology, Aegean Obstetrics and Gynecology Teaching Hospital, 35120, Izmir, Turkey
  • Department of Obstetrics and Gynecology, Aegean Obstetrics and Gynecology Teaching Hospital, 35120, Izmir, Turkey
author
  • Department of Internal Medicine, Bozyaka Training and Research Hospital, 35380, Izmir, Turkey
  • Department of Internal Medicine, Bozyaka Training and Research Hospital, 35380, Izmir, Turkey
author
  • Department of Internal Medicine, Bozyaka Training and Research Hospital, 35380, Izmir, Turkey
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0074-x
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