Coronary artery disease associated with radiation therapy

• Authors: Turgay Celık , Cagdas Yuksel , Sait Demırkol , Atila Iyısoy , Cuneyt Ulutın
• Languages of publication: EN

Abstracts

EN

Recent advancements in curative-intent therapies have led to dramatic improvements in breast cancer-specific mortality but at the direct expense of increased risk of cardiovascular-related mortality. The use of radiation therapy has led to significant improvements in survival for patients treated for breast cancer. However, as patients live longer, the potentially serious adverse effects of radiation on the heart have raised concerns. Coronary artery disease following irradiation is encountered rarely but is one of the most devastating treatable complications.In this article we review the cardiac complications associated with radiation therapy.

Keywords

EN

Radiation therapy; Breast cancer; Acute myocardial infarction

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 2
• Pages: 180-183

Dates

published

1 - 4 - 2010

online

17 - 4 - 2010

Contributors

author

Turgay Celık

• School of Medicine, Department of Cardiology, Gulhane Military Medical Academy, 06018, Etlik-Ankara, Turkey

author

Cagdas Yuksel

• Department of Cardiology, Sarikamis Army District Hospital, 36500, Sarikamis, Turkey

author

Sait Demırkol

• Department of Cardiology, Malatya Army District Hospital, 44080, Malatya, Turkey

author

Atila Iyısoy

• School of Medicine, Department of Cardiology, Gulhane Military Medical Academy, 06018, Etlik-Ankara, Turkey

author

Cuneyt Ulutın

• School of Medicine, Department of Radiation Oncology, Gulhane Military Medical Academy, 06018, Etlik-Ankara, Turkey

References

• [1] Chung T. Cardiac effects of radiation therapy for malignancy. In: UpToDate, Rose, BD (ed). UpToDate, Wellesley, 2007
• [2] Lee PJ, Mallik R. Cardiovascular effects of radiation therapy: practical approach to radiation therapy-induced heart disease. Cardiol Rev. 2005; 13: 80–86 http://dx.doi.org/10.1097/01.crd.0000131188.41589.c5[Crossref]
• [3] Cuzick J, Stewart H, Rutqvist L, Houghton J, Edwards R, Redmond C, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 1994; 12: 447–453 [PubMed]
• [4] Hooning MJ, Aleman BM, Van Rosmalen AJ, et al. Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow up study. Int J Radiat Oncol Biol Phys 2006; 64: 1081
• [5] Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease. JAMA. 1993; 270: 1949–1955 http://dx.doi.org/10.1001/jama.270.16.1949[Crossref]
• [6] Glanzmann C, Huguenin P, Lutolf UM, Maire R, Jenni R, Gumppenberg V. Cardiac lesions after mediastinal irradiation for Hodgkin’s disease. Radiother Oncol. 1994; 30: 43–54 http://dx.doi.org/10.1016/0167-8140(94)90008-6[Crossref]
• [7] Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet 2000; 355: 1757–1770
• [8] Early Breast Cancer Trialists’ Collaborative Group: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of randomized trials. Lancet 2005; 366: 2087–2106
• [9] Hooning MJ, Botma A, Aleman BM, Baaijens MH, Bartelink H, Klijn JG, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst 2007; 99: 365–375 http://dx.doi.org/10.1093/jnci/djk064[Crossref]
• [10] Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagyi GN, Goodwin JS. Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst 2005; 97: 419–24 http://dx.doi.org/10.1093/jnci/dji067[Crossref]
• [11] Marks LB, Yu X, Prosnitz RG, Zhou SM, Hardenbergh PH, Blazing M, et al. The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 2005; 63: 214–223
• [12] Seddon B, Cook A, Gothard L, Salmon E, Latus K, Underwood SR, Yarnold J. Detection of defects in myocardial perfusion imaging in patients with early breast cancer treated with radiotherapy. Radiother Oncol 2002; 64: 53–63 http://dx.doi.org/10.1016/S0167-8140(02)00133-0[Crossref]
• [13] Harris EE, Correa C, Hwang WT, Liao J, Litt HI, Ferrari VA, Solin LJ. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006; 24: 4100–4106 http://dx.doi.org/10.1200/JCO.2005.05.1037[Crossref]
• [14] Boivin JF, Hutchison GB, Lubin JH, Mauch P. Coronary artery disease mortality in patients treated for Hodgkin’s disease. Cancer. 1992; 69: 1241–1247
• [15] Carr ZA, Land CE, Kleinerman RA, Weinstock RW, Stovall M, Griem ML, Mabuchi K. Coronary heart disease after radiotherapy for peptic ulcer disease. Int J Radiat Oncol Biol Phys. 2005; 61: 842–850
• [16] Beckman, JA, Thakore, A, Kalinowski, BH, Harris JR, Creager MA. Radiation therapy impairs endothelium-dependent vasodilation in humans. J Am Coll Cardiol 2001; 37: 761 http://dx.doi.org/10.1016/S0735-1097(00)01190-6[Crossref]
• [17] Hendry JH, Akahoshi M, Wang LS, Lipshultz SE, Stewart FA, Trott KR. Radiation-induced cardiovascular injury. Radiat Environ Biophys. 2008; 47: 189–193 http://dx.doi.org/10.1007/s00411-007-0155-7[WoS][Crossref]
• [18] Van der Meeren A, Squiban C, Gourmelon P, Lafont H, Gaugler MH. Differential regulation by IL-4 and IL-10 of radiationinduced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells. Cytokine 1999; 11: 831–838 http://dx.doi.org/10.1006/cyto.1999.0497[Crossref]
• [19] Verheij M, Dewit LG, Boomgaard MN, Brinkman HJ, van Mourik JA. Ionizing radiation enhances platelet adhesion to the extracellular matrix of human endothelial cells by an increase in the release of von Willebrand factor. Radiat Res 1994; 137: 202–207 http://dx.doi.org/10.2307/3578813[Crossref]
• [20] Stewart FA, Heeneman S, te Poele J, Kruse J, Russel NS, Gijbels M, Daemen M. Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol 2006; 168: 649–658 http://dx.doi.org/10.2353/ajpath.2006.050409[Crossref]
• [21] Eltringham JR, Fajardo LF, Stewart JR. Adriamycin cardiomyopathy: enhanced cardiac damage in rabbits with combined drug and cardiac irradiation. Radiology 1975; 115: 471–472
• [22] Dalloz F, Maingon P, Cottin Y, Briot F, Horiot JC, Rochette L. Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat. Free Radic Biol Med. 1999; 26: 785–800 http://dx.doi.org/10.1016/S0891-5849(98)00259-7[Crossref]

Identifiers

DOI

10.2478/s11536-009-0068-8