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Journal
2009 | 4 | 4 | 490-495
Article title

The value of transabdominal ultrasound for assessment of the severity of liver steatosis as compared to liver biopsy

Content
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Languages of publication
EN
Abstracts
EN
The purpose of our paper was to evaluate the performance of ultrasound (US) for assessment of the severity of liver steatosis as compared to a pathological examination, which is presently considered to be the gold standard, in patients that have undergone liver biopsy for various reasons. We performed echo-assisted liver biopsy in 161 patients with chronic hepatitis with the US aspect of “bright liver” with “posterior attenuation”, using modified Menghini needles. Following the US examination, the severity of liver steatosis was estimated as minimal, mild, moderate. or severe according to the Hepburn classification: absent (affecting 0% to 2% of the hepatocytes), minimal (2% to 10%), mild (10% to 30%), moderate (30% to 60%), and severe (more than 60% of the hepatocytes). The results of this study showed that the sensitivity of US for the prediction of histological steatosis of at least moderate severity was 0.64, with 0.77 specificity, 0.55 positive predictive value, and 0.94 negative predictive value. The overall accuracy was 0.75. This study showed that the transabdominal ultrasound evaluation of the fatty liver is a quite good predictor, perhaps sufficient for most purposes, for the estimation of the severity of liver steatosis in the moderate to severe range.
Publisher

Journal
Year
Volume
4
Issue
4
Pages
490-495
Physical description
Dates
published
1 - 12 - 2009
online
3 - 10 - 2009
Contributors
author
  • Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România, isporea@excite.com
author
  • Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România
author
  • Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România
  • Department of Pathology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România
author
  • Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România
  • Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, 300736, Timişoara, România
author
  • Department of Biophysics and Medical Informatics, University of Medicine and Pharmacy Timişoara, 300173, Timişoara, România
References
  • [1] Zelber-Sagi S., Nitzan-Kaluski D., Halpern Z., Oren R., Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures., Liver International, 2006, 26, 856–863 http://dx.doi.org/10.1111/j.1478-3231.2006.01311.x[Crossref][WoS]
  • [2] Abdelmalek M.F., Diehl A.M., Nonalcoholic fatty liver disease as a complication of insulin resistance., Med. Clin. North. Am., 2007, 91(6),1125–1149 http://dx.doi.org/10.1016/j.mcna.2007.06.001[Crossref][WoS]
  • [3] Bedogni G., Bellentani S., Fatty liver, how frequent is it and why?, Ann. Hepatol., 2004, 3, 63–65 [PubMed]
  • [4] Negro F., Insulin resistance and HCV, will new knowledge modify clinical management?, Journal of Hepatology, 2006, 45, 514–519 http://dx.doi.org/10.1016/j.jhep.2006.07.011[Crossref]
  • [5] Falck-Ytter Y., Younossi Z.M., Marchesini G., McCullough A.J., Clinical feature and natural history of nonalcoholic steatosis syndromes., Semin. Liver. Dis., 2001, 21, 17–26 http://dx.doi.org/10.1055/s-2001-12926[Crossref]
  • [6] Ratziu V., Giral.P, Charlotte F., Bruckert E., Thibault V., Theodorou I. et al, Liver fibrosis in overweight patients., Gastroenterology, 2000, 118, 1117–1123 http://dx.doi.org/10.1016/S0016-5085(00)70364-7[Crossref]
  • [7] Adams L.A., Lymp J.F., Sauver J., Sanderson S.O., Lindor K.D., Feldstein A. et al, The natural history of nonalcoholic fatty liver disease, a population-based cohort study., Gastroenterology, 2005, 129, 113–121 http://dx.doi.org/10.1053/j.gastro.2005.04.014[Crossref]
  • [8] Munteanu M., Ratziu V., Morra R., Messous D., Imbert-Bismut F., Poynard T., Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience., J. Gastrointestin Liver Dis., 2008, 17(2), 187–191
  • [9] Lydatakis H., Hager I.-P., Kostadelou E., Mpousmpoulas S., Pappas S., Diamantis I., Noninvasive markers to predict the liver fibrosis in nonalcoholic fatty liver disease., Liver International, 2006, 26, 864–871 http://dx.doi.org/10.1111/j.1478-3231.2006.01312.x[Crossref]
  • [10] Sanyal A.J., AGA technical review on nonalcoholic fatty liver disease., Gastroenterology 2002, 123, 1705–1725 http://dx.doi.org/10.1053/gast.2002.36572[Crossref]
  • [11] Tobari M., Hashimoto E., Yatsuji S., Torii N., Taniai M., Tokushige K. et al, The usefulness of ultrasonography and computerized tomography in imaging of nonalcoholic steatohepatitis., Hepatology, 2006, 44(S1), 658A
  • [12] Browning J.D., Szczepaniak L.S., Dobbins R., Nuremberg P., Horton J.D., Cohen J.C. et al, Prevalence of hepatic steatosis in an urban population in United States: impact of ethnicity., Hepatology, 2004, 40, 1387–1395 http://dx.doi.org/10.1002/hep.20466[Crossref]
  • [13] Matteoni C.A., Younossi Z.M., Gramlich T., Boparai N., Liu Y.C., McCullough A.J., Nonalcoholic fatty liver disease, a spectrum of clinical and pathological severity., Gastroenterology, 1999, 116, 1413–1419 http://dx.doi.org/10.1016/S0016-5085(99)70506-8[Crossref]
  • [14] Al Knawy B., Shiffman M., Percutaneous liver biopsy in clinical practice., Liver Int. 2007, 27(9), 1166–1173 http://dx.doi.org/10.1111/j.1478-3231.2007.01592.x[Crossref]
  • [15] Hepburn J.M., Vos J.A., Fillman E.P., Lawitz E.J., The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: A retrospective observational study., BMC Gastroenterol., 2005, 5, 14–28 http://dx.doi.org/10.1186/1471-230X-5-14[Crossref]
  • [16] Palmentieri B., de Sio I., La Mura V., Masarone M., Vecchione R., Bruno S. et al, The role of liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis., Dig. Liver. Dis., 2006, 38, 485–489 http://dx.doi.org/10.1016/j.dld.2006.03.021[Crossref]
  • [17] Mathiesen U.L., Franzen L.E., Aselius H., Resjö M., Jacobsson L., Foberg U. et al, Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases., Dig. Liver. Dis., 2002, 34, 516–522 http://dx.doi.org/10.1016/S1590-8658(02)80111-6[Crossref]
  • [18] Fishbein M., Castro F., Cheruku S., Jain S., Webb B., Gleason T. et al, Hepatic MRI for fat quantification, its relationship to fat morphology, diagnosis and ultrasound., J. Clin. Gastroenterol., 2005, 39, 619–625 http://dx.doi.org/10.1097/00004836-200508000-00012[Crossref]
  • [19] Kim S.H., Lee J.M., Kim J.M., Kim K.G., Han J.K., Lee K.H. et al, Appropriateness of a donor liver with respect to macrosteatosis, application of artificial neural networks to US images- initial experience., Radiology, 2005, 234, 793–803 http://dx.doi.org/10.1148/radiol.2343040142[Crossref]
  • [20] Gaitini D., Lederman M., Baruch Y., Ghersin E., Veitsman E., Kerner H. et al, Computerized analysis of liver texture with correlation to needle biopsy., European J. Ultrasound 2005, 26, 197–202
  • [21] Ataseven H., Yildirim M.H., Yalniz M., Bahcecioglu I.H., Celebi S., Ozercan I.H., The value of ultrasonography and computerized tomography in estimating the histopathological severity of nonalcoholic steatohepatitis., Acta Gastroenterol. Belg., 2005, 68, 221–225
  • [22] Saadeh S., Younossi Z.M., Remer E.M., Gramlich T., Ong J.P., Hurley M. et al, The utility of radiological imaging in nonalcoholic fatty liver disease., Gastroenterology 2002, 123, 745–750 http://dx.doi.org/10.1053/gast.2002.35354[Crossref]
  • [23] Joseph A.E., Saverymuttu S.H., al-Sam S., Cook M.G., Maxwell J.D., Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease., Clin. Radiol., 1991, 43, 26–31 http://dx.doi.org/10.1016/S0009-9260(05)80350-2[Crossref]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0067-9
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