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Journal

2009 | 4 | 3 | 299-303

Article title

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

Content

Title variants

Languages of publication

EN

Abstracts

EN
In the course of cirrhosis, a variety of disturbances of endocrine glands occur. Degenerative changes in the testes with atrophia and fibrosis of the glandular tissue are often found in men. Twenty-one males with compensated alcoholic liver cirrhosis were studied. The age ranged from 29 to 61 years (mean 47,1). Efficiency of the liver was evaluated according to Child classification. HBC (this needs to be spelled out in parenthesis) or HBV (Hepatitis B Virus) infections were excluded. Levels of serum testosterone were determined and the volume size of the testes was measured using 7,5 MHz sector probe, B&K Medical ultrasonograph, 3535 model. Volume size of the testes was measured in 22 healthy control volunteers, as well; age ranged from 25 to 66 years (mean-46,6). All patients were interviewed about sexual function, particularly possible erectile dysfunction using IIEF-5 questionnaire. The mean testosterone level was 8,89 umol/l (ranged: 7,4–10,9 umol/l) in the study patients [the normal range interval: 8,2–34,6 umol/l]. The level was below the normal range in 4 patients, and low but within the normal range in the remaining patients. Statistically significant lower values of both testes volumes were estimated in patients with compensated alcoholic liver cirrhosis in comparison to healthy controls (p<0,001), however only 5 (23,81 %) study group subjects admitted impaired libido and erectile dysfunction. Decreased levels of testosterone in the peripheral blood and diminished volume size of testes are found in patients suffering from alcoholic liver cirrhosis. Erectile dysfunction in patients with liver cirrhosis needs further evaluation.

Publisher

Journal

Year

Volume

4

Issue

3

Pages

299-303

Physical description

Dates

published
1 - 9 - 2009
online
3 - 7 - 2009

Contributors

  • 1st Dept. of Urology, Medical University, 90-549, Łódź, Poland
author
  • Department of Infectious Diseases and Hepatology, Medical University, 91-347, Łódź, Poland
  • 1st Dept. of Urology, Medical University, 90-549, Łódź, Poland
  • 1st Dept. of Urology, Medical University, 90-549, Łódź, Poland
  • Department of Surgery and Thoracosurgery, Medical University of Łódź, 90-549, Łódź, Poland
  • Department of Infectious Diseases and Hepatology, Medical University, 91-347, Łódź, Poland

References

  • [1] www.merck.com/The Merck Manual of Diagnosis and Therapy/Section 4. Hepatic And Biliary Disorders/Chapter 41. Chronic Liver Disease/Cirrhosis
  • [2] Hasselblatt M., Krieg-Hartig Ch., Hufner M., Halaris A., Ehrenreich H.: Persistent disturbance of the hypothalamic-pituitary-gonadal axis in abstinent alcoholic men. Alcohol Alcohol, 2003, 38,3, 239–242 [PubMed][Crossref]
  • [3] Karagiannis A., Harsoulis A.: Gonadal dysfunction in systemic diseases. Eur J Endocrinol, 152,4, 501–513
  • [4] Maria N., Colantoni A. van Thiel DH.: The liver and endocrine function. In: Principles and Practice of Endocrinology and Metabolism, edn 3, ch. 205, pp 1870–1885. Ed. KL Becker. Philadelphia: Lippincott Williams & Wilkins, 2000
  • [5] Frias J., Torres J.M., Miranda M.T., Ruiz E., Ortega M.: Effects of acute alcohol intoxication on pituitarygonadal axis hormones, pituitary-adrenal axis hormones, beta-endorphin and prolactin in human adults of both sexes. Alcohol Alcohol, 2002, 37, 169–173 [Crossref]
  • [6] Yamauchi M, Takeda K, Sakamoto K, Searashi Y, Uetake S, Kenichi And H, Toda G.: Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-induced testicular atrophy. Alcohol Clin Exp Res, 2001, 25(6 Suppl):16S–18S
  • [7] Pajarinen J.T., Karhunen PJ.: Spermatogenic arrest and ’sertoli cell-only’ syndrome-common alcoholinduced disorders of the human testis. Int J Androl., 1994, 17, 292–299 http://dx.doi.org/10.1111/j.1365-2605.1994.tb01259.x[Crossref]
  • [8] Sosnik H.: Studies on the size of human male gonad in biomorphosis, alcohol intoxication, and cirrhosis-a review and own findings. Gegenbaurs Morphol Jahrb. 1988;134,733–761
  • [9] Garcia-Valdecasas-Campelo E., Gonzalez-Reimers E., Santolaria-Fernandez F., De La Vega-Prieto M.J., Milena-Abril A., Sanchez-Perez M.J., Martinez-Riera A., Gomez-Rodriguez M.D.: Serum osteoprotegerin and rankl levels in chronic alcoholic liver disease. Alcohol Alcohol., 2006, 41, 261–266 [Crossref]
  • [10] Nguyen H.V., Mollison L.C., Taylor T.W., Chubb S.A., Yeap B.B.: Chronic hepatitis C infection and sex hormone levels: effect of disease severity and recombinant interferon-alpha therapy. Intern Med J. 2006, 36, 362–366 http://dx.doi.org/10.1111/j.1445-5994.2006.01093.x[Crossref]
  • [11] Toda K., Miwa Y., Kuriyama S., Fukushima H., Shiraki M., Murakami N., Shimazaki M., Ito Y., Nakamura T., Sugihara J., Tomita E., Nagata C., Suzuki K., Moriwaki H.: Erectile dysfunction in patients with chronic viral liver disease: its relevance to protein malnutrition. J Gastroenterol. 2005, 40, 894–900 http://dx.doi.org/10.1007/s00535-005-1634-8[Crossref]
  • [12] Simsek I, Aslan G, Akarsu M, Koseoglu H, Esen A.: Assessment of sexual functions in patients with chronic liver disease. Int J Impot Res. 2005,17, 343–345 http://dx.doi.org/10.1038/sj.ijir.3901316[Crossref]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-009-0050-5
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