Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results

Journal

2009 | 4 | 3 | 286-292

Article title

Transfusion associated in-hospital mortality and morbidity in isolated Coronary Artery Bypass Graft surgery

Content

Title variants

Languages of publication

EN

Abstracts

EN
Transfusion after cardiac surgery is very common. This rate varies between institutions and has remained high despite established transfusion guidelines. We analyzed our database of patients who underwent isolated CABG (Coronary Artery Bypass Graft) to determine the predictive factors of homologous transfusion and associated postoperative morbidity, mortality and resource utilization. All 14,152 patients who underwent first-time isolated CABG, with or without cardiopulmonary bypass (CPB) who had postoperative homologous transfusion between February 2002 and March 2008 in Tehran Heart Center, were evaluated retrospectively. Overall, 16.5% of patients received transfusion. Transfused patients demonstrated a significantly higher incidence of postoperative complications (cardiac, infectious, ischemic, reoperation) and mortality (p<0.001). Homologous blood transfusion effect on mortality, morbidity and resource utilization. By Multivariable logistic regression analysis adjusted for confounders: Homologous blood transfusion effect on Mortality (30-days) (OR=3.976, p<0.0001), Prolonged ventilation hours (OR=4.755, p<0.0001), Total ICU hours (β =14.599, p<0.0001), Hospital length of stay (β =1.141, p<0.0001), Post surgery length of stay (β =0.955, p<0.0001). We conclude that the isolated CABG patients receiving blood transfusion have significantly higher mortality, morbidity and resource utilization. Homologous blood transfusion is an independent factor of increased resource utilization, morbidity and mortality.

Keywords

Publisher

Journal

Year

Volume

4

Issue

3

Pages

286-292

Physical description

Dates

published
1 - 9 - 2009
online
3 - 7 - 2009

Contributors

  • Cardiovascular Surgery Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
  • Cardiovascular Surgery Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
  • Cardiovascular Surgery Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
author
  • Clinical Reaserch Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
  • Clinical Reaserch Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
  • Clinical Reaserch Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran
author
  • Clinical Reaserch Department, Tehran Heart Center, Medical Sciences/ Univercity of Tehran, Tehran, 1411713138, Iran

References

  • [1] Manchal N, Jayaram S., A prospective cohort study on anemia and blood transfusion in critically ill patients. Indian J Crit Care Med 2007;11:182–185 http://dx.doi.org/10.4103/0972-5229.37712[Crossref]
  • [2] Andrew F. Shorr and William L. Jackson. Transfusion Practice in the ICU, J Chest 2005;127:702–705 http://dx.doi.org/10.1378/chest.127.3.702[Crossref]
  • [3] Ramnath AN, Naber HR, de Boer A, Leusink JA No benefit of intraoperative whole blood sequestration and autotransfusion during coronary artery bypass grafting: results of a randomized clinical trial., J Thorac Cardiovasc Surg 2003;125:1432–1437 http://dx.doi.org/10.1016/S0022-5223(03)00105-3[Crossref]
  • [4] Andreasen JJ, Westen M, Pallesen PA, Jensen S, Gorst-Rasmussen A, Johnsen SP., Transfusion practice in coronary artery bypass surgery in Denmark: a multicenter audit., J. Interact Cardiovasc Thorac Surg 2007;6:623–627 http://dx.doi.org/10.1510/icvts.2007.154401[Crossref]
  • [5] Putney LJ., Bloodless cardiac surgery: not just possible, but preferable., Crit Care Nurs Q 2007;30:263–270
  • [6] Whitson BA, Huddleston SJ, Savik K, Shumway SJ., Bloodless cardiac surgery is associated with decreased morbidity and mortality. J Card Surg 2007;22:373–378 http://dx.doi.org/10.1111/j.1540-8191.2007.00428.x[WoS][Crossref]
  • [7] Leal-Noval S.R., Rincon-Ferrari M.D., Garcia-Curiel A., et al., Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery, Chest., 2001, 119, 1461–1468 http://dx.doi.org/10.1378/chest.119.5.1461[Crossref]
  • [8] Karimi A, Ahmadi H, Davoodi S, Movahedi N, Marzban M, Abbasi K, Omran AS, Sadeghian S, Yazdanifard P, Abbasi SH, Fallah N., Factors affecting postoperative morbidity and mortality in isolated coronary artery bypass graft surgery. Surg Today 2008;38:890–898 http://dx.doi.org/10.1007/s00595-007-3733-z[Crossref][WoS]
  • [9] Shander A., Moskowitz D., Rijhwani TS., The safety and efficacy of “bloodless” cardiac surgery, J. Semin Cardiothorac Vasc Anesth., 2005, 9, 53–63 http://dx.doi.org/10.1177/108925320500900106[Crossref]
  • [10] Stover E.P., Siegel L.C., Parks R., et al., Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines., A 24- institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group, Anesthesiology., 1998, 88, 327–333 http://dx.doi.org/10.1097/00000542-199802000-00009[Crossref]
  • [11] Bjortuft O., Geiran O.R., Fjeld. J, et al., Single lung transplantation for chronic obstructive pulmonary disease: Pulmonary function and impact of bronchiolitis obliterans syndrome, Respir Med., 1996, 90, 553–559 http://dx.doi.org/10.1016/S0954-6111(96)90148-1[Crossref]
  • [12] Engoren M.C., Habib R.H., Zacharias A., Schwann T.A., Riordan C.J., Durham S.J., Effect of blood transfusion on long-term survival after cardiac operation, Ann Thorac Surg., 2002, 74(4), 1180–1186 http://dx.doi.org/10.1016/S0003-4975(02)03766-9[Crossref]
  • [13] Kuduvalli M., Oo A.Y., Newall N., Grayson A.D., Jackson M., Desmond M.J., Fabri B.M., Rashid A., Effect of peri-operative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery, Eur J Cardiothorac Surg., 2005, 27(4), 592–598 http://dx.doi.org/10.1016/j.ejcts.2005.01.030
  • [14] Magovern J.A., Sakert T., Benckart D.H., et al., A model for predicting transfusion after coronary artery bypass grafting, Ann Thorac Surg., 1996, 61, 27–32 http://dx.doi.org/10.1016/0003-4975(95)00808-X[Crossref]
  • [15] Moskowitz D.M., Klein J.J., Shander A., et al., Predictors of transfusion requirements for cardiac surgical procedures at a blood conservation center, Ann Thorac Surg., 2004, 77, 626–634 http://dx.doi.org/10.1016/S0003-4975(03)01345-6[Crossref]
  • [16] Leal-Noval S.R., Rincon-Ferrari M.D., Garcia-Curiel A., et al., Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery, Chest., 2001, 119, 1461–1468 http://dx.doi.org/10.1378/chest.119.5.1461[Crossref]
  • [17] Zacharias A., Habib R.H., Factors predisposing to median sternotomy complications, J. Deep vs superficial infection, Chest., 1996, 110, 1173–1178 [Crossref]
  • [18] Michalopoulos A., Stavridis G., Geroulanos S., Severe sepsis in cardiac surgical patients, Eur J Surg., 1998, 164, 217–222 http://dx.doi.org/10.1080/110241598750004670[Crossref]
  • [19] McBride W M.S., The balance of pro- and antiinflammatory cytokines in cardiac surgery, Curr Opin Anaesthesiol., 1998, 11, 15–22 http://dx.doi.org/10.1097/00001503-199802000-00004[Crossref]
  • [20] Laffey J.G., Boylan J.F., Cheng D.C., The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist, Anesthesiology., 2002, 97, 215–252 http://dx.doi.org/10.1097/00000542-200207000-00030[Crossref]
  • [21] Fransen E., Maessen J., Dentener M., Senden N., Buurman W., Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery, Chest., 1999, 116, 1233–1239 http://dx.doi.org/10.1378/chest.116.5.1233[Crossref]
  • [22] Van Bommel J., deKorte D., Lind A., et al., The effect of the transfusion of stored RBC’s on intestinal microvascular oxygenation in the rat, Transfusion., 2001, 41, 1515–1523 http://dx.doi.org/10.1046/j.1537-2995.2001.41121515.x[Crossref]
  • [23] D’Almeida MS., Jagger J., Duggan M., et al., A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion, Trans Med., 2000, 10, 291–303 http://dx.doi.org/10.1046/j.1365-3148.2000.00267.x[Crossref]
  • [24] Habib R.H., Zacharias A., Engoren M., Determinants of prolonged mechanical ventilation after coronary artery bypass grafting, Ann Thorac Surg., 1996, 62(4), 1164–1171 http://dx.doi.org/10.1016/0003-4975(96)00565-6[Crossref]
  • [25] Vamvakas E.C, Carven J.H., RBC transfusion and postoperative length of stay in the hospital or the intensive care unit among patients undergoing coronary artery bypass graft surgery: the effects of confounding factors, Transfusion., 2000, 40(7), 832–839 http://dx.doi.org/10.1046/j.1537-2995.2000.40070832.x[Crossref]
  • [26] Ovrum E., Am Holen E., Tangen G., Consistent nonpharmacologic blood conservation in primary and reoperative coronary artery bypass grafting, Eur J Cardiothoracic Surg., 1995, 9, 30–35 http://dx.doi.org/10.1016/S1010-7940(05)80045-4[Crossref]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-009-0044-3
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.