Brain abscesses represent organized foci of suppuration within the parenchyma. In this paper, we describe the case of a 3-month old girl with a large, complicated cerebral abscess. In addition, the course of treatment is presented. The patient’s recovery was excellent. The follow-up MRI showed only subtle porencephalic changes as the only parenchymal sequels, which may have been due to central nervous system (CNS) plasticity in infants.