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Journal

2009 | 4 | 3 | 279-285

Article title

Neoangiogenesis after direct intramyocardial implantation of bone marrow-derived stem cells in a patient with severe coronary artery disease ineligible for percutaneous or surgical revascularization

Content

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Languages of publication

EN

Abstracts

EN
Bone marrow-derived stem cells (BMSC) may be an alternative for the treatment of patients with severe coronary artery disease ineligible for either percutaneous or surgical revascularization. This case report presents a 65-year-old male patient with untreatable angina pectoris (Canadian Cardiovascular Society Class III) and severe coronary artery disease. A mixture of BMSC containing approximately 3×106 CD34+ cells was directly injected into preoperatively determined ischemic regions of the myocardium by median sternotomy. At baseline, at 3 months, and at 1 year of follow-up, echocardiography (demonstrating wall motions of 16 segments), single-photon emission computed tomography, and coronary angiography (at baseline and at 1 year) were performed to assess myocardial perfusion, left ventricular (LV) function and coronary anatomy. The patient reached Canadian Cardiovascular Society Class I after 6 months of cell implantation. The ejection fraction increased from 34% to 37% at the third month and 40% at 1 year of follow-up. At 1 year of follow-up, preoperatively akinetic mid-base septum and anteroseptal regions progressed to mild hipokinesia and severe hypokinetic mid-base-apical anterior regions and apical lateral-inferior regions became normokinesia. Single-photon emission computed tomography revealed a visible improvement in anterior and lateral segments at 1 year of follow-up. Coronary angiography showed newly developed collateral arteries at 1 year of follow-up. BMSC transplantation in a patient with severe coronary artery disease resulted in increase of LV ejection fraction, an increase of the perfusion of ischemic myocardial regions, and improvement in wall motion defects without any adverse events.

Publisher

Journal

Year

Volume

4

Issue

3

Pages

279-285

Physical description

Dates

published
1 - 9 - 2009
online
3 - 7 - 2009

Contributors

  • Department of Cardiovascular Surgery, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey
author
  • Department of Cardiovascular Surgery, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey
author
  • Department of Cardiovascular Surgery, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey
author
  • Department of Haematology, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey
author
  • Department of Haematology, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey
author
  • Department of Haematology, Istanbul University, Istanbul Medical Faculty, 34093, Capa, Istanbul, Turkey

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-009-0035-4
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