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Journal
2009 | 4 | 4 | 450-453
Article title

The effects of tamoxifen on homocysteine levels in breast cancer patients

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EN
Abstracts
EN
Tamoxifen is widely used in the treatment of breast cancer and associated with an increased risk of thromboembolism (TE). An elevated homocysteine is one of the risk factors for TE. The aim of the study was to assess the effect of tamoxifen on serum homocysteine levels in breast cancer patients. We performed a case-control study in 20 female subjects to evaluate the relationship between homocysteine levels, and 5,10-methylenetetrahyrofolate reductase (MTHFR) C677T and dihydrofolate reductase (DHFR) 19-bp intron-1 deletion polymorphisms in breast cancer patients and in control subjects. It was observed that homocysteine levels were decreased during tamoxifen therapy, but this finding was not statistically significant. There was also no statistically significant difference in homocysteine levels between the two groups (p> 0.05). MTHFR C677T and DHFR 19-bp deletion polymorphisms were not associated with serum homocysteine value in either group.
Keywords
Publisher

Journal
Year
Volume
4
Issue
4
Pages
450-453
Physical description
Dates
published
1 - 12 - 2009
online
3 - 10 - 2009
Contributors
author
  • Department of General Surgery, Ankara University Medical School, 06590, Ankara, Turkey, aydaneroglu@gmail.com
author
  • Department of Pediatric Molecular Genetic, Ankara University Medical School, 06590, Ankara, Turkey
author
  • Department of Pediatric Molecular Genetic, Ankara University Medical School, 06590, Ankara, Turkey
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0020-y
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