Teat tablet with sodium ibuprofen: the effect of sorbitol on therapeutic agent pharmaceutical availability and on physicochemical parameters of a drug form

• Authors: Aneta Berner-Strzelczyk , Justyna Kołodziejska , Magdalena Piechota-Urbañska , Mariusz Piechota , Marian Zgoda
• Languages of publication: EN

Abstracts

EN

Dosing pediatric drugs available on pharmaceutical markets of analgesic, antifebrile and anti-inflammatory activity to children up to 3 years of age is not precise and frequently causes problems. The aim of the study was to work out a pediatric teat form of a drug with sodium ibuprofen and to determine the effect of sorbitol content on pharmaceutical availability of the therapeutic agent. Three variants of tablets containing 50 mg of sodium ibuprofen differing in the percentage content of sorbitol (from 37% - batch I to 79% - batch III) were produced. Quality tests of the produced forms of drugs (PPVI) were performed and the tests of therapeutic agent pharmaceutical availability by spatula method and by a method with a teat. Tablets of all batches had a smooth surface and same shape. The content of the therapeutic agent was within the limit of 95-105% of the declared value. The highest value of Q coefficient in the release test by pharmacopeal method and the shortest disintegration time (12 minutes) were obtained for tablets with 79% content of sorbitol. In conclusion, teat tablets with sodium ibuprofen of the highest sorbitol content (79%) demonstrated the expected physicochemical parameters and high pharmaceutical availability.

Keywords

EN

Sorbitol; Sodium; Ibuprofen; Teat tablet; Dissolution test

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2009
• Volume: 4
• Issue: 1
• Pages: 98-103

Dates

published

1 - 3 - 2009

online

11 - 2 - 2009

Contributors

author

Aneta Berner-Strzelczyk

• Department of Applied Pharmacy, Medical University of Lodz, 90-151, Lodz, Poland

author

Justyna Kołodziejska

• Department of Applied Pharmacy, Medical University of Lodz, 90-151, Lodz, Poland

author

Magdalena Piechota-Urbañska

• Department of Applied Pharmacy, Medical University of Lodz, 90-151, Lodz, Poland

author

Mariusz Piechota

• Department of Anaesthesiology and Intensive Care Unit, Boleslaw Szarecki University Hospital No. 5 in Lodz, Medical University of Lodz, 90-647, Lodz, Poland

author

Marian Zgoda

• Department of Applied Pharmacy, Medical University of Lodz, 90-151, Lodz, Poland

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Identifiers

DOI

10.2478/s11536-008-0087-x