The current analysis of the effect of hyperbaric oxygen therapy on the frostbitten tissue: Experimental study in rabbits

• Authors: Fatih Uygur , Nurettin Noyan , Celalettin Sever , Tuna Gümüş
• Languages of publication: EN

Abstracts

EN

Many experimental studies have been performed and the mechanism of hyperbaric oxygen therapy on the frostbitten tissue has not been elucidated. In this study, we evaluated the effect of hyperbaric oxygen therapy on the frostbitten ears of rabbits in an experimental animal model by examining the concentrations of thromboxane A2 (as thromboxane B2-Tx B2) and of prostaglandin I2 (PG I2) (as 6-keto-prostaglandin F1α-PG F1α) in tissues, and by counting the numbers of inflammatory cells (neutrophils and mast cells-MC) Hyperbaric oxygen therapy (HBO) at 2.5 ATA for 90 minutes twice daily for fourteen days to rabbits, the ears of which were subjected to frostbite, decreased presence of inflammatory cells (mast cells −75%; neutrophils −40%) and increased prostaglandin I2 (PG I2) (as 6-Keto-PGF1α) in the involved skin. Thromboxane A2 (TxA2) (as Tx B2) was unaffected. Our results revealed that an inflammatory process was the underlying cause of frostbite injury and that hyperbaric oxygen therapy was active in pathological situations involving an inflammatory process in frostbite.

Keywords

EN

Hyperbaric Oxygen Therapy; Frostbite; Arachidonic acid metabolism

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2009
• Volume: 4
• Issue: 2
• Pages: 198-202

Dates

published

1 - 6 - 2009

online

27 - 3 - 2009

Contributors

author

Fatih Uygur

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpasha Training Hospital, 34668, Istanbul, Turkey

author

Nurettin Noyan

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpasha Training Hospital, 34668, Istanbul, Turkey

author

Celalettin Sever

• Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpasha Training Hospital, 34668, Istanbul, Turkey

author

Tuna Gümüş

• Department Of Undersea and Hyperbaric Medicine, Kasimpasha Military Hospital, 34440, Istanbul, Turkey

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Identifiers

DOI

10.2478/s11536-008-0054-6