No association between vulvovaginitis-bacterial vaginosis, related drug treatments of pregnant women, and congenital abnormalities in their offspring - A population-based case-control study

• Authors: Nándor Ács , Ferenc Bánhidy , Erzsébet Puhó , Andrew Czeizel
• Languages of publication: EN

Abstracts

EN

The possible association between prospectively and medically recorded vulvovaginitis-bacterial vaginosis (VV-BV) and different congenital abnormalities (CA) has not been studied. The data set of the population-based Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996 were evaluated, i.e. 22,843 pregnant women who had newborns or fetuses with congenital abnormality (cases) and 38,151 pregnant women who delivered newborn babies without any congenital abnormality (controls). The main outcome measures were different congenital abnormalities. Of 22,843 cases with CA, 1,536 (6.7%) had mothers with VV-BV, while of 38,151 matched controls without CA, 2,698 (7.1%) had mothers with VV-BV in the second and/or third gestational month of pregnancy. Nearly all pregnant women with VV-BV were treated during pregnancy, but a higher risk for the total group of CAs (adjusted POR with 95% CI: 0.95, 0.89–1.02) or any CA group was not found. In addition, the risk for total CAs was significantly lower in cases born to mothers with VV-BV and appropriate treatment than born to mothers with VV-BV but without treatment. Thus maternal VV-BV needs treatment during pregnancy as well, because it helps reduce the rate of preterm birth without a risk for CAs.

Keywords

EN

Vulvovaginitis-bacterial vaginosis; Congenital abnormalities; Population-based case-control study

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 3
• Pages: 332-340

Dates

published

1 - 9 - 2008

online

10 - 7 - 2008

Contributors

author

Nándor Ács

• Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary

author

Ferenc Bánhidy

• Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary

author

Erzsébet Puhó

• Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary

author

Andrew Czeizel

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Identifiers

DOI

10.2478/s11536-008-0027-9