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2008 | 3 | 4 | 446-452

Article title

Cross-resistance and associated resistance in Escherichia coli isolates from nosocomial urinary tract infections between 2004–2006 in a Turkish Hospital


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In this study, antimicrobial resistance profiles were determined for 748 isolates of Escherichia coli from patients with acute nosocomial urinary tract infections (UTIs) at a Turkish Training Hospital. Thirteen antibiotics were included. Resistance to ampicillin alone (45.1%) and ciprofloxacin alone (20.6%) were the most commonly identified ‘single resistances’. Multiple resistance was found in 49.7% of the strains. The most common multiple antibiotic resistance profiles included ampicillin-sulbactam/amoxycilline-clavulonate (4.0%) and ampicillin-sulbactam/trimethoprim-sulfamethoxazole/amoxycilline-clavulonate (2.8%). From 2004 to 2006, ampicillin, trimethoprim-sulfamethoxazole and ciprofloxacin resistant strains increased to 76% from 57%, 53% from 43% and 55% from 41%, respectively. The percentage of extended-spectrum β-lactamase (ESBL) producing strains was 7.8% and imipenem resistance was seen in 5.2% of ESBL positive strains. We conclude that clinically important E.coli strains have now emerged with broader multidrug resistance. Periodical evaluation of laboratory results and clinical surveillance are crucially important for optimal antibiotic management of UTIs and infection control policies.










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1 - 12 - 2008
22 - 10 - 2008


  • Haydarpasa Training Hospital, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey
  • Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey
  • Haydarpasa Training Hospital, Department of Epidemiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey
  • Haydarpasa Training Hospital, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey
  • Haydarpasa Training Hospital, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey
  • Haydarpasa Training Hospital, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, 34100, Uskudar, Istanbul, Turkey


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