Review of surfactin chemical properties and the potential biomedical applications

• Authors: Gabriela Seydlová , Jaroslava Svobodová
• Languages of publication: EN

Abstracts

EN

Surfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a β-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.

Keywords

EN

Antimicrobial resistance; Biosurfactants; Lipopeptide antibiotics; Membrane; Surfactin; Therapeutic agents

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 2
• Pages: 123-133

Dates

published

1 - 6 - 2008

online

9 - 4 - 2008

Contributors

author

Gabriela Seydlová

• Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, 128 44, Praha 2, Czech Republic

author

Jaroslava Svobodová

• Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, 128 44, Praha 2, Czech Republic

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Identifiers

DOI

10.2478/s11536-008-0002-5