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2008 | 3 | 2 | 123-133

Article title

Review of surfactin chemical properties and the potential biomedical applications


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Surfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a β-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.










Physical description


1 - 6 - 2008
9 - 4 - 2008


  • Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, 128 44, Praha 2, Czech Republic
  • Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, 128 44, Praha 2, Czech Republic


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