Safety and efficacy of two protocols for sedation in pediatric oncology procedures

• Authors: Francesca Crea , Antonio Ruggiero , Orazio Genovese , Luca Tortorolo , Giulia Zorzi , Antonio Chiaretti
• Languages of publication: EN

Abstracts

EN

Invasive procedures, such as the lumbar puncture, can cause anxiety and pain in children undergoing treatment for acute lymphoblastic leukemia (ALL). We investigated the safety and efficacy of two different protocols for pain relief in 20 children with ALL undergoing lumbar puncture. Protocol A was composed of an association between propofol and alfentanil. Protocol B consisted in the combination of propofol and ketamine. Vital and behavioural parameters, sedation and pain scores were recorded at different times during and after the procedure. All patients showed a satisfactory sedation and analgesia. We found a statistically significant difference of vital parameters between protocol A and protocol B, while there were no significative differences between sedation scores and the other parameters evaluated. Patients in protocol A showed a higher incidence of major side effects, such as respiratory depression. Our results show that both protocols are effective to obtain a good sedation and analgesia in children with ALL undergoing lumbar puncture, but the association between propofol and ketamine appears more safe due to the lower incidence of side effects.

Keywords

EN

Childhood; Lumbar Puncture; Oncology; Pain; Sedation

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 1
• Pages: 77-82

Dates

published

1 - 3 - 2008

online

1 - 3 - 2008

Contributors

author

Francesca Crea

• Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy

author

Antonio Ruggiero

• Department of Pediatric Oncology, Catholic University Medical School, Rome, Italy

author

Orazio Genovese

• Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy

author

Luca Tortorolo

• Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy

author

Giulia Zorzi

• Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy

author

Antonio Chiaretti

• Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy

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Identifiers

DOI

10.2478/s11536-008-0001-6