Strategies to invent cardiovascular drugs targeting cardiac gap junctions

• Authors: Xu Han-You
• Languages of publication: EN

Abstracts

EN

In order to prevent and treat cardiac diseases, the author proposed strategies to invent cardiovascular drugs targeting cardiac gap junctions through summarizing the functions, physiology and pathophysiology of cardiac gap junctions. The 5 principle strategies to invent cardiovascular drugs that are suggested have great potentialities to be used as novel proposals to treat and prevent cardiac diseases.

Keywords

EN

Cardiac gap junctions; Cardiovascular; Pharmacology

• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 3
• Pages: 254-256

Dates

published

1 - 9 - 2008

online

10 - 7 - 2008

Contributors

author

Xu Han-You

• Department of Emergency Medicine, Clinical Institute, Xin Ye County People’s Hospital, Henan Province, China,

References

• [1] Wit A.L., Duffy H.S., Drug Development for Treatment of Cardiac Arrhythmias. Targeting the Gap Junctions. Am. J. Physiol. Heart Circ. Physiol., 2007, (in press) [WoS]
• [2] Kanno S., Saffitz JE., The role of myocardial gap junctions in electrical conduction and arrhythmogenesis. Cardiovasc. Pathol., 2001, 10, 169–177. http://dx.doi.org/10.1016/S1054-8807(01)00078-3[Crossref]
• [3] Teunissen B.E., Bierhuizen M.F., Transcriptional control of myocardial connexins. Cardiovasc. Res., 2004, 62, 246–255 http://dx.doi.org/10.1016/j.cardiores.2003.12.011[Crossref]
• [4] Dhein S., Polontchouk L., Salameh A., Haefliger J.A., Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40. Biol. Cell., 2002, 94, 409–422 http://dx.doi.org/10.1016/S0248-4900(02)00018-7[Crossref]
• [5] Garcia-Dorado D., Ruiz-Meana M., Padilla F., Rodriguez-Sinovas A., Mirabet M., Gap junctionmediated intercellular communication in ischemic preconditioning. Cardiovasc. Res., 2002, 55, 456–465 http://dx.doi.org/10.1016/S0008-6363(02)00441-8[Crossref]

Identifiers

DOI

10.2478/s11536-007-0064-9