Influence of cadmium and copper on tissue element levels of pregnant rats

• Authors: Sebahat Turgut , Yaşar Enli , Gülten Emmungil , Günfer Turgut , Süleyman Demir , Bünyamin Kaptanoglu , Osman Genç
• Languages of publication: EN

Abstracts

EN

In the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.

Keywords

EN

Pregnancy; cadmium; copper; fetus; rat

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2007
• Volume: 2
• Issue: 4
• Pages: 447-457

Dates

published

1 - 12 - 2007

online

1 - 12 - 2007

Contributors

author

Sebahat Turgut

• Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Yaşar Enli

• Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Gülten Emmungil

• Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Günfer Turgut

• Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Süleyman Demir

• Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Bünyamin Kaptanoglu

• Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

author

Osman Genç

• Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey

References

• [1] D. Bagchi, M. Bagchi, S.J. Stohs, S.D. Ray, C.A. Kuszynski and H.G. Pruess: “Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention”, Toxicology, Vol. 148, (2000), pp. 187–197. http://dx.doi.org/10.1016/S0300-483X(00)00210-9[Crossref]
• [2] D. Gunnarsson, G. Nordberg, P. Lundgren and G. Selstam: “Cadmium-induced decrement of the LH receptor expression and cAMP levels in the testis of rats”, Toxicology, Vol. 183, (2003), pp. 57–63. http://dx.doi.org/10.1016/S0300-483X(02)00440-7[Crossref]
• [3] L. Jarup, M. Berglund, C.G. Elinder, G. Nordberg and M. Vahter: “Health effect of cadmium-exposure: a review of the literature and a risk estimate”, Scand J. Work Environ. Health, Vol. 24, (1988), pp. 240–246.
• [4] N. Itoh, Y. Fujita, H. Nakanishi, Y. Kawai, T. Mayumi, G.S. Hwang, K. Min, S. Onosaka, N. Muto and K. Tanaka: “Binding of Cd to metallothionein in the placenta of Cd-treated Mouse”, J. Toxicol. Sci., Vol. 21, (1996), pp. 19–27. [Crossref]
• [5] C.E. Casey and P.A. Walravens: “Trace elements”, In: R.C. Tsang and B.L. Nichols editors, Nutrition during infancy, Philadelphia: Hanley & Belfus (1988), pp. 190–215.
• [6] J.R. Prohaska: “Functions of trace elements in brain metabolism”, Physiol. Rev., Vol. 67, (1989), pp. 858–901.
• [7] P. Yasodhara, L.A. Ramaraju and L. Raman: “Trace minerals in pregnancy: copper and zinc”, Nutr. Res., Vol. 11, (1991), pp. 15–21. http://dx.doi.org/10.1016/S0271-5317(05)80146-0[Crossref]
• [8] M. Araya, B. Koletzko and R. Uauy: “Copper deficiency and excess in infancy: developing a research agenda”, J. Pediatr. Gastroenterol. Nutr., Vol. 37, (2003), pp. 422–429. http://dx.doi.org/10.1097/00005176-200310000-00005[Crossref]
• [9] H.H. Sandstead: “Requirements and toxicity of essential trace elements, illustrated by zinc and copper”, Am. J. Clin. Nutr., Vol. 61, (1995), pp. 621–624.
• [10] M. Torra, J. Figueras, M. Rodamilans, M. Brunet and J. Corbella: “Cadmium and zinc relationships in the liver and kidney of humans exposed to environmental cadmium”, Sci. Total Environ., Vol. 170, (1995), pp. 53–57. http://dx.doi.org/10.1016/0048-9697(95)04534-8[Crossref]
• [11] M. Yoshida, H. Ohta, Y. Yamauchi, Y. Seki, M. Sagi, K. Yamazaki and Y. Sumi: “Age-dependent changes in metallothionein levels in liver and kidney of the Japanese”, Biol. Trace Elem. Res., Vol. 63, (1998), pp. 167–175.
• [12] S.K. Tandon, S. Singh, S. Prasad and N. Mathur: “Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice”, Food Chem. Toxicol., Vol. 39, (2001), pp. 571–577. http://dx.doi.org/10.1016/S0278-6915(00)00167-8[Crossref]
• [13] L. Institoris, A. Papp, O. Siroki, B.D. Banerjee and I. Desi: “Immuno-and neurotoxicological investigation of combined subacute exposure with the carbamate pesticide propoxur and cadmium in rats”, Toxicology, Vol. 178, (2002), pp. 161–173. http://dx.doi.org/10.1016/S0300-483X(02)00239-1[Crossref]
• [14] A. Brown, J.D. Halls and A. Taylor: “Atomic spectrometry update-clinical materials, foods and beverages”, J. Analy. Atomic Spect., Vol. 1, (1986), pp. 21–35. http://dx.doi.org/10.1039/ja98601fx021[Crossref]
• [15] H. Korpela, R. Loueniva, E. Yrjanheikki, A. Kauppila: “Lead and cadmium concentrations in maternal and umbilical cord blood, amniotic fluid, placenta, and amniotic membranes”, Am. J. Obstet. Gynecol., Vol. 155, (1989), pp. 1086–1089.
• [16] R.M. Smith, R.M. Leach, L.D. Muller, L.C. Griel and D.E. Baker: “Effects of long-term dietary cadmium chloride on tissue, milk, and urine mineral concentrations of lactating dairy cows”, J. Anim. Sci., Vol. 69, (1991), pp. 4088–4096.
• [17] W.S. Webster: “Chronic cadmium exposure during pregnancy in the mouse: influence of exposure levels on fetal and maternal uptake”, J. Toxicol. Environ. Health., Vol. 24, (1988), pp. 183–192. http://dx.doi.org/10.1080/15287398809531152[Crossref]
• [18] A. Gupta, V. Gupta, R.C. Murthy and S.V. Chandra: “Neurochemical changes in developing rat brain after pre-and postnatal cadmium exposure”, Bull. Environ. Contam. Toxicol., Vol. 51, (1993), pp. 12–17. http://dx.doi.org/10.1007/BF00200994[Crossref]
• [19] G.D. Miller, T.F. Massaro, E. Koperek and E. Massaro: “Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rats”, Biol. Trace Elem. Res., Vol. 6, (1984), pp. 519–530. http://dx.doi.org/10.1007/BF02987205[Crossref]
• [20] M. Panemangalore and F. Bebe: “Effects of low oral lead and cadmium exposure and zinc status on heme metabolites in weanling rats”, Int. J. Occup. Med. Environ. Health, Vol. 9, (1996), pp. 141–151.
• [21] C.V. Nolan and Z.A. Shaikh: “Lead nephrotoxicity and associated disorders: biochemical mechanisms”, Toxicology, Vol. 73, (1992), pp. 127–146. http://dx.doi.org/10.1016/0300-483X(92)90097-X[Crossref]
• [22] F. Thévenod and J.M. Friedman: “Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K+ ATPase through proteasomal and endo-lysosomal proteolitic pathways”, FASEB J., Vol. 13, (1999), pp. 1751–1761.
• [23] S. Tsuruoka, K. Sugimoto, S. Muto, K. Nomiyama, A. Fujimura, M. Imai: “Acute effect of Cadmium-metallothionein on glucose and aminoacid transport across the apical membrane of the rabbit proximal tubule perfused in vitro”, J. Pharmacol. Exp. Ther., Vol. 292, (2000), pp. 769–777.
• [24] M. Webb: “Toxicological significance of metallothionein”, Experientia, Vol. 52, (1987), pp. 109–134.
• [25] H.M. Chan and M.G. Cherian: “Mobilization of hepatic cadmium in pregnant rats”, Toxicol. Appl. Pharmacol., Vol. 120, (1993), pp. 308–314. http://dx.doi.org/10.1006/taap.1993.1116[Crossref]
• [26] B. Lönnerdal: “Dietary Factors Influencing Zinc Absorption”, J. Nutr., Vol. 130, (2000), pp. 1378–1383.
• [27] S. Saito: “Role of metallothionein on Zn, Cd and Cu accumulation in liver of heavy metal-injected rats”, In: P. Collery, P. Bratter, V.N. Bratter, L. Khassanova, J.C. Etenne, editors, Metal ions in biology and medicine, Paris: John Libbery Eurotext Press, (1998), pp. 258–261.
• [28] R.A. Goyer: “Toxic and essential metal interactions”, Annu. Rev. Nutr., Vol. 17, (1997), pp. 37–50. http://dx.doi.org/10.1146/annurev.nutr.17.1.37[Crossref]
• [29] A. Barone, O. Ebesh, R.G. Harper and R.A. Wapnir: “Placental copper transport in rats: effects of elevated dietary zinc on fetal copper, iron and metallothionein”, J. Nutr., Vol. 128, (1998), pp. 1037–1041.
• [30] S. Aydemir and M. Özcan: “The effects of high copper and zinc on some hematological parameters in rats”, Turk J. Vet. Anim. Sci., Vol. 27, (2003), pp. 165–172.
• [31] S. Turgut, M. Ercan, G. Turgut, M. Zencir and O. Genç: “The effects of high zinc and copper on the kidney and heart”, Med. J. SDU, Vol. 7, (2000), pp. 35–42.
• [32] E.K. Gee, N.D. Grace, E.C. Firth and P.F. Fennessy: “Changes in liver copper concentration of thoroughbred foals from birth to 160 days of age and the effect of prenatal copper supplementation of their dams”, Aust. Vet. J., Vol. 78, (2000), pp. 347–353.
• [33] R.V. Zikic, A.S. Stajn, B.I. Ognjanovic, Z.S. Saicic, M.M. Kostic, S.Z. Pavlovic and V.M. Petrovic: “The effect of cadmium and selenium on the antioxidant enzyme activities in rat heart”, J. Environ. Pathol. Toxicol. Oncol., Vol. 17, (1998), pp. 259–264.

Identifiers

DOI

10.2478/s11536-007-0047-x