Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2007 | 2 | 3 | 280-293

Article title

Effects of GABAB receptor antagonists CGP63360, CGP76290A and CGP76291A on learning and memory processes in rodents


Title variants

Languages of publication



Data in literature that use methods for studying the learning and memory processes suggest that GABA and especially GABAB receptor antagonists may be active against amnesia. The aim of our study was to examine the effects of three new GABAB-antagonists on learning and memory processes. Active and passive avoidance tests with negative reinforcement in rats were used. The rats treated with different GABAB receptor antagonists showed improving effects in both tests (active and passive avoidances)on learning as well as on memory retention. There are some differences in their activities, probably due to its chemical structures. The phosphinic analogue CGP63360A is potent to the point that the benzoic one CGP76290A and the left isomer of the benzoic analogue CGP76291A has no effect. It may be concluded that the obtained results on the GABAB receptor antagonists could contribute to their pharmacological characteristics and might be of interest for potential clinical implication.










Physical description


1 - 9 - 2007
1 - 9 - 2007


  • Department of Pharmacology, Clinical Pharmacology and Drug Toxicology, Medical University, V. Aprilov str. 15A, Plovdiv, 4002, Bulgaria
  • Department of Pharmacology, Clinical Pharmacology and Drug Toxicology, Medical University, V. Aprilov str. 15A, Plovdiv, 4002, Bulgaria


  • [1] U. Karlsson and H.R. Olpe: “Late inhibitory postsynaptic potentials in rat prefrontal cortex may be mediated by GABA-B receptors”, Experientia Vol. 45, (1989), pp. 157–158. http://dx.doi.org/10.1007/BF01954857[Crossref]
  • [2] P. Andre, T. Ferrat, M. Steinmann and H.R. Olpe: “Increased acetylcholine and quisqualate responsiveness following blockade of GABA(B)receptors”, Eur. J. Pharmscol., Vol. 218, (1992), pp. 137–143. http://dx.doi.org/10.1016/0014-2999(92)90157-Y[Crossref]
  • [3] C. Castellano, J.D. Brioni and J.L. McGuaugh: “GABA-ergic modulation of memory”, In: L. Squire, E. Lindenlaub (Eds.), The Biology of Memory, Symposia Medica Hoechst, Schattauer, Stuttgart/New York., 1990, pp. 361–378.
  • [4] C. Mondadori, J. Jaekel and U. Preiswerk: “CGP 36742: the first orrally active GABA B blocker improves the cognitive performance of mice, rats and Rhesus monkeys”, Behav. Neural. Biol., Vol. 60, (1993), pp. 62–68. http://dx.doi.org/10.1016/0163-1047(93)90729-2
  • [5] D.J. Macey, W. Froestl, G.F. Koch and A. Markou: “Both GABA-B receptor agonists and antagonists decreased brain stimulation reward in the rat”, Neuropharmacology, Vol. 40, (2001), pp. 676–685. http://dx.doi.org/10.1016/S0028-3908(00)00204-5[Crossref]
  • [6] K. Chen, H-Z. Li, N. Ye, J. Zhang and J-J. Wang: “Role of GABA(B)receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpoditus nucleus neurons in vitro”, Brain Res. Bull., Vol. 67, (2005), pp. 310–318. http://dx.doi.org/10.1016/j.brainresbull.2005.07.004[Crossref]
  • [7] O. Deschaux, W. Froestl and C. Gottesmann: “Influence of GABA(B)and GABA(C) receptor antagonist on sleep-waiking cycle in the rat”, Eur. J. Pharmacol., Vol. 535, (2006), pp. 177–181. http://dx.doi.org/10.1016/j.ejphar.2006.01.066[Crossref]
  • [8] A. Handforth, M. DeLorey, G.E. Homanics and R.W. Olsen: “Pharmacologic evidence for abnormal thalamocortical functioning in GABA(A)receptor β3 subunit-defficient mice,a model of Angelman syndrome”, Epilepsia, Vol. 46, (2005), pp. 1860–1870. http://dx.doi.org/10.1111/j.1528-1167.2005.00287.x
  • [9] D. Getova, N.G. Bowery and V. Spassov: “Effects of GABA-B receptor antagonists on learning and memory retention in a rat model of absence epilepsy”, Eur. J. Pharmacol., Vol. 320, (1997), pp. 9–13. http://dx.doi.org/10.1016/S0014-2999(96)00877-1[Crossref]
  • [10] D. Getova and N.G. Bowery: “The modulatory effects of high affinity GABAB receptor antagonists in an active avoidance learning paradigm in rats”, Psychopharmacology (Berlin), Vol. 137, (1998), pp. 369–373. http://dx.doi.org/10.1007/s002130050632[Crossref]
  • [11] Y. Nakagawa and T. Takashima: “The GABA (B)receptor antagonist CGP 36742 attenuates the baclofen-and scopolamine-induced deficit in Morris water maze task in rats”, Brain Res., Vol. 766, (1970), pp. 101–106. http://dx.doi.org/10.1016/S0006-8993(97)00529-5[Crossref]
  • [12] C. Mondadori, H.J. Moebius and M. Zingg: “CGP 36742, an orally active GABA B receptor antagonist facilitates memory in a social recognition test in rats”, Behav. Brain Res., Vol. 77, (1996), pp. 227–229. http://dx.doi.org/10.1016/0166-4328(95)00226-X
  • [13] C. Mondadori, H.J. Mobius and J. Borkowski: “The GABA B receptor antagonist CGP 36742 and the nootropic oxiracetam facilitate the formation of long-term memory”, Behav. Brian Res., Vol.77, (1996), pp. 323–325.
  • [14] C.A. Boast and D.C. McIntyre: “Bilateral kindled amygdala foci and inhibitory avoidance behavior in rats: A functional lesion effect”, Physiol. Behav., Vol.8, (1977), pp. 25–28. http://dx.doi.org/10.1016/0031-9384(77)90088-9[Crossref]
  • [15] M. Viana, C. Tomaz and F. Graeff: “The elevated T-maze:a new animal model of anxiety and memory”, Pharmacol. Biochem. Be., Vol. 49, (1994), pp. 549–554. http://dx.doi.org/10.1016/0091-3057(94)90067-1[Crossref]
  • [16] J. Bures and O. Buresova: “Learning and memory”, In: J. Bures, O. Buresova, J. Huston (Eds), Techniques and basic experiments for the study of brain and behavior Elsevier Science Publishers B.V., New York, 1983, pp. 135–208.
  • [17] C. Mondadori, G. Preiswerk and J. Jaekel: “Treatment with a GABAB receptor blocker improves the cognitive performance of mice, rats and rhesus monkeys”, Pharmacol. Comm., Vol. 2, (1992), pp. 93–97.
  • [18] S.E. Cruz-Morales, G.L. Quirarte, M.A. Diaz del Guante and R.A. Prado-Alcala: “Effects of GABA antagonists on inhibitory avoidance”, Life Sci., Vol. 53, (1993), pp. 1325–1330. http://dx.doi.org/10.1016/0024-3205(93)90578-Q[Crossref]
  • [19] A. Gruart, M.D. Munoz and J.M. Delgado-Garcia: “Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice”, J. Neurosci. Vol. 26, (2006), pp. 1077–1087. http://dx.doi.org/10.1523/JNEUROSCI.2834-05.2006[Crossref]
  • [20] S. Zola-Morgan, L. Squire, P. Alvarez-Royo and R. Clower: “Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdale”, Hippocampus, Vol. 1, (1991), pp. 207–220. http://dx.doi.org/10.1002/hipo.450010208[Crossref]
  • [21] M.J. Zaleski, J.R. Nunes Filho, T. Lemos and G.S. Morato: “GABA-B receptors play a role in the development of tolerance to ethanol in mice”, Psychopharmacology (Berl), Vol. 153, (2001), pp. 415–424. http://dx.doi.org/10.1007/s002130000581[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.