Autoimmune hepatitis after high-dose intravenous methylprednisolone pulse in RR-MS

• Authors: Reinhard Reuß , Kerstin Retzlaff , Sabine Vogel , Folker Franke , Patrick Oschmann
• Languages of publication: EN

Abstracts

EN

Three weeks after the administration of intravenous methylprednisolone therapy, a 42-year-old female patient suffering from relapsing-remitting multiple sclerosis (RR-MS) presented with a profound elevation of liver transaminases (GOT 485 U/l, GPT 1082 U/l, glutamyl transpeptidase 170 U/l). Liver biopsy revealed a profound, still active hepatitis with portal lymphocytic infiltration and fibrosis. Most likely, existing acute hepatitis was of autoimmune origin and emerged from an immune rebound phenomenon after immunosuppressive therapy.

Keywords

EN

Hepatitis; multiple sclerosis; methylprednisolone; transaminases; immunosuppression; rebound phenomenon

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2007
• Volume: 2
• Issue: 3
• Pages: 356-359

Dates

published

1 - 9 - 2007

online

3 - 5 - 2007

Contributors

author

Reinhard Reuß

• Department of Neurology, Justus-Liebig-University Gießen, 35392, Gießen, Germany

author

Kerstin Retzlaff

• Department of Neurology, Justus-Liebig-University Gießen, 35392, Gießen, Germany

author

Sabine Vogel

• Department of Neurology, Justus-Liebig-University Gießen, 35392, Gießen, Germany

author

Folker Franke

• Institute of Pathology, Justus-Liebig-University Gießen, 35392, Gießen, Germany

author

Patrick Oschmann

• Department of Neurology, Justus-Liebig-University Gießen, 35392, Gießen, Germany

References

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Identifiers

DOI

10.2478/s11536-007-0025-3