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Journal

2007 | 2 | 1 | 103-107

Article title

Paradoxical effect of sodium valproate that aggravates epilepsy of MELAS in a patient with A3243G mutation of the mitochondrial DNA

Content

Title variants

Languages of publication

EN

Abstracts

EN
Epilepsy is an associated feature of patients with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). A substitution at nucleotide position 3243 A>G of the mitochondrial DNA is the most common mutation encountered both in Caucasians and in Chinese/Taiwanese. We herein report a 38-year-old man with A3243G mutation of the mitochondrial DNA whom developed MELAS. The manifestation of his focal motor epilepsy was aggravated by use of sodium valproate (VPA). The mechanism of this paradoxical effect is proposed.

Publisher

Journal

Year

Volume

2

Issue

1

Pages

103-107

Physical description

Dates

published
1 - 3 - 2007
online
1 - 3 - 2007

Contributors

author
  • Departments of Neurology and Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan, ROC
author
  • Departments of Neurology and Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan, ROC

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-007-0007-5
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