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Journal
2007 | 2 | 1 | 103-107
Article title

Paradoxical effect of sodium valproate that aggravates epilepsy of MELAS in a patient with A3243G mutation of the mitochondrial DNA

Content
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Languages of publication
EN
Abstracts
EN
Epilepsy is an associated feature of patients with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). A substitution at nucleotide position 3243 A>G of the mitochondrial DNA is the most common mutation encountered both in Caucasians and in Chinese/Taiwanese. We herein report a 38-year-old man with A3243G mutation of the mitochondrial DNA whom developed MELAS. The manifestation of his focal motor epilepsy was aggravated by use of sodium valproate (VPA). The mechanism of this paradoxical effect is proposed.
Publisher

Journal
Year
Volume
2
Issue
1
Pages
103-107
Physical description
Dates
published
1 - 3 - 2007
online
1 - 3 - 2007
Contributors
author
  • Departments of Neurology and Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan, ROC
author
  • Departments of Neurology and Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan, ROC
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-007-0007-5
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